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Serum interleukin (IL)-10 and IL-12 levels and IL28B gene polymorphisms: pretreatment prediction of treatment failure in chronic hepatitis C
http://hdl.handle.net/10091/16246
http://hdl.handle.net/10091/162468df3be8e-3276-41cb-96cb-f5299172e94e
| 名前 / ファイル | ライセンス | アクション |
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Serum_IL-10_IL-12p40_levels_IL28B_Gene_Polymorphisms.pdf (639.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
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| 公開日 | 2013-02-13 | |||||||||||||||||||||||
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| タイトル | Serum interleukin (IL)-10 and IL-12 levels and IL28B gene polymorphisms: pretreatment prediction of treatment failure in chronic hepatitis C | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3851/IMP1869 | |||||||||||||||||||||||
| 関連名称 | 10.3851/IMP1869 | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||||||
| 著者 |
Umemura, Takeji
× Umemura, Takeji
× Joshita, Satoru
× Yoneda, Suguru
× Katsuyama, Yoshihiko
× Ichijo, Tetsuya
× Matsumoto, Akihiro
× Yoshizawa, Kaname
× Ota, Masao
× Tanaka, Eiji
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | Umemura, Takeji | |||||||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html | |||||||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | Joshita, Satoru | |||||||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.PeLNbVym.html | |||||||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | Ota, Masao | |||||||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html | |||||||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | Tanaka, Eiji | |||||||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | INT MEDICAL PRESS LTD | |||||||||||||||||||||||
| 引用 | ||||||||||||||||||||||||
| 内容記述 | ANTIVIRAL THERAPY. 16(7):1073-1080 (2011) | |||||||||||||||||||||||
| 書誌情報 |
ANTIVIRAL THERAPY 巻 16, 号 7, p. 1073-1080, 発行日 2011 |
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| 抄録 | ||||||||||||||||||||||||
| 内容記述 | Background: Both IL28B gene polymorphisms and serum levels of interleukin (IL)-10, IL-12p40 and IL-18 have been reported to affect the outcome of natural and pegylated interferon and ribavirin-treated HCV infection. Methods: To clarify their association and predictive value in treatment outcome of genotype 1 HCV-infected patients, we measured pretreatment serum IL-10, IL-12p40 and IL-18 levels using multiplex assays and determined IL28B gene polymorphisms (rs 8099917) in 52 cases with chronic hepatitis C. Results: High baseline levels of IL-10 (P<0.001) and low levels of IL-12p40 (P<0.001) were significantly associated with a non-virological response (NVR) in our cohort. The IL28B polymorphism was tested and TT, TG or GG genotypes were found in 60%, 38% and 2% of patients, respectively, with corresponding NVR rates of 10%, 60% and 100% (P<0.001). Serum cytokine levels were significantly correlated with IL28B gene polymorphisms. When serum IL-10 levels were stratified at 5.0 pg/ml, NVR rates were 50% versus 0% (P=0.004) for the IT genotype and 87% versus 0% (P=0.001) for the TG or GG genotypes. Similarly, low IL-12p40 levels were associated with an NVR in patients with TG or GG genotypes (P=0.006). In multivariate analysis, high IL-10, low IL-12p40 and IL28B TG or GG genotypes were independently associated with an NVR. Conclusions: Serum IL-10 and IL-12p40 levels in combination with IL28B genotype, especially G-allele carriage, are strong predictive markers of an NVR to HCV treatment with pegylated interferon and ribavirin. | |||||||||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||||||||
| ISSN | ||||||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||||||
| 収録物識別子 | 1359-6535 | |||||||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA11642446 | |||||||||||||||||||||||
| PubMed | ||||||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/22024523 | |||||||||||||||||||||||
| 関連名称 | 22024523 | |||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||
| 権利情報 | This is the author�fs version of a work accepted for publication by International Medical Press. Changes resulting from the publishing process, including peer review, editing and formatting, might not be reflected in this document. A definitive version was published in Antiviral Therapy, Vol. 16, 29 July 2011, Copyright© 2011 International Medical Press | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||
| WoS | ||||||||||||||||||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000296941900016 | |||||||||||||||||||||||
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Umemura, Takeji, Joshita, Satoru, Yoneda, Suguru, Katsuyama, Yoshihiko, Ichijo, Tetsuya, Matsumoto, Akihiro, Yoshizawa, Kaname, Ota, Masao, Tanaka, Eiji, 2011, Serum interleukin (IL)-10 and IL-12 levels and IL28B gene polymorphisms: pretreatment prediction of treatment failure in chronic hepatitis C: INT MEDICAL PRESS LTD, 1073–1080 p.
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