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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

The Microenvironment of Freeze-Injured Mouse Urinary Bladders Enables Successful Tissue Engineering

http://hdl.handle.net/10091/15979
82f3c5f6-db3e-4d97-bc2a-9996bbed1da6
名前 / ファイル ライセンス アクション
TEA TEA 2009 15 3367.pdf (506.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2012-09-21
タイトル
言語 en
タイトル The Microenvironment of Freeze-Injured Mouse Urinary Bladders Enables Successful Tissue Engineering
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Imamura, Tetsuya

× Imamura, Tetsuya

WEKO 7441

en Imamura, Tetsuya

Search repository
Yamamoto, Tokunori

× Yamamoto, Tokunori

WEKO 7442

en Yamamoto, Tokunori

Search repository
Ishizuka, Osamu

× Ishizuka, Osamu

WEKO 7443

en Ishizuka, Osamu

Search repository
Gotoh, Momokazu

× Gotoh, Momokazu

WEKO 7444

en Gotoh, Momokazu

Search repository
Nishizawa, Osamu

× Nishizawa, Osamu

WEKO 7445

en Nishizawa, Osamu

Search repository
信州大学研究者総覧へのリンク
氏名 Imamura, Tetsuya
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ypACOmyC.html
信州大学研究者総覧へのリンク
氏名 Nishizawa, Osamu
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html
出版者
出版者 MARY ANN LIEBERT INC
引用
内容記述タイプ Other
内容記述 TISSUE ENGINEERING PART A. 15(11):3367-3375 (2009)
書誌情報 TISSUE ENGINEERING PART A

巻 15, 号 11, p. 3367-3375, 発行日 2009-11
抄録
内容記述タイプ Abstract
内容記述 Mouse bone marrow-derived cells implanted into freeze-injured bladder walls form smooth muscle layers, but not in intact walls. We determined if the microenvironment within injured urinary bladders was supportive of smooth muscle layer development. The urinary bladders of female nude mice were freeze-injured for 30 s. Three days later, the rate of blood flow in the wounded areas and in comparable areas of intact control urinary bladders was observed by charge-coupled device (CCD) video microscopy. Injured and control bladder walls were also analyzed histologically and cytologically. Growth factor mRNA expression was determined by real-time reverse transcription polymerase chain reaction arrays. The injured regions maintained a partial microcirculation in which blood flow velocity was significantly less than in controls. The injured bladder walls had few typical smooth muscle layers, and blood vessels in the walls had reduced smooth muscle content. The loss of smooth muscle cells in the bladder walls may have resulted in the formation of large porous spaces seen by scanning electron microscopy of the injured areas. The expression of nineteen growth-related mRNAs, including secreted phosphoprotein 1, inhibin beta-A, glial cell line-derived neurotrophic factor, and transforming growth factor beta 1, were significantly upregulated in the injured urinary bladders. In conclusion, the microenvironment in freeze-injured urinary bladders enables successful tissue engineering.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1937-3341
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12306003
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/19397471
関連名称
関連名称 19397471
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1089/ten.tea.2009.0038
関連名称
関連名称 10.1089/ten.tea.2009.0038
権利
権利情報 This is a copy of an article published in the TISSUE ENGINEERING PART A. Copyright© 2009 Mary Ann Liebert, Inc.; TISSUE ENGINEERING PART A is available online at: http://online.liebertpub.com.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000271746800015
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