Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2013-02-13 |
タイトル |
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タイトル |
Serum interleukin (IL)-10 and IL-12 levels and IL28B gene polymorphisms: pretreatment prediction of treatment failure in chronic hepatitis C |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.3851/IMP1869 |
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関連名称 |
10.3851/IMP1869 |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Umemura, Takeji
Joshita, Satoru
Yoneda, Suguru
Katsuyama, Yoshihiko
Ichijo, Tetsuya
Matsumoto, Akihiro
Yoshizawa, Kaname
Ota, Masao
Tanaka, Eiji
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信州大学研究者総覧へのリンク |
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氏名 |
Umemura, Takeji |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Joshita, Satoru |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.PeLNbVym.html |
信州大学研究者総覧へのリンク |
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氏名 |
Ota, Masao |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Tanaka, Eiji |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html |
出版者 |
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出版者 |
INT MEDICAL PRESS LTD |
引用 |
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内容記述 |
ANTIVIRAL THERAPY. 16(7):1073-1080 (2011) |
書誌情報 |
ANTIVIRAL THERAPY
巻 16,
号 7,
p. 1073-1080,
発行日 2011
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抄録 |
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内容記述 |
Background: Both IL28B gene polymorphisms and serum levels of interleukin (IL)-10, IL-12p40 and IL-18 have been reported to affect the outcome of natural and pegylated interferon and ribavirin-treated HCV infection. Methods: To clarify their association and predictive value in treatment outcome of genotype 1 HCV-infected patients, we measured pretreatment serum IL-10, IL-12p40 and IL-18 levels using multiplex assays and determined IL28B gene polymorphisms (rs 8099917) in 52 cases with chronic hepatitis C. Results: High baseline levels of IL-10 (P<0.001) and low levels of IL-12p40 (P<0.001) were significantly associated with a non-virological response (NVR) in our cohort. The IL28B polymorphism was tested and TT, TG or GG genotypes were found in 60%, 38% and 2% of patients, respectively, with corresponding NVR rates of 10%, 60% and 100% (P<0.001). Serum cytokine levels were significantly correlated with IL28B gene polymorphisms. When serum IL-10 levels were stratified at 5.0 pg/ml, NVR rates were 50% versus 0% (P=0.004) for the IT genotype and 87% versus 0% (P=0.001) for the TG or GG genotypes. Similarly, low IL-12p40 levels were associated with an NVR in patients with TG or GG genotypes (P=0.006). In multivariate analysis, high IL-10, low IL-12p40 and IL28B TG or GG genotypes were independently associated with an NVR. Conclusions: Serum IL-10 and IL-12p40 levels in combination with IL28B genotype, especially G-allele carriage, are strong predictive markers of an NVR to HCV treatment with pegylated interferon and ribavirin. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1359-6535 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11642446 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/22024523 |
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関連名称 |
22024523 |
権利 |
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権利情報 |
This is the author�fs version of a work accepted for publication by International Medical Press. Changes resulting from the publishing process, including peer review, editing and formatting, might not be reflected in this document. A definitive version was published in Antiviral Therapy, Vol. 16, 29 July 2011, Copyright© 2011 International Medical Press |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000296941900016 |