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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Kidney dysfunction induced by protein overload nephropathy reduces serum sulfatide levels in mice

http://hdl.handle.net/10091/16261
http://hdl.handle.net/10091/16261
347fc063-1124-4f29-b4cc-ad51ae29dea9
名前 / ファイル ライセンス アクション
Kidney_dysfunction_induced_protein_overload_nephropathy_reduces_serum.pdf Kidney_dysfunction_induced_protein_overload_nephropathy_reduces_serum.pdf (646.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-02-13
タイトル
タイトル Kidney dysfunction induced by protein overload nephropathy reduces serum sulfatide levels in mice
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1111/j.1440-1797.2009.01116.x
関連名称 10.1111/j.1440-1797.2009.01116.x
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Li, Gang

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Hu, Rui

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en Hu, Rui

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Kamijo, Yuji

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en Kamijo, Yuji

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Nakajima, Takero

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Aoyama, Toshifumi

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en Aoyama, Toshifumi

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Ehara, Takashi

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Shigematsu, Hidekazu

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Kannagi, Reiji

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Kyogashima, Mamoru

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Hara, Atsushi

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信州大学研究者総覧へのリンク
氏名 Kamijo, Yuji
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.gCTFuakh.html
信州大学研究者総覧へのリンク
氏名 Nakajima, Takero
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ymTNuNkh.html
出版者
出版者 WILEY-BLACKWELL PUBLISHING, INC
引用
内容記述 NEPHROLOGY. 14(7):658-662 (2009)
書誌情報 NEPHROLOGY

巻 14, 号 7, p. 658-662, 発行日 2009-10
抄録
内容記述 We recently proposed serum sulfatides as a novel biomarker for cardiovascular disease in patients with end-stage renal failure (ESRF), based on the possible antithrombotic properties of this molecule. In this earlier study, the level of serum sulfatides was gradually decreased in parallel with kidney dysfunction; however the precise mechanism underlying this decrease was unknown. The aim of the present study was to investigate the mechanism underlying the decrease in serum sulfatide levels caused by kidney dysfunction in an experimental animal model. To produce a kidney dysfunction animal model, we prepared a mouse model of protein overload nephropathy. Using high-throughput analysis combined with matrix-assisted laser desorption ionisation time-of-flight mass spectrometry, we measured the levels of sulfatides in the sera, livers, small intestines and kidneys of protein overload nephropathy mice. As the disease progressed, the levels of sulfatides in sera decreased. Also, the levels in livers and small intestines decreased in a similar manner to those in sera, to approximately 60% of the original levels. On the contrary, those in kidneys increased by approximately 1.4-fold. Our results indicate that kidney dysfunction affects the levels of sulfatides in lipoprotein-producing organs, such as livers and small intestines, and lowers the levels of sulfatides in sera.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 1320-5358
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11055666
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/19796024
関連名称 19796024
権利
権利情報 The definitive version is available at wileyonlinelibrary.com
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000270311700005
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