| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-04-01 |
| タイトル |
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タイトル |
Selective alpha(1A)-Adrenoceptor Stimulation Induces Mueller's Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation |
| 言語 |
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言語 |
eng |
| DOI |
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関連識別子 |
https://doi.org/10.3109/02713680903518858 |
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関連名称 |
10.3109/02713680903518858 |
| キーワード |
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主題 |
alpha(1)-Adrenoceptors, Blepharoptosis, Canine, Eyelid, Mueller's smooth muscle |
| 資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Yano, Shiharu
Hirose, Masamichi
Nakada, Tsutomu
Nakayama, Jun
Matsuo, Kiyoshi
Yamada, Mitsuhiko
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| 信州大学研究者総覧へのリンク |
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氏名 |
Nakada, Tsutomu |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.OVkhuNkh.html |
| 信州大学研究者総覧へのリンク |
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氏名 |
Nakayama, Jun |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.HCApHFkh.html |
| 信州大学研究者総覧へのリンク |
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氏名 |
Yamada, Mitsuhiko |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jhSCupca.html |
| 出版者 |
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出版者 |
INFORMA HEALTHCARE |
| 引用 |
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内容記述 |
CURRENT EYE RESEARCH. 35(5):363-369 (2010) |
| 書誌情報 |
CURRENT EYE RESEARCH
巻 35,
号 5,
p. 363-369,
発行日 2010-05
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| 抄録 |
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内容記述 |
Purpose: It has been demonstrated that in patients with aponeurotic blepharoptosis, alpha(1)-adrenoceptor stimulation causes the contraction of the upper eyelid tarsal smooth muscle (Mueller's muscle) and opening of the eye. However, alpha(1)-adrenoceptor subtypes mediating the contraction of Mueller's muscle are still unclear. This study was designed to identify the alpha(1)-adrenoceptor subtypes in Mueller's muscle. Materials and Methods: A newly developed canine upper eyelid preparation was retrogradely perfused with a drug-containing Krebs-Henseleit solution through the angular vein in a temperature-controlled organ chamber. The contraction of the preparation was measured with a force-displacement transducer. Results: Phenylephrine, an alpha(1)-adrenoceptor agonist, increased the upper eyelid contractile force in a dose-dependent manner (K(0.5) = 110 nmol). Interestingly, the contraction in response to phenylephrine was persistent and hardly recovered to a base line level for more than 100 min after washout of the drug. WB4101 (100 nM), an alpha(1A)- and alpha(1D)-adrenoceptor antagonist, but not BMY7378 (100 nM), a selective alpha(1D)-adrenoceptor antagonist, competitively inhibited the phenylephrine-induced contraction. ABT-866, a selective alpha(1A)-adrenoceptor agonist, increased the upper eyelid contractile force as effectively as phenylephrine in a dose-dependent manner (K(0.5) = 190 nmol), and the contraction continued again for more than 100 min. Conclusion: These results suggest that selective alpha(1A)-adrenoceptor agonists, such as ABT-866, induce the sustained Mueller's muscle contraction and may be useful in pharmacological treatment of blepharoptosis. |
| 資源タイプ（コンテンツの種類） |
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0271-3683 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10621338 |
| PubMed |
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識別子タイプ |
PMID |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/20450248 |
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関連名称 |
20450248 |
| 権利 |
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権利情報 |
Copyright© 2010 Informa Healthcare USA, Inc. |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000282893900001 |
Selective_a1A-Adrenoceptor_Stimulation_Induces_Mueller’s_Smooth_Muscle_Contraction.pdf (379.6 kB)
