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However, alpha(1)-adrenoceptor subtypes mediating the contraction of Mueller\u0027s muscle are still unclear. This study was designed to identify the alpha(1)-adrenoceptor subtypes in Mueller\u0027s muscle. Materials and Methods: A newly developed canine upper eyelid preparation was retrogradely perfused with a drug-containing Krebs-Henseleit solution through the angular vein in a temperature-controlled organ chamber. The contraction of the preparation was measured with a force-displacement transducer. Results: Phenylephrine, an alpha(1)-adrenoceptor agonist, increased the upper eyelid contractile force in a dose-dependent manner (K(0.5) = 110 nmol). Interestingly, the contraction in response to phenylephrine was persistent and hardly recovered to a base line level for more than 100 min after washout of the drug. 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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Selective alpha(1A)-Adrenoceptor Stimulation Induces Mueller's Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation

http://hdl.handle.net/10091/16900
2e2692a1-347b-47c3-aab6-fccf5a411e25
名前 / ファイル ライセンス アクション
Selective_a1A-Adrenoceptor_Stimulation_Induces_Mueller’s_Smooth_Muscle_Contraction.pdf Selective_a1A-Adrenoceptor_Stimulation_Induces_Mueller’s_Smooth_Muscle_Contraction.pdf (379.6 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-04-01
タイトル
言語 en
タイトル Selective alpha(1A)-Adrenoceptor Stimulation Induces Mueller's Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation
言語
言語 eng
キーワード
主題Scheme Other
主題 alpha(1)-Adrenoceptors
キーワード
主題Scheme Other
主題 Blepharoptosis
キーワード
主題Scheme Other
主題 Canine
キーワード
主題Scheme Other
主題 Eyelid
キーワード
主題Scheme Other
主題 Mueller's smooth muscle
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Yano, Shiharu

× Yano, Shiharu

WEKO 7071

en Yano, Shiharu

Search repository
Hirose, Masamichi

× Hirose, Masamichi

WEKO 7072

en Hirose, Masamichi

Search repository
Nakada, Tsutomu

× Nakada, Tsutomu

WEKO 7073

en Nakada, Tsutomu

Search repository
Nakayama, Jun

× Nakayama, Jun

WEKO 7074

en Nakayama, Jun

Search repository
Matsuo, Kiyoshi

× Matsuo, Kiyoshi

WEKO 7075

en Matsuo, Kiyoshi

Search repository
Yamada, Mitsuhiko

× Yamada, Mitsuhiko

WEKO 7076

en Yamada, Mitsuhiko

Search repository
信州大学研究者総覧へのリンク
氏名 Nakada, Tsutomu
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OVkhuNkh.html
信州大学研究者総覧へのリンク
氏名 Nakayama, Jun
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HCApHFkh.html
信州大学研究者総覧へのリンク
氏名 Yamada, Mitsuhiko
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jhSCupca.html
出版者
出版者 INFORMA HEALTHCARE
引用
内容記述タイプ Other
内容記述 CURRENT EYE RESEARCH. 35(5):363-369 (2010)
書誌情報 CURRENT EYE RESEARCH

巻 35, 号 5, p. 363-369, 発行日 2010-05
抄録
内容記述タイプ Abstract
内容記述 Purpose: It has been demonstrated that in patients with aponeurotic blepharoptosis, alpha(1)-adrenoceptor stimulation causes the contraction of the upper eyelid tarsal smooth muscle (Mueller's muscle) and opening of the eye. However, alpha(1)-adrenoceptor subtypes mediating the contraction of Mueller's muscle are still unclear. This study was designed to identify the alpha(1)-adrenoceptor subtypes in Mueller's muscle. Materials and Methods: A newly developed canine upper eyelid preparation was retrogradely perfused with a drug-containing Krebs-Henseleit solution through the angular vein in a temperature-controlled organ chamber. The contraction of the preparation was measured with a force-displacement transducer. Results: Phenylephrine, an alpha(1)-adrenoceptor agonist, increased the upper eyelid contractile force in a dose-dependent manner (K(0.5) = 110 nmol). Interestingly, the contraction in response to phenylephrine was persistent and hardly recovered to a base line level for more than 100 min after washout of the drug. WB4101 (100 nM), an alpha(1A)- and alpha(1D)-adrenoceptor antagonist, but not BMY7378 (100 nM), a selective alpha(1D)-adrenoceptor antagonist, competitively inhibited the phenylephrine-induced contraction. ABT-866, a selective alpha(1A)-adrenoceptor agonist, increased the upper eyelid contractile force as effectively as phenylephrine in a dose-dependent manner (K(0.5) = 190 nmol), and the contraction continued again for more than 100 min. Conclusion: These results suggest that selective alpha(1A)-adrenoceptor agonists, such as ABT-866, induce the sustained Mueller's muscle contraction and may be useful in pharmacological treatment of blepharoptosis.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0271-3683
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10621338
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/20450248
関連名称
関連名称 20450248
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.3109/02713680903518858
関連名称
関連名称 10.3109/02713680903518858
権利
権利情報 Copyright© 2010 Informa Healthcare USA, Inc.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000282893900001
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