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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Role of satellite cell-derived l-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy

http://hdl.handle.net/10091/16811
7afcf701-dd36-4262-91a6-f14633f23dae
名前 / ファイル ライセンス アクション
Role_of_satellite_cell-derived_l-serine.pdf Role_of_satellite_cell-derived_l-serine.pdf (1.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-03-18
タイトル
言語 en
タイトル Role of satellite cell-derived l-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy
言語
言語 eng
キーワード
主題Scheme Other
主題 L-serine
キーワード
主題Scheme Other
主題 dorsal root ganglion
キーワード
主題Scheme Other
主題 paclitaxel
キーワード
主題Scheme Other
主題 peripheral neuropathy
キーワード
主題Scheme Other
主題 3-phosphoglycerate dehydrogenase
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Kiya, T

× Kiya, T

WEKO 7158

en Kiya, T

Search repository
Kawamata, T

× Kawamata, T

WEKO 7159

en Kawamata, T

Search repository
Namiki, A

× Namiki, A

WEKO 7160

en Namiki, A

Search repository
Yamakage, M

× Yamakage, M

WEKO 7161

en Yamakage, M

Search repository
信州大学研究者総覧へのリンク
氏名 Kawamata, T
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.yaTUuNkh.html
出版者
出版者 PERGAMON-ELSEVIER SCIENCE LTD
引用
内容記述タイプ Other
内容記述 NEUROSCIENCE. 174(0):190-199 (2011)
書誌情報 NEUROSCIENCE

巻 174, p. 190-199, 発行日 2011-02-03
抄録
内容記述タイプ Abstract
内容記述 Paclitaxel is one of the most commonly used antineoplastic drugs for the treatment of solid tumors. Unfortunately, its use is often associated with dose-limiting painful peripheral neuropathy and subsequent neuropathic pain that is resistant to standard analgesics. However, there are few clinically available drugs or drug classes for the treatment of paclitaxel-induced neuropathy due to a lack of information regarding the mechanisms responsible for it. In this study, we examined the involvement of L-serine in paclitaxel-induced hyperalgesia/allodynia and decrease in sensory nerve conduction velocity (SNCV). We used a preclinical rat model of paclitaxel-induced painful peripheral neuropathy. Response to von Frey filaments, SNCV, 3-phosphoglycerate dehydrogenase (3PGDH) expression, and L-serine concentration were examined. Effects of L-serine administration were also investigated. Paclitaxel treatment induced mechanical allodynia/hyperalgesia and reduction of SNCV. Paclitaxel also decreased the L-serine concentration in the dorsal root ganglion (DRG) but not in the sciatic nerve or spinal cord. In addition, paclitaxel decreased expression of 3PGDH, a biosynthetic enzyme of L-serine, in the DRG. Immunohistochemistry showed that 3PGDH was localized in satellite cells but not in neurons in the DRG. Intraperitoneal administration of L-serine improved both paclitaxel-induced mechanical allodynia/hyperalgesia and the reduction of SNCV. These results suggest that satellite cell-derived L-serine in the DRG plays an important role in paclitaxel-induced painful peripheral neuropathy. These findings may lead to novel strategies for the treatment of paclitaxel-induced painful peripheral neuropathy.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0306-4522
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA0075489X
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/21118710
関連名称
関連名称 21118710
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.neuroscience.2010.11.046
関連名称
関連名称 10.1016/j.neuroscience.2010.11.046
権利
権利情報 Copyright© 2011 IBRO. Published by Elsevier Ltd.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000286558000018
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