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Implantation of Autologous Bone-Marrow-Derived Cells Reconstructs Functional Urethral Sphincters in Rabbits
http://hdl.handle.net/10091/15978
http://hdl.handle.net/10091/15978c57dae10-629b-4777-ae8e-8fe1cfe57178
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
TEA 2011 17 1069.pdf (2.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2012-09-21 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Implantation of Autologous Bone-Marrow-Derived Cells Reconstructs Functional Urethral Sphincters in Rabbits | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| DOI | ||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1089/ten.tea.2010.0478 | |||||||||||||||||||
| 関連名称 | 10.1089/ten.tea.2010.0478 | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||
| 著者 |
Imamura, Tetsuya
× Imamura, Tetsuya
× Ishizuka, Osamu
× Kinebuchi, Yoshiaki
× Kurizaki, Yoshiki
× Nakayama, Tsuyoshi
× Ishikawa, Masakuni
× Nishizawa, Osamu
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||||
| 氏名 | Imamura, Tetsuya | |||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ypACOmyC.html | |||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||
| 氏名 | Nishizawa, Osamu | |||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html | |||||||||||||||||||
| 出版者 | ||||||||||||||||||||
| 出版者 | MARY ANN LIEBERT INC | |||||||||||||||||||
| 引用 | ||||||||||||||||||||
| 内容記述 | TISSUE ENGINEERING PART A. 17(41098):1069-1081 (2011) | |||||||||||||||||||
| 書誌情報 |
TISSUE ENGINEERING PART A 巻 17, 号 7-8, p. 1069-1081, 発行日 2011-04 |
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| 抄録 | ||||||||||||||||||||
| 内容記述 | The purpose of this study was to determine if implantation of autologous bone-marrow-derived cells has the potential to treat stress urinary incontinence caused by intrinsic sphincter deficiency. Bone marrow cells harvested from femurs of New Zealand White rabbits were cultured for 10 days. Seven days before implantation, the urethral sphincters located at the internal urethral orifice were cryo-injured by spraying liquid nitrogen for 15 s. The cultured autologous bone-marrow-derived cells were implanted 7 days after cryo-injury. For controls, cell-free solutions were injected. At 7 and 14 days after implantation, leak point pressures were determined and the urethral sphincters were examined by immunohistochemistry. At 7 and 14 days, the cell-implanted regions contained numerous striated and smooth muscle-like cells expressing myoglobin and smooth muscle actin, respectively. The proportions of myoglobin- and smooth muscle actin-expressing areas in both the 7- and 14-day cell-implanted regions were significantly higher than in controls. By 14 days, these differentiated cells formed contacts with similar cells, creating layered muscle structures. At that time, the leak point pressure of the cell-implanted rabbits was significantly higher than that of the controls. In conclusion, autologous bone-marrow-derived cells can reconstruct functional urethral sphincters. | |||||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||||
| ISSN | ||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||
| 収録物識別子 | 1937-3341 | |||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA12306003 | |||||||||||||||||||
| PubMed | ||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/21091339 | |||||||||||||||||||
| 関連名称 | 21091339 | |||||||||||||||||||
| 権利 | ||||||||||||||||||||
| 権利情報 | This is a copy of an article published in the TISSUE ENGINEERING PART A. Copyright© 2011 Mary Ann Liebert, Inc.; TISSUE ENGINEERING PART A is available online at: http://online.liebertpub.com. | |||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
| WoS | ||||||||||||||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000288853300017 | |||||||||||||||||||
