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Cyclic phosphatidic acid influences the expression and regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 cells
http://hdl.handle.net/10091/16252
http://hdl.handle.net/10091/16252ad1bf790-eecf-4e55-bf1c-062922fa2a10
| 名前 / ファイル | ライセンス | アクション |
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Cyclic_Phosphatidic_Acid_Influences_Expression_Regulation_Cyclic_Nucleotide.pdf (1.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2013-02-13 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Cyclic phosphatidic acid influences the expression and regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 cells | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| DOI | ||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.bbrc.2010.11.076 | |||||||||||
| 関連名称 | 10.1016/j.bbrc.2010.11.076 | |||||||||||
| キーワード | ||||||||||||
| 主題 | Lysophospholipids, Cyclic phosphatidic acid, PPAR gamma, Adipogenesis, Phosphodiesterase, Lipolysis | |||||||||||
| 資源タイプ | ||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| タイプ | journal article | |||||||||||
| 著者 |
Tsukahara, Tamotsu
× Tsukahara, Tamotsu
× Hanazawa, Shuwa
× Murakami-Murofushi, Kimiko
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| 出版者 | ||||||||||||
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE | |||||||||||
| 引用 | ||||||||||||
| 内容記述 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 404(1):109-114 (2011) | |||||||||||
| 書誌情報 |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 巻 404, 号 1, p. 109-114, 発行日 2011-01-07 |
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| 抄録 | ||||||||||||
| 内容記述 | Cyclic phosphatidic acid (CPA) is found in cells from slime mold to humans and has a largely unknown function. We previously reported that cPA significantly inhibited the lipid accumulation in 3T3-L1 adipocytes through inhibition of PPAR gamma activation. We find here that CPA reduced intracellular triglyceride levels and inhibited the phosphodiesterase 3B (PDE3B) expression in 3T3-L1 adipocytes. PPAR gamma activation in adipogenesis that can be blocked by treatment with cPA then participates in adipocyte function through inhibition of PDE3B expression. We also found the intracellular cAMP levels in 3T3-L1 adipocytes increased after exposure to cPA. These findings contribute to the participation of cPA on the lipolytic activity in 3T3-L1 adipocytes. Our studies imply that CPA might be a therapeutic compound in the treatment of obesity and obesity-related diseases. | |||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 0006-291X | |||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA00564395 | |||||||||||
| PubMed | ||||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/21095182 | |||||||||||
| 関連名称 | 21095182 | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | Copyright© 2010 Elsevier Inc. | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | AM | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||
| WoS | ||||||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000286487700020 | |||||||||||
