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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Hrs Recognizes a Hydrophobic Amino Acid Cluster in Cytokine Receptors during Ubiquitin-independent Endosomal Sorting

http://hdl.handle.net/10091/16885
http://hdl.handle.net/10091/16885
092d6d92-0216-4f7d-94d8-c69069c4c7f3
名前 / ファイル ライセンス アクション
HRS_RECOGNIZES_HYDROPHOBIC_AMINO_ACID_CLUSTER.pdf HRS_RECOGNIZES_HYDROPHOBIC_AMINO_ACID_CLUSTER.pdf (4.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-04-01
タイトル
タイトル Hrs Recognizes a Hydrophobic Amino Acid Cluster in Cytokine Receptors during Ubiquitin-independent Endosomal Sorting
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1074/jbc.M110.191924
関連名称 10.1074/jbc.M110.191924
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Amano, Yuji

× Amano, Yuji

en Amano, Yuji

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Yamashita, Yuki

× Yamashita, Yuki

en Yamashita, Yuki

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Kojima, Katsuhiko

× Kojima, Katsuhiko

en Kojima, Katsuhiko

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Yoshino, Kazuhisa

× Yoshino, Kazuhisa

en Yoshino, Kazuhisa

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Tanaka, Nobuyuki

× Tanaka, Nobuyuki

en Tanaka, Nobuyuki

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Sugamura, Kazuo

× Sugamura, Kazuo

en Sugamura, Kazuo

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Takeshita, Toshikazu

× Takeshita, Toshikazu

en Takeshita, Toshikazu

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信州大学研究者総覧へのリンク
氏名 Amano, Yuji
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jUnFumkh.html
信州大学研究者総覧へのリンク
氏名 Kojima, Katsuhiko
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OCcFuakh.html
信州大学研究者総覧へのリンク
氏名 Yoshino, Kazuhisa
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WhfFuNkh.html
信州大学研究者総覧へのリンク
氏名 Takeshita, Toshikazu
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.uVLaOmSF.html
出版者
出版者 AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
引用
内容記述 JOURNAL OF BIOLOGICAL CHEMISTRY. 286(17):15458-15472 (2011)
書誌情報 JOURNAL OF BIOLOGICAL CHEMISTRY

巻 286, 号 17, p. 15458-15472, 発行日 2011-04-29
抄録
内容記述 Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is a component of the ESCRT-0 protein complex that captures ubiquitylated cargo proteins and sorts them to the lysosomal pathway. Although Hrs acts as a key transporter for ubiquitin-dependent endosomal sorting, we previously reported that Hrs is also involved in ubiquitin-independent endosomal sorting of interleukin-2 receptor beta (IL-2R beta). Here, we show direct interactions between bacterially expressed Hrs and interleukin-4 receptor alpha (IL-4R alpha), indicating that their binding is not required for ubiquitylation of the receptors, similar to the case for IL-2R beta. Examinations of the Hrs binding regions of the receptors reveal that a hydrophobic amino acid cluster in both IL-2R beta and IL-4R alpha is essential for the binding. Whereas the wild-type receptors are delivered to LAMP1-positive late endosomes, mutant receptors lacking the hydrophobic amino acid cluster are sorted to lysobisphosphatidic acid-positive late endosomes rather than LAMP1-positive late endosomes. We also show that the degradation of these mutant receptors is attenuated. Accordingly, Hrs functions during ubiquitin-independent endosomal sorting of the receptors by recognizing the hydrophobic amino acid cluster. These findings suggest the existence of a group of cargo proteins that have this hydrophobic amino acid cluster as a ubiquitin-independent sorting signal.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 0021-9258
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00251083
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/21362618
関連名称 21362618
権利
権利情報 This research was originally published in The Journal of Biological Chemistry. Amano Y, et al. Hrs Recognizes a Hydrophobic Amino Acid Cluster in Cytokine Receptors during Ubiquitin-independent Endosomal Sorting. The Journal of Biological Chemistry. 2011; 286:15458-15472. © the American Society for Biochemistry and Molecular Biology.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000289788300074
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