Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2013-02-13 |
タイトル |
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タイトル |
Association of Serum Cytokine Levels With Treatment Response to Pegylated Interferon and Ribavirin Therapy in Genotype 1 Chronic Hepatitis C Patients |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1093/infdis/jiq165 |
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関連名称 |
10.1093/infdis/jiq165 |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Yoneda, Suguru
Umemura, Takeji
Katsuyama, Yoshihiko
Kamijo, Atsushi
Joshita, Satoru
Komatsu, Michiharu
Ichijo, Tetsuya
Matsumoto, Akihiro
Yoshizawa, Kaname
Ota, Masao
Tanaka, Eiji
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信州大学研究者総覧へのリンク |
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氏名 |
Umemura, Takeji |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Joshita, Satoru |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.PeLNbVym.html |
信州大学研究者総覧へのリンク |
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氏名 |
Ota, Masao |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Tanaka, Eiji |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html |
出版者 |
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出版者 |
OXFORD UNIV PRESS INC |
引用 |
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内容記述 |
JOURNAL OF INFECTIOUS DISEASES. 203(8):1087-1095 (2011) |
書誌情報 |
JOURNAL OF INFECTIOUS DISEASES
巻 203,
号 8,
p. 1087-1095,
発行日 2011-04-15
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抄録 |
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内容記述 |
Methods. We quantified a total of 8 serum cytokines before, during, and after treatment in 79 genotype 1 chronic HCV patients. Viral ISDR and core region variants were determined by direct sequencing. Results. High levels of interleukin (IL)-12 and IL-18 and more than 2 mutations in the ISDR were associated with a sustained virological response (SVR). Conversely, high baseline IL-10 levels and glutamine at amino acid 70 of the HCV core protein (Gln70) were significantly associated with a nonresponse to treatment, and patients with Gln70 had significantly higher IL-10 levels. In multivariate analysis, low IL-10, high IL-12, and high IL-18 levels were independently associated with an SVR. These 3 cytokine levels were decreased from baseline levels 4 weeks into treatment and remained low in patients with an SVR. Conclusion. Serum IL-10, IL-12, and IL-18 levels are predictive of the response to HCV treatment with pegylated interferon and ribavirin and are associated with amino acid substitutions in the ISDR and core region. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0022-1899 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA0070010X |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/21398397 |
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関連名称 |
21398397 |
権利 |
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権利情報 |
Copyright© The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. |
権利 |
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権利情報 |
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in J Infect Dis. following peer review. The definitive publisher-authenticated version J Infect Dis. (2011) 203 (8): 1087-1095 is available online at: doi: 10.1093/infdis/jiq165 |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000289168500008 |