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To assess whether the IL28B rs8099917 SNP also affects the progression of chronic HCV infection, we genotyped 511 Japanese HCV patients, including 69 with hepatocellular carcinoma (HCC). The T/T genotype of rs8099917 was not associated with the development of HCC (p = 0.623), although stepwise logistic regression analysis showed that liver cirrhosis, age greater than 68 years, and serum albumin \u003c4.2 mg/dl were associated with HCC onset. It appears that the IL28B SNP does not directly influence hepatocarcinogenesis in chronic HCV infection. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. 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Association of IL28B gene polymorphism with development of hepatocellular carcinoma in Japanese patients with chronic hepatitis C virus infection
http://hdl.handle.net/10091/16243
a6a39449-2c57-467f-ac7c-d4dd2518389e
名前 / ファイル | ライセンス | Actions | |
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item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-02-13 | |||||
タイトル | ||||||
タイトル | Association of IL28B gene polymorphism with development of hepatocellular carcinoma in Japanese patients with chronic hepatitis C virus infection | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | IL28B | |||||
キーワード | ||||||
主題 | SNP | |||||
キーワード | ||||||
主題 | HCC | |||||
キーワード | ||||||
主題 | HCV | |||||
キーワード | ||||||
主題 | Cirrhosis | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Joshita, Satoru
× Joshita, Satoru× Umemura, Takeji× Katsuyama, Yoshihiko× Ichikawa, Yuki× Kimura, Takefumi× Morita, Susumu× Kamijo, Atsushi× Komatsu, Michiharu× Ichijo, Tetsuya× Matsumoto, Akihiro× Yoshizawa, Kaname× Kamijo, Nozomi× Ota, Masao× Tanaka, Eiji |
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信州大学研究者総覧へのリンク | ||||||
Joshita, Satoru | ||||||
http://soar-rd.shinshu-u.ac.jp/profile/ja.PeLNbVym.html | ||||||
信州大学研究者総覧へのリンク | ||||||
Umemura, Takeji | ||||||
http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html | ||||||
信州大学研究者総覧へのリンク | ||||||
Ota, Masao | ||||||
http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html | ||||||
信州大学研究者総覧へのリンク | ||||||
Tanaka, Eiji | ||||||
http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html | ||||||
出版者 | ||||||
出版者 | ELSEVIER SCIENCE INC | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | HUMAN IMMUNOLOGY. 73(3):298-300 (2012) | |||||
書誌情報 |
HUMAN IMMUNOLOGY 巻 73, 号 3, p. 298-300, 発行日 2012-03 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | IL28B single nucleotide polymorphisms (SNPs) are associated with spontaneous and treatment-induced elimination of hepatitis C virus (HCV). To assess whether the IL28B rs8099917 SNP also affects the progression of chronic HCV infection, we genotyped 511 Japanese HCV patients, including 69 with hepatocellular carcinoma (HCC). The T/T genotype of rs8099917 was not associated with the development of HCC (p = 0.623), although stepwise logistic regression analysis showed that liver cirrhosis, age greater than 68 years, and serum albumin <4.2 mg/dl were associated with HCC onset. It appears that the IL28B SNP does not directly influence hepatocarcinogenesis in chronic HCV infection. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0198-8859 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00214087 | |||||
PubMed | ||||||
関連識別子 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=22245236 | |||||
関連名称 | ||||||
関連名称 | 22245236 | |||||
DOI | ||||||
関連識別子 | ||||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.1016/j.humimm.2011.12.021 | |||||
関連名称 | ||||||
関連名称 | 10.1016/j.humimm.2011.12.021 | |||||
権利 | ||||||
権利情報 | Copyright© 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. | |||||
著者版フラグ | ||||||
値 | author | |||||
WoS | ||||||
Web of Science | ||||||
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000300964400014 |