Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2012-09-21 |
タイトル |
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タイトル |
The Microenvironment of Freeze-Injured Mouse Urinary Bladders Enables Successful Tissue Engineering |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1089/ten.tea.2009.0038 |
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関連名称 |
10.1089/ten.tea.2009.0038 |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Imamura, Tetsuya
Yamamoto, Tokunori
Ishizuka, Osamu
Gotoh, Momokazu
Nishizawa, Osamu
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信州大学研究者総覧へのリンク |
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氏名 |
Imamura, Tetsuya |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ypACOmyC.html |
信州大学研究者総覧へのリンク |
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氏名 |
Nishizawa, Osamu |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html |
出版者 |
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出版者 |
MARY ANN LIEBERT INC |
引用 |
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内容記述 |
TISSUE ENGINEERING PART A. 15(11):3367-3375 (2009) |
書誌情報 |
TISSUE ENGINEERING PART A
巻 15,
号 11,
p. 3367-3375,
発行日 2009-11
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抄録 |
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内容記述 |
Mouse bone marrow-derived cells implanted into freeze-injured bladder walls form smooth muscle layers, but not in intact walls. We determined if the microenvironment within injured urinary bladders was supportive of smooth muscle layer development. The urinary bladders of female nude mice were freeze-injured for 30 s. Three days later, the rate of blood flow in the wounded areas and in comparable areas of intact control urinary bladders was observed by charge-coupled device (CCD) video microscopy. Injured and control bladder walls were also analyzed histologically and cytologically. Growth factor mRNA expression was determined by real-time reverse transcription polymerase chain reaction arrays. The injured regions maintained a partial microcirculation in which blood flow velocity was significantly less than in controls. The injured bladder walls had few typical smooth muscle layers, and blood vessels in the walls had reduced smooth muscle content. The loss of smooth muscle cells in the bladder walls may have resulted in the formation of large porous spaces seen by scanning electron microscopy of the injured areas. The expression of nineteen growth-related mRNAs, including secreted phosphoprotein 1, inhibin beta-A, glial cell line-derived neurotrophic factor, and transforming growth factor beta 1, were significantly upregulated in the injured urinary bladders. In conclusion, the microenvironment in freeze-injured urinary bladders enables successful tissue engineering. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1937-3341 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12306003 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/19397471 |
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関連名称 |
19397471 |
権利 |
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権利情報 |
This is a copy of an article published in the TISSUE ENGINEERING PART A. Copyright© 2009 Mary Ann Liebert, Inc.; TISSUE ENGINEERING PART A is available online at: http://online.liebertpub.com. |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000271746800015 |