| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-02-13 |
| タイトル |
|
|
タイトル |
Serum chemokine levels are associated with the outcome of pegylated interferon and ribavirin therapy in patients with chronic hepatitis C |
| 言語 |
|
|
言語 |
eng |
| DOI |
|
|
|
関連識別子 |
https://doi.org/10.1111/j.1872-034X.2011.00802.x |
|
|
関連名称 |
10.1111/j.1872-034X.2011.00802.x |
| キーワード |
|
|
主題 |
chemokines, core, interferon sensitivity determining region, MIP-1 beta, pegylated interferon, ribavirin |
| 資源タイプ |
|
|
資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Yoneda, Suguru
Umemura, Takeji
Joshita, Satoru
Ichijo, Tetsuya
Matsumoto, Akihiro
Yoshizawa, Kaname
Katsuyama, Yoshihiko
Ota, Masao
Tanaka, Eiji
|
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Umemura, Takeji |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Joshita, Satoru |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.PeLNbVym.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Ota, Masao |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Tanaka, Eiji |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html |
| 出版者 |
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出版者 |
WILEY-BLACKWELL |
| 引用 |
|
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内容記述 |
HEPATOLOGY RESEARCH. 41(6):587-593 (2011) |
| 書誌情報 |
HEPATOLOGY RESEARCH
巻 41,
号 6,
p. 587-593,
発行日 2011-06
|
| 抄録 |
|
|
内容記述 |
Aim: Serum chemokine levels and amino acid substitutions in the interferon-sensitivity determining region (ISDR) and core region have been associated with treatment outcome of pegylated interferon and ribavirin therapy in genotype 1 hepatitis C virus (HCV)-infected patients. The present study was conducted to clarify the association between serum chemokines and treatment outcome in patients with chronic HCV-1 infection in a Japanese cohort. Methods: A total of six serum chemokines were quantified before, during and after pegylated interferon and ribavirin treatment in 79 genotype 1 chronic HCV patients using a multiple bead array system. Viral ISDR and core region variants were determined by direct sequencing. Results: The baseline serum levels of eotaxin, IP-10 and RANTES were significantly higher in chronic HCV patients than in controls. High levels of eotaxin and macrophage inflammatory protein (MIP)-1 beta before therapy and more than two mutations in the ISDR were associated with a sustained virological response, and patients with more than two mutations in the ISDR also had significantly higher MIP-1 beta levels. Receiver-operator curve analysis showed a 77% sensitivity and 73% specificity for predicting an SVR using MIP-1 beta values. Conclusion: Serum MIP-1 beta levels may predict the response to HCV treatment with pegylated interferon and ribavirin and are associated with amino acid substitutions in the ISDR. |
| 資源タイプ（コンテンツの種類） |
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1386-6346 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11140867 |
| PubMed |
|
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/21504519 |
|
|
関連名称 |
21504519 |
| 権利 |
|
|
権利情報 |
The definitive version is available at www.blackwell-synergy.com |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| WoS |
|
|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000290963400012 |
Serum_Chemokine_Levels_Are_Associated_Outcome_ Pegylated_Interferon.pdf (210.2 kB)
