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Cyclic phosphatidic acid decreases proliferation and survival of colon cancer cells by inhibiting peroxisome proliferator-activated receptor gamma
http://hdl.handle.net/10091/16253
http://hdl.handle.net/10091/16253bfae58b1-309e-4d02-81c4-32e2980f41cf
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Cyclic_Phosphatidic_Acid_Decreases_Proliferation_Survival.pdf (1.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2013-02-13 | |||||
| タイトル | ||||||
| タイトル | Cyclic phosphatidic acid decreases proliferation and survival of colon cancer cells by inhibiting peroxisome proliferator-activated receptor gamma | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.prostaglandins.2010.09.002 | |||||
| 関連名称 | 10.1016/j.prostaglandins.2010.09.002 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Lysophospholipid | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Nuclear receptor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | peroxisome proliferator activated receptor gamma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Colon cancer | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Tsukahara, Tamotsu
× Tsukahara, Tamotsu× Hanazawa, Shuwa× Kobayashi, Tetsuyuki× Iwamoto, Yoshiki× Murakami-Murofushi, Kimiko |
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| 出版者 | ||||||
| 出版者 | ELSEVIER SCIENCE INC | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PROSTAGLANDINS & OTHER LIPID MEDIATORS. 93(3-4):126-133 (2010) | |||||
| 書誌情報 |
PROSTAGLANDINS & OTHER LIPID MEDIATORS 巻 93, 号 3-4, p. 126-133, 発行日 2010-11 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cyclic phosphatidic acid (CPA) a structural analog of lysophosphatidic acid (LPA) is one of the simplest phospholipids found in every cell type cPA is a specific high-affinity antagonist of peroxisome proliferator-activated receptor gamma (PPAR gamma) however the molecular mechanism by which cPA inhibits cellular proliferation remains to be clarified In this study we found that inhibition of PPAR gamma prevents proliferation of human colon cancer HT-29 cells CPA suppressed cell growth and this effect was reversed by the addition of a PPAR gamma agonist These results indicate that the physiological effects of cPA are partly due to PPAR gamma inhibition Our results identify PPAR gamma as a molecular mediator of CPA activity in HT-29 cells and suggest that cPA and the PPAR gamma pathway might be therapeutic targets in the treatment of colon cancer | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1098-8823 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11221062 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/20932931 | |||||
| 関連名称 | 20932931 | |||||
| 権利 | ||||||
| 権利情報 | Copyright© 2010 Elsevier Inc. | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000285233400008 | |||||
