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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Cyclic phosphatidic acid decreases proliferation and survival of colon cancer cells by inhibiting peroxisome proliferator-activated receptor gamma

http://hdl.handle.net/10091/16253
http://hdl.handle.net/10091/16253
bfae58b1-309e-4d02-81c4-32e2980f41cf
名前 / ファイル ライセンス アクション
Cyclic_Phosphatidic_Acid_Decreases_Proliferation_Survival.pdf Cyclic_Phosphatidic_Acid_Decreases_Proliferation_Survival.pdf (1.5 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-02-13
タイトル
言語 en
タイトル Cyclic phosphatidic acid decreases proliferation and survival of colon cancer cells by inhibiting peroxisome proliferator-activated receptor gamma
言語
言語 eng
キーワード
主題Scheme Other
主題 Lysophospholipid
キーワード
主題Scheme Other
主題 Nuclear receptor
キーワード
主題Scheme Other
主題 peroxisome proliferator activated receptor gamma
キーワード
主題Scheme Other
主題 Colon cancer
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tsukahara, Tamotsu

× Tsukahara, Tamotsu

WEKO 7245

en Tsukahara, Tamotsu

Search repository
Hanazawa, Shuwa

× Hanazawa, Shuwa

WEKO 7246

en Hanazawa, Shuwa

Search repository
Kobayashi, Tetsuyuki

× Kobayashi, Tetsuyuki

WEKO 7247

en Kobayashi, Tetsuyuki

Search repository
Iwamoto, Yoshiki

× Iwamoto, Yoshiki

WEKO 7248

en Iwamoto, Yoshiki

Search repository
Murakami-Murofushi, Kimiko

× Murakami-Murofushi, Kimiko

WEKO 7249

en Murakami-Murofushi, Kimiko

Search repository
出版者
出版者 ELSEVIER SCIENCE INC
引用
内容記述タイプ Other
内容記述 PROSTAGLANDINS & OTHER LIPID MEDIATORS. 93(3-4):126-133 (2010)
書誌情報 PROSTAGLANDINS & OTHER LIPID MEDIATORS

巻 93, 号 3-4, p. 126-133, 発行日 2010-11
抄録
内容記述タイプ Abstract
内容記述 Cyclic phosphatidic acid (CPA) a structural analog of lysophosphatidic acid (LPA) is one of the simplest phospholipids found in every cell type cPA is a specific high-affinity antagonist of peroxisome proliferator-activated receptor gamma (PPAR gamma) however the molecular mechanism by which cPA inhibits cellular proliferation remains to be clarified In this study we found that inhibition of PPAR gamma prevents proliferation of human colon cancer HT-29 cells CPA suppressed cell growth and this effect was reversed by the addition of a PPAR gamma agonist These results indicate that the physiological effects of cPA are partly due to PPAR gamma inhibition Our results identify PPAR gamma as a molecular mediator of CPA activity in HT-29 cells and suggest that cPA and the PPAR gamma pathway might be therapeutic targets in the treatment of colon cancer
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1098-8823
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11221062
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/20932931
関連名称 20932931
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.prostaglandins.2010.09.002
関連名称 10.1016/j.prostaglandins.2010.09.002
権利
権利情報 Copyright© 2010 Elsevier Inc.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000285233400008
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