WEKO3
-
RootNode
アイテム
Two mechanistically distinct effects of dihydropyridine nifedipine on Ca(V)1.2 L-type Ca2+ channels revealed by Timothy syndrome mutation
http://hdl.handle.net/10091/16908
http://hdl.handle.net/10091/16908662a5827-9f5c-4ad0-a71f-3a737a81ca7f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Two_mechanistically_distinct_effects_dihydropyridine_nifedipine.pdf (802.9 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2013-04-01 | |||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||
| タイトル | Two mechanistically distinct effects of dihydropyridine nifedipine on Ca(V)1.2 L-type Ca2+ channels revealed by Timothy syndrome mutation | |||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.ejphar.2012.04.029 | |||||||||||||||||||||||||
| 関連名称 | 10.1016/j.ejphar.2012.04.029 | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | Ca(V)1.2 L-type Ca2+ channel, Voltage-dependent inactivation, Dihydropyridine, Nifedipine, Timothy syndrome, Allosteric model | |||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||||||||
| 著者 |
Sheng, Xiaona
× Sheng, Xiaona
× Nakada, Tsutomu
× Kobayashi, Motohiro
× Kashihara, Toshihide
× Shibazaki, Toshihide
× Horiuchi-Hirose, Miwa
× Gomi, Simmon
× Hirose, Masamichi
× Aoyama, Toshifumi
× Yamada, Mitsuhiko
|
|||||||||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||||
| 氏名 | Nakada, Tsutomu | |||||||||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OVkhuNkh.html | |||||||||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||||
| 氏名 | Yamada, Mitsuhiko | |||||||||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jhSCupca.html | |||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||
| 出版者 | ELSEVIER SCIENCE BV | |||||||||||||||||||||||||
| 引用 | ||||||||||||||||||||||||||
| 内容記述 | EUROPEAN JOURNAL OF PHARMACOLOGY. 685(1-3):15-23 (2012) | |||||||||||||||||||||||||
| 書誌情報 |
EUROPEAN JOURNAL OF PHARMACOLOGY 巻 685, 号 1-2, p. 15-23, 発行日 2012-06-15 |
|||||||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||||||
| 内容記述 | Dihydropyridine Ca2+ channel antagonists (DHPs) block Ca(V)1.2 L-type Ca2+ channels (LTCCs) by stabilizing their voltage-dependent inactivation (VDI); however, it is still not clear how DHPs allosterically interact with the kinetically distinct (fast and slow) VDI. Thus, we analyzed the effect of a prototypical DHP, nifedipine on LTCCs with or without the Timothy syndrome mutation that resides in the I-II linker (LI-II) of Ca(V)1.2 subunits and impairs VDI. Whole-cell Ba2+ currents mediated by rabbit Ca(V)1.2 with or without the Timothy mutation (G436R) (analogous to the human G406R mutation) were analyzed in the presence and absence of nifedipine. In the absence of nifedipine, the mutation significantly impaired fast closed-and open-state VDI (CSI and OSI) at -40 and 0 mV, respectively, but did not affect channels' kinetics at -100 mV. Nifedipine equipotently blocked these channels at -80 mV. In wild-type LTCCs, nifedipine promoted fast CSI and OSI at -40 and 0 mV and promoted or stabilized slow CSI at -40 and -100 mV, respectively. In LTCCs with the mutation, nifedipine resumed the impaired fast CSI and OSI at -40 and 0 mV, respectively, and had the same effect on slow CSI as in wild-type LTCCs. Therefore, nifedipine has two mechanistically distinct effects on LTCCs: the promotion of fast CSI/OSI caused by LI-II at potentials positive to the sub-threshold potential and the promotion or stabilization of slow CSI caused by different mechanisms at potentials negative to the subthreshold potential. | |||||||||||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||||||||||
| ISSN | ||||||||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||||||||
| 収録物識別子 | 0014-2999 | |||||||||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||||||
| 収録物識別子 | AA00639687 | |||||||||||||||||||||||||
| PubMed | ||||||||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/22554770 | |||||||||||||||||||||||||
| 関連名称 | 22554770 | |||||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||||
| 権利情報 | Copyright© 2012 Elsevier B.V. | |||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||||
| WoS | ||||||||||||||||||||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000304205600003 | |||||||||||||||||||||||||
Share
Cite as
Sheng, Xiaona, Nakada, Tsutomu, Kobayashi, Motohiro, Kashihara, Toshihide, Shibazaki, Toshihide, Horiuchi-Hirose, Miwa, Gomi, Simmon, Hirose, Masamichi, Aoyama, Toshifumi, Yamada, Mitsuhiko, 2012, Two mechanistically distinct effects of dihydropyridine nifedipine on Ca(V)1.2 L-type Ca2+ channels revealed by Timothy syndrome mutation: ELSEVIER SCIENCE BV, 15–23 p.
Loading...
