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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Cyclic phosphatidic acid influences the expression and regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 cells

http://hdl.handle.net/10091/16252
http://hdl.handle.net/10091/16252
ad1bf790-eecf-4e55-bf1c-062922fa2a10
名前 / ファイル ライセンス アクション
Cyclic_Phosphatidic_Acid_Influences_Expression_Regulation_Cyclic_Nucleotide.pdf Cyclic_Phosphatidic_Acid_Influences_Expression_Regulation_Cyclic_Nucleotide.pdf (1.7 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-02-13
タイトル
言語 en
タイトル Cyclic phosphatidic acid influences the expression and regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 cells
言語
言語 eng
キーワード
主題Scheme Other
主題 Lysophospholipids
キーワード
主題Scheme Other
主題 Cyclic phosphatidic acid
キーワード
主題Scheme Other
主題 PPAR gamma
キーワード
主題Scheme Other
主題 Adipogenesis
キーワード
主題Scheme Other
主題 Phosphodiesterase
キーワード
主題Scheme Other
主題 Lipolysis
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tsukahara, Tamotsu

× Tsukahara, Tamotsu

WEKO 7250

en Tsukahara, Tamotsu

Search repository
Hanazawa, Shuwa

× Hanazawa, Shuwa

WEKO 7251

en Hanazawa, Shuwa

Search repository
Murakami-Murofushi, Kimiko

× Murakami-Murofushi, Kimiko

WEKO 7252

en Murakami-Murofushi, Kimiko

Search repository
出版者
出版者 ACADEMIC PRESS INC ELSEVIER SCIENCE
引用
内容記述タイプ Other
内容記述 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 404(1):109-114 (2011)
書誌情報 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

巻 404, 号 1, p. 109-114, 発行日 2011-01-07
抄録
内容記述タイプ Abstract
内容記述 Cyclic phosphatidic acid (CPA) is found in cells from slime mold to humans and has a largely unknown function. We previously reported that cPA significantly inhibited the lipid accumulation in 3T3-L1 adipocytes through inhibition of PPAR gamma activation. We find here that CPA reduced intracellular triglyceride levels and inhibited the phosphodiesterase 3B (PDE3B) expression in 3T3-L1 adipocytes. PPAR gamma activation in adipogenesis that can be blocked by treatment with cPA then participates in adipocyte function through inhibition of PDE3B expression. We also found the intracellular cAMP levels in 3T3-L1 adipocytes increased after exposure to cPA. These findings contribute to the participation of cPA on the lipolytic activity in 3T3-L1 adipocytes. Our studies imply that CPA might be a therapeutic compound in the treatment of obesity and obesity-related diseases.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0006-291X
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00564395
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/21095182
関連名称 21095182
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.bbrc.2010.11.076
関連名称 10.1016/j.bbrc.2010.11.076
権利
権利情報 Copyright© 2010 Elsevier Inc.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000286487700020
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