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Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells
http://hdl.handle.net/10091/16248
http://hdl.handle.net/10091/16248dc1790c0-ffe1-4f1b-a590-93930e50d0ee
| 名前 / ファイル | ライセンス | アクション |
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Cellular_Cytotoxic_Response_Induced_Highly_Purified.pdf (962.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2013-02-13 | |||||||||
| タイトル | ||||||||||
| タイトル | Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| DOI | ||||||||||
| 関連識別子 | https://doi.org/10.1007/s11010-011-0739-z | |||||||||
| 関連名称 | 10.1007/s11010-011-0739-z | |||||||||
| キーワード | ||||||||||
| 主題 | Multi-wall carbon nanotube, Cellular uptake, Cytokine release, Bronchial epithelial cells, Necrosis | |||||||||
| 資源タイプ | ||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| タイプ | journal article | |||||||||
| 著者 |
Tsukahara, Tamotsu
× Tsukahara, Tamotsu
× Haniu, Hisao
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| 信州大学研究者総覧へのリンク | ||||||||||
| 氏名 | Haniu, Hisao | |||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html | |||||||||
| 出版者 | ||||||||||
| 出版者 | SPRINGER | |||||||||
| 引用 | ||||||||||
| 内容記述 | MOLECULAR AND CELLULAR BIOCHEMISTRY. 352(1-2):57-63 (2011) | |||||||||
| 書誌情報 |
MOLECULAR AND CELLULAR BIOCHEMISTRY 巻 352, 号 1-2, p. 57-63, 発行日 2011-06 |
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| 抄録 | ||||||||||
| 内容記述 | Carbon nanotubes, a promising nanomaterial with unique characteristics, have applications in a variety of fields. The cytotoxic effects of carbon nanotubes are partially due to the induction of oxidative stress; however, the detailed mechanisms of nanotube cytotoxicity and their interaction with cells remain unclear. In this study, the authors focus on the acute toxicity of vapor-grown carbon fiber, HTT2800, which is one of the most highly purified multi-wall carbon nanotubes (MWCNT) by high-temperature thermal treatment. The authors exposed human bronchial epithelial cells (BEAS-2B) to HTT2800 and measured the cellular uptake, mitochondrial function, cellular LDH release, apoptotic signaling, reactive oxygen species (ROS) generation and pro-inflammatory cytokine release. The HTT2800-exposed cells showed cellular uptake of the carbon nanotube, increased cell death, enhanced DNA damage, and induced cytokine release. However, the exposed cells showed no obvious intracellular ROS generation. These cellular and molecular findings suggest that HTT2800 could cause a potentially adverse inflammatory response in BEAS-2B cells. | |||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 0300-8177 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00745800 | |||||||||
| PubMed | ||||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/21298324 | |||||||||
| 関連名称 | 21298324 | |||||||||
| 権利 | ||||||||||
| 権利情報 | The final publication is available at www.springerlink.com | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| WoS | ||||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000290688500007 | |||||||||
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Cite as
Tsukahara, Tamotsu, Haniu, Hisao, 2011, Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells: SPRINGER, 57–63 p.
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