Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2013-03-18 |
タイトル |
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タイトル |
Role of satellite cell-derived l-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.neuroscience.2010.11.046 |
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関連名称 |
10.1016/j.neuroscience.2010.11.046 |
キーワード |
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主題 |
L-serine, dorsal root ganglion, paclitaxel, peripheral neuropathy, 3-phosphoglycerate dehydrogenase |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Kiya, T
Kawamata, T
Namiki, A
Yamakage, M
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信州大学研究者総覧へのリンク |
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氏名 |
Kawamata, T |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.yaTUuNkh.html |
出版者 |
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出版者 |
PERGAMON-ELSEVIER SCIENCE LTD |
引用 |
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内容記述 |
NEUROSCIENCE. 174(0):190-199 (2011) |
書誌情報 |
NEUROSCIENCE
巻 174,
p. 190-199,
発行日 2011-02-03
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抄録 |
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内容記述 |
Paclitaxel is one of the most commonly used antineoplastic drugs for the treatment of solid tumors. Unfortunately, its use is often associated with dose-limiting painful peripheral neuropathy and subsequent neuropathic pain that is resistant to standard analgesics. However, there are few clinically available drugs or drug classes for the treatment of paclitaxel-induced neuropathy due to a lack of information regarding the mechanisms responsible for it. In this study, we examined the involvement of L-serine in paclitaxel-induced hyperalgesia/allodynia and decrease in sensory nerve conduction velocity (SNCV). We used a preclinical rat model of paclitaxel-induced painful peripheral neuropathy. Response to von Frey filaments, SNCV, 3-phosphoglycerate dehydrogenase (3PGDH) expression, and L-serine concentration were examined. Effects of L-serine administration were also investigated. Paclitaxel treatment induced mechanical allodynia/hyperalgesia and reduction of SNCV. Paclitaxel also decreased the L-serine concentration in the dorsal root ganglion (DRG) but not in the sciatic nerve or spinal cord. In addition, paclitaxel decreased expression of 3PGDH, a biosynthetic enzyme of L-serine, in the DRG. Immunohistochemistry showed that 3PGDH was localized in satellite cells but not in neurons in the DRG. Intraperitoneal administration of L-serine improved both paclitaxel-induced mechanical allodynia/hyperalgesia and the reduction of SNCV. These results suggest that satellite cell-derived L-serine in the DRG plays an important role in paclitaxel-induced painful peripheral neuropathy. These findings may lead to novel strategies for the treatment of paclitaxel-induced painful peripheral neuropathy. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0306-4522 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA0075489X |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/21118710 |
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関連名称 |
21118710 |
権利 |
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権利情報 |
Copyright© 2011 IBRO. Published by Elsevier Ltd. |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000286558000018 |