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Expression of Long-form N-Acetylglucosamine-6-O-Sulfotransferase 1 in Human High Endothelial Venules
http://hdl.handle.net/10091/16234
http://hdl.handle.net/10091/16234f36ec7e0-4b0f-4561-92e7-4a9de4820f3b
| 名前 / ファイル | ライセンス | アクション |
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Expression_Long-Form_N-Acetylglucosamine-6-O-Sulfotransferase_1_Human_High.pdf (1.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
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| 公開日 | 2013-02-04 | |||||||||||||||||||||||
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| タイトル | Expression of Long-form N-Acetylglucosamine-6-O-Sulfotransferase 1 in Human High Endothelial Venules | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1369/0022155412437613 | |||||||||||||||||||||||
| 関連名称 | 10.1369/0022155412437613 | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 主題 | N-acetylglucosamine-6-O-sulfotransferase 1 (GlcNAc6ST-1), long form, high endothelial venule (HEV) | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||||||
| 著者 |
Fujiwara, Maiko
× Fujiwara, Maiko
× Kobayashi, Motohiro
× Hoshino, Hitomi
× Uchimura, Kenji
× Nakada, Tsutomu
× Masumoto, Junya
× Sakai, Yasuhiro
× Fukuda, Minoru
× Nakayama, Jun
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | Nakada, Tsutomu | |||||||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OVkhuNkh.html | |||||||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||
| 氏名 | Nakayama, Jun | |||||||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HCApHFkh.html | |||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||
| 出版者 | SAGE PUBLICATIONS LTD | |||||||||||||||||||||||
| 引用 | ||||||||||||||||||||||||
| 内容記述 | JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. 60(5):397-407 (2012) | |||||||||||||||||||||||
| 書誌情報 |
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 巻 60, 号 5, p. 397-407, 発行日 2012-05 |
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| 抄録 | ||||||||||||||||||||||||
| 内容記述 | Two members of the N-acetylglucosamine-6-O-sulfotransferase (GlcNAc6ST) family, GlcNAc6ST-1 and GlcNAc6ST-2, function in the biosynthesis of 6-sulfo sialyl Lewis X-capped glycoproteins expressed on high endothelial venules (HEVs) in secondary lymphoid organs. Thus, both enzymes play a critical role in L-selectin-expressing lymphocyte homing. Human GlcNAc6ST-1 is encoded by a 1593-bp open reading frame exhibiting two 5' in-frame methionine codons spaced 141 bp apart. Both resemble the consensus sequence for translation initiation. Thus, it has been hypothesized that both long and short forms of GlcNAc6ST-1 may be present, although endogenous expression of either form has not been confirmed in humans. Here, the authors developed an antibody recognizing amino acid residues between the first two human GlcNAc6ST-1 methionines. This antibody specifically recognizes the long form of the enzyme, a finding validated by Western blot analysis and immunofluorescence cytochemistry of HeLa cells misexpressing long and/or short forms of human GlcNAc6ST-1. Using this antibody, the authors carried out immunofluorescence histochemistry of human lymph node tissue sections and found endogenous expression of the long form of the enzyme in human tissue, predominantly in the trans-Golgi network of endothelial cells that form HEVs. (J Histochem Cytochem 60:397-407, 2012) | |||||||||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||||||||
| ISSN | ||||||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||||||
| 収録物識別子 | 0022-1554 | |||||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||||
| 収録物識別子 | AA0069926X | |||||||||||||||||||||||
| PubMed | ||||||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/22260995 | |||||||||||||||||||||||
| 関連名称 | 22260995 | |||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||
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| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000303239300006 | |||||||||||||||||||||||
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Fujiwara, Maiko, Kobayashi, Motohiro, Hoshino, Hitomi, Uchimura, Kenji, Nakada, Tsutomu, Masumoto, Junya, Sakai, Yasuhiro, Fukuda, Minoru, Nakayama, Jun, 2012, Expression of Long-form N-Acetylglucosamine-6-O-Sulfotransferase 1 in Human High Endothelial Venules: SAGE PUBLICATIONS LTD, 397–407 p.
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