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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Serum interleukin (IL)-10 and IL-12 levels and IL28B gene polymorphisms: pretreatment prediction of treatment failure in chronic hepatitis C

http://hdl.handle.net/10091/16246
http://hdl.handle.net/10091/16246
8df3be8e-3276-41cb-96cb-f5299172e94e
名前 / ファイル ライセンス アクション
Serum_IL-10_IL-12p40_levels_IL28B_Gene_Polymorphisms.pdf Serum_IL-10_IL-12p40_levels_IL28B_Gene_Polymorphisms.pdf (639.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-02-13
タイトル
タイトル Serum interleukin (IL)-10 and IL-12 levels and IL28B gene polymorphisms: pretreatment prediction of treatment failure in chronic hepatitis C
言語
言語 eng
DOI
関連識別子 https://doi.org/10.3851/IMP1869
関連名称 10.3851/IMP1869
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Umemura, Takeji

× Umemura, Takeji

en Umemura, Takeji

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Joshita, Satoru

× Joshita, Satoru

en Joshita, Satoru

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Yoneda, Suguru

× Yoneda, Suguru

en Yoneda, Suguru

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Katsuyama, Yoshihiko

× Katsuyama, Yoshihiko

en Katsuyama, Yoshihiko

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Ichijo, Tetsuya

× Ichijo, Tetsuya

en Ichijo, Tetsuya

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Matsumoto, Akihiro

× Matsumoto, Akihiro

en Matsumoto, Akihiro

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Yoshizawa, Kaname

× Yoshizawa, Kaname

en Yoshizawa, Kaname

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Ota, Masao

× Ota, Masao

en Ota, Masao

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Tanaka, Eiji

× Tanaka, Eiji

en Tanaka, Eiji

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信州大学研究者総覧へのリンク
氏名 Umemura, Takeji
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html
信州大学研究者総覧へのリンク
氏名 Joshita, Satoru
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.PeLNbVym.html
信州大学研究者総覧へのリンク
氏名 Ota, Masao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html
信州大学研究者総覧へのリンク
氏名 Tanaka, Eiji
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html
出版者
出版者 INT MEDICAL PRESS LTD
引用
内容記述 ANTIVIRAL THERAPY. 16(7):1073-1080 (2011)
書誌情報 ANTIVIRAL THERAPY

巻 16, 号 7, p. 1073-1080, 発行日 2011
抄録
内容記述 Background: Both IL28B gene polymorphisms and serum levels of interleukin (IL)-10, IL-12p40 and IL-18 have been reported to affect the outcome of natural and pegylated interferon and ribavirin-treated HCV infection. Methods: To clarify their association and predictive value in treatment outcome of genotype 1 HCV-infected patients, we measured pretreatment serum IL-10, IL-12p40 and IL-18 levels using multiplex assays and determined IL28B gene polymorphisms (rs 8099917) in 52 cases with chronic hepatitis C. Results: High baseline levels of IL-10 (P<0.001) and low levels of IL-12p40 (P<0.001) were significantly associated with a non-virological response (NVR) in our cohort. The IL28B polymorphism was tested and TT, TG or GG genotypes were found in 60%, 38% and 2% of patients, respectively, with corresponding NVR rates of 10%, 60% and 100% (P<0.001). Serum cytokine levels were significantly correlated with IL28B gene polymorphisms. When serum IL-10 levels were stratified at 5.0 pg/ml, NVR rates were 50% versus 0% (P=0.004) for the IT genotype and 87% versus 0% (P=0.001) for the TG or GG genotypes. Similarly, low IL-12p40 levels were associated with an NVR in patients with TG or GG genotypes (P=0.006). In multivariate analysis, high IL-10, low IL-12p40 and IL28B TG or GG genotypes were independently associated with an NVR. Conclusions: Serum IL-10 and IL-12p40 levels in combination with IL28B genotype, especially G-allele carriage, are strong predictive markers of an NVR to HCV treatment with pegylated interferon and ribavirin.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 1359-6535
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11642446
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/22024523
関連名称 22024523
権利
権利情報 This is the author�fs version of a work accepted for publication by International Medical Press. Changes resulting from the publishing process, including peer review, editing and formatting, might not be reflected in this document. A definitive version was published in Antiviral Therapy, Vol. 16, 29 July 2011, Copyright© 2011 International Medical Press
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000296941900016
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