{"_buckets": {"deposit": "6a9f6d81-499a-43ba-b269-d455848edf7c"}, "_deposit": {"id": "3791", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3791"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003791"}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "369", "bibliographicPageStart": "363", "bibliographicVolumeNumber": "35", "bibliographic_titles": [{"bibliographic_title": "CURRENT EYE RESEARCH"}]}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Purpose: It has been demonstrated that in patients with aponeurotic blepharoptosis, alpha(1)-adrenoceptor stimulation causes the contraction of the upper eyelid tarsal smooth muscle (Mueller\u0027s muscle) and opening of the eye. However, alpha(1)-adrenoceptor subtypes mediating the contraction of Mueller\u0027s muscle are still unclear. This study was designed to identify the alpha(1)-adrenoceptor subtypes in Mueller\u0027s muscle. Materials and Methods: A newly developed canine upper eyelid preparation was retrogradely perfused with a drug-containing Krebs-Henseleit solution through the angular vein in a temperature-controlled organ chamber. The contraction of the preparation was measured with a force-displacement transducer. Results: Phenylephrine, an alpha(1)-adrenoceptor agonist, increased the upper eyelid contractile force in a dose-dependent manner (K(0.5) = 110 nmol). Interestingly, the contraction in response to phenylephrine was persistent and hardly recovered to a base line level for more than 100 min after washout of the drug. WB4101 (100 nM), an alpha(1A)- and alpha(1D)-adrenoceptor antagonist, but not BMY7378 (100 nM), a selective alpha(1D)-adrenoceptor antagonist, competitively inhibited the phenylephrine-induced contraction. ABT-866, a selective alpha(1A)-adrenoceptor agonist, increased the upper eyelid contractile force as effectively as phenylephrine in a dose-dependent manner (K(0.5) = 190 nmol), and the contraction continued again for more than 100 min. Conclusion: These results suggest that selective alpha(1A)-adrenoceptor agonists, such as ABT-866, induce the sustained Mueller\u0027s muscle contraction and may be useful in pharmacological treatment of blepharoptosis.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "CURRENT EYE RESEARCH. 35(5):363-369 (2010)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Nakada, Tsutomu", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.OVkhuNkh.html"}, {"subitem_link_text": "Nakayama, Jun", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.HCApHFkh.html"}, {"subitem_link_text": "Yamada, Mitsuhiko", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.jhSCupca.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000282893900001"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "INFORMA HEALTHCARE"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "20450248"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=20450248", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.3109/02713680903518858"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.3109/02713680903518858", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "Copyright\u00a9 2010 Informa Healthcare USA, Inc."}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0271-3683", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0271-3683", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10621338", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "alpha(1)-Adrenoceptors; Blepharoptosis; Canine; Eyelid; Mueller\u0027s smooth muscle"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "APONEUROTIC BLEPHAROPTOSIS; LEVATOR MUSCLE; RABBIT IRIS; SUBTYPES; ALPHA(1)-ADRENOCEPTORS; INNERVATION; ANTAGONIST; MOVEMENTS; ALPHA(1); ABT-866"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Purpose: It has been demonstrated that in patients with aponeurotic blepharoptosis, alpha(1)-adrenoceptor stimulation causes the contraction of the upper eyelid tarsal smooth muscle (Mueller\u0027s muscle) and opening of the eye. However, alpha(1)-adrenoceptor subtypes mediating the contraction of Mueller\u0027s muscle are still unclear. This study was designed to identify the alpha(1)-adrenoceptor subtypes in Mueller\u0027s muscle. Materials and Methods: A newly developed canine upper eyelid preparation was retrogradely perfused with a drug-containing Krebs-Henseleit solution through the angular vein in a temperature-controlled organ chamber. The contraction of the preparation was measured with a force-displacement transducer. Results: Phenylephrine, an alpha(1)-adrenoceptor agonist, increased the upper eyelid contractile force in a dose-dependent manner (K(0.5) = 110 nmol). Interestingly, the contraction in response to phenylephrine was persistent and hardly recovered to a base line level for more than 100 min after washout of the drug. WB4101 (100 nM), an alpha(1A)- and alpha(1D)-adrenoceptor antagonist, but not BMY7378 (100 nM), a selective alpha(1D)-adrenoceptor antagonist, competitively inhibited the phenylephrine-induced contraction. ABT-866, a selective alpha(1A)-adrenoceptor agonist, increased the upper eyelid contractile force as effectively as phenylephrine in a dose-dependent manner (K(0.5) = 190 nmol), and the contraction continued again for more than 100 min. Conclusion: These results suggest that selective alpha(1A)-adrenoceptor agonists, such as ABT-866, induce the sustained Mueller\u0027s muscle contraction and may be useful in pharmacological treatment of blepharoptosis."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yano,  Shiharu"}], "nameIdentifiers": [{"nameIdentifier": "7071", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirose,  Masamichi"}], "nameIdentifiers": [{"nameIdentifier": "7072", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakada,  Tsutomu"}], "nameIdentifiers": [{"nameIdentifier": "7073", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakayama,  Jun"}], "nameIdentifiers": [{"nameIdentifier": "7074", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuo,  Kiyoshi"}], "nameIdentifiers": [{"nameIdentifier": "7075", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamada,  Mitsuhiko"}], "nameIdentifiers": [{"nameIdentifier": "7076", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "filename": "Selective_a1A-Adrenoceptor_Stimulation_Induces_Mueller\u2019s_Smooth_Muscle_Contraction.pdf", "filesize": [{"value": "379.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3796000, "url": {"label": "Selective_a1A-Adrenoceptor_Stimulation_Induces_Mueller\u2019s_Smooth_Muscle_Contraction.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3791/files/Selective_a1A-Adrenoceptor_Stimulation_Induces_Mueller\u2019s_Smooth_Muscle_Contraction.pdf"}, "version_id": "c7525993-0d7e-438d-a295-85d90bc210f9"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "alpha(1)-Adrenoceptors", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Blepharoptosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Canine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Eyelid", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Mueller\u0027s smooth muscle", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Selective alpha(1A)-Adrenoceptor Stimulation Induces Mueller\u0027s Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Selective alpha(1A)-Adrenoceptor Stimulation Induces Mueller\u0027s Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/16900", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2013-04-01"}, "publish_date": "2013-04-01", "publish_status": "0", "recid": "3791", "relation": {}, "relation_version_is_last": true, "title": ["Selective alpha(1A)-Adrenoceptor Stimulation Induces Mueller\u0027s Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation"], "weko_shared_id": null}