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Hrs Recognizes a Hydrophobic Amino Acid Cluster in Cytokine Receptors during Ubiquitin-independent Endosomal Sorting
http://hdl.handle.net/10091/16885
http://hdl.handle.net/10091/16885092d6d92-0216-4f7d-94d8-c69069c4c7f3
| 名前 / ファイル | ライセンス | アクション |
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HRS_RECOGNIZES_HYDROPHOBIC_AMINO_ACID_CLUSTER.pdf (4.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2013-04-01 | |||||||||||||||||||
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| タイトル | Hrs Recognizes a Hydrophobic Amino Acid Cluster in Cytokine Receptors during Ubiquitin-independent Endosomal Sorting | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| DOI | ||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1074/jbc.M110.191924 | |||||||||||||||||||
| 関連名称 | 10.1074/jbc.M110.191924 | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||
| 著者 |
Amano, Yuji
× Amano, Yuji
× Yamashita, Yuki
× Kojima, Katsuhiko
× Yoshino, Kazuhisa
× Tanaka, Nobuyuki
× Sugamura, Kazuo
× Takeshita, Toshikazu
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||||
| 氏名 | Amano, Yuji | |||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jUnFumkh.html | |||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||
| 氏名 | Kojima, Katsuhiko | |||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OCcFuakh.html | |||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||
| 氏名 | Yoshino, Kazuhisa | |||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WhfFuNkh.html | |||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||
| 氏名 | Takeshita, Toshikazu | |||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.uVLaOmSF.html | |||||||||||||||||||
| 出版者 | ||||||||||||||||||||
| 出版者 | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | |||||||||||||||||||
| 引用 | ||||||||||||||||||||
| 内容記述 | JOURNAL OF BIOLOGICAL CHEMISTRY. 286(17):15458-15472 (2011) | |||||||||||||||||||
| 書誌情報 |
JOURNAL OF BIOLOGICAL CHEMISTRY 巻 286, 号 17, p. 15458-15472, 発行日 2011-04-29 |
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| 抄録 | ||||||||||||||||||||
| 内容記述 | Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is a component of the ESCRT-0 protein complex that captures ubiquitylated cargo proteins and sorts them to the lysosomal pathway. Although Hrs acts as a key transporter for ubiquitin-dependent endosomal sorting, we previously reported that Hrs is also involved in ubiquitin-independent endosomal sorting of interleukin-2 receptor beta (IL-2R beta). Here, we show direct interactions between bacterially expressed Hrs and interleukin-4 receptor alpha (IL-4R alpha), indicating that their binding is not required for ubiquitylation of the receptors, similar to the case for IL-2R beta. Examinations of the Hrs binding regions of the receptors reveal that a hydrophobic amino acid cluster in both IL-2R beta and IL-4R alpha is essential for the binding. Whereas the wild-type receptors are delivered to LAMP1-positive late endosomes, mutant receptors lacking the hydrophobic amino acid cluster are sorted to lysobisphosphatidic acid-positive late endosomes rather than LAMP1-positive late endosomes. We also show that the degradation of these mutant receptors is attenuated. Accordingly, Hrs functions during ubiquitin-independent endosomal sorting of the receptors by recognizing the hydrophobic amino acid cluster. These findings suggest the existence of a group of cargo proteins that have this hydrophobic amino acid cluster as a ubiquitin-independent sorting signal. | |||||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||||
| ISSN | ||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||
| 収録物識別子 | 0021-9258 | |||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA00251083 | |||||||||||||||||||
| PubMed | ||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/21362618 | |||||||||||||||||||
| 関連名称 | 21362618 | |||||||||||||||||||
| 権利 | ||||||||||||||||||||
| 権利情報 | This research was originally published in The Journal of Biological Chemistry. Amano Y, et al. Hrs Recognizes a Hydrophobic Amino Acid Cluster in Cytokine Receptors during Ubiquitin-independent Endosomal Sorting. The Journal of Biological Chemistry. 2011; 286:15458-15472. © the American Society for Biochemistry and Molecular Biology. | |||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||
| WoS | ||||||||||||||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000289788300074 | |||||||||||||||||||
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Cite as
Amano, Yuji, Yamashita, Yuki, Kojima, Katsuhiko, Yoshino, Kazuhisa, Tanaka, Nobuyuki, Sugamura, Kazuo, Takeshita, Toshikazu, 2011, Hrs Recognizes a Hydrophobic Amino Acid Cluster in Cytokine Receptors during Ubiquitin-independent Endosomal Sorting: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 15458–15472 p.
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