| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-02-13 |
| タイトル |
|
|
タイトル |
Kidney dysfunction induced by protein overload nephropathy reduces serum sulfatide levels in mice |
| 言語 |
|
|
言語 |
eng |
| DOI |
|
|
|
関連識別子 |
https://doi.org/10.1111/j.1440-1797.2009.01116.x |
|
|
関連名称 |
10.1111/j.1440-1797.2009.01116.x |
| 資源タイプ |
|
|
資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Li, Gang
Hu, Rui
Kamijo, Yuji
Nakajima, Takero
Aoyama, Toshifumi
Ehara, Takashi
Shigematsu, Hidekazu
Kannagi, Reiji
Kyogashima, Mamoru
Hara, Atsushi
|
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Kamijo, Yuji |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.gCTFuakh.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Nakajima, Takero |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ymTNuNkh.html |
| 出版者 |
|
|
出版者 |
WILEY-BLACKWELL PUBLISHING, INC |
| 引用 |
|
|
内容記述 |
NEPHROLOGY. 14(7):658-662 (2009) |
| 書誌情報 |
NEPHROLOGY
巻 14,
号 7,
p. 658-662,
発行日 2009-10
|
| 抄録 |
|
|
内容記述 |
We recently proposed serum sulfatides as a novel biomarker for cardiovascular disease in patients with end-stage renal failure (ESRF), based on the possible antithrombotic properties of this molecule. In this earlier study, the level of serum sulfatides was gradually decreased in parallel with kidney dysfunction; however the precise mechanism underlying this decrease was unknown. The aim of the present study was to investigate the mechanism underlying the decrease in serum sulfatide levels caused by kidney dysfunction in an experimental animal model. To produce a kidney dysfunction animal model, we prepared a mouse model of protein overload nephropathy. Using high-throughput analysis combined with matrix-assisted laser desorption ionisation time-of-flight mass spectrometry, we measured the levels of sulfatides in the sera, livers, small intestines and kidneys of protein overload nephropathy mice. As the disease progressed, the levels of sulfatides in sera decreased. Also, the levels in livers and small intestines decreased in a similar manner to those in sera, to approximately 60% of the original levels. On the contrary, those in kidneys increased by approximately 1.4-fold. Our results indicate that kidney dysfunction affects the levels of sulfatides in lipoprotein-producing organs, such as livers and small intestines, and lowers the levels of sulfatides in sera. |
| 資源タイプ（コンテンツの種類） |
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1320-5358 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11055666 |
| PubMed |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/19796024 |
|
|
関連名称 |
19796024 |
| 権利 |
|
|
権利情報 |
The definitive version is available at wileyonlinelibrary.com |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| WoS |
|
|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000270311700005 |
Kidney_dysfunction_induced_protein_overload_nephropathy_reduces_serum.pdf (646.1 kB)
