{"_buckets": {"deposit": "127c26f4-0c8a-46e3-bfe0-2f2ff0a546e8"}, "_deposit": {"id": "3844", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3844"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003844", "sets": ["462"]}, "author_link": ["7458", "7459", "7460", "7461", "7462", "7463", "7464", "7465", "7466"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicVolumeNumber": "6", "bibliographic_titles": [{"bibliographic_title": "PLOS PATHOGENS"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Amyloidosis describes a group of protein folding diseases in which amyloid proteins are abnormally deposited in organs and/or tissues as fine fibrils. Mouse senile amyloidosis is a disorder in which apolipoprotein A-II (apoA-II) deposits as amyloid fibrils (AApoAII) and can be transmitted from one animal to another both by the feces and milk excreted by mice with amyloidosis. Thus, mouse AApoAII amyloidosis has been demonstrated to be a \"transmissible disease\". In this study, to further characterize the transmissibility of amyloidosis, AApoAII amyloid fibrils were injected into transgenic Apoa2(c)Tg(+/-) and normal R1.P1-Apoa2(c) mice to induce AApoAII systemic amyloidosis. Two months later, AApoAII amyloid deposits were found in the skeletal muscles of amyloid-affected mice, primarily in the blood vessels and in the interstitial tissues surrounding muscle fibers. When amyloid fibrils extracted from the skeletal muscles were subjected to Western blot analysis, apoA-II was detected. Amyloid fibril fractions isolated from the muscles not only demonstrated the structure of amyloid fibrils but could also induce amyloidosis in young mice depending on its fibril conformation. 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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1553-7366", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1553-7366", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12072310", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "APOLIPOPROTEIN-A-II; PATHOLOGICAL PRION PROTEIN; CREUTZFELDT-JAKOB-DISEASE; SENESCENCE-ACCELERATED MOUSE; INCLUSION-BODY MYOSITIS; AAPOAII AMYLOIDOSIS; PRPSC ACCUMULATION; TRANSGENIC MICE; INBRED STRAINS; APOA-II"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Amyloidosis describes a group of protein folding diseases in which amyloid proteins are abnormally deposited in organs and/or tissues as fine fibrils. Mouse senile amyloidosis is a disorder in which apolipoprotein A-II (apoA-II) deposits as amyloid fibrils (AApoAII) and can be transmitted from one animal to another both by the feces and milk excreted by mice with amyloidosis. Thus, mouse AApoAII amyloidosis has been demonstrated to be a \"transmissible disease\". In this study, to further characterize the transmissibility of amyloidosis, AApoAII amyloid fibrils were injected into transgenic Apoa2(c)Tg(+/-) and normal R1.P1-Apoa2(c) mice to induce AApoAII systemic amyloidosis. Two months later, AApoAII amyloid deposits were found in the skeletal muscles of amyloid-affected mice, primarily in the blood vessels and in the interstitial tissues surrounding muscle fibers. When amyloid fibrils extracted from the skeletal muscles were subjected to Western blot analysis, apoA-II was detected. Amyloid fibril fractions isolated from the muscles not only demonstrated the structure of amyloid fibrils but could also induce amyloidosis in young mice depending on its fibril conformation. These findings present a possible pathogenesis of amyloidosis: transmission of amyloid fibril conformation through muscle, and shed new light on the etiology involved in amyloid disorders."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Qian,  Jinze", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7458", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yan,  Jingmin", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7459", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ge,  Fengxia", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7460", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang,  Beiru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7461", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fu,  Xiaoying", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7462", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tomozawa,  Hiroshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7463", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sawashita,  Jinko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7464", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mori,  Masayuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7465", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi,  Keiichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7466", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Mouse_Senile_Amyloid_Fibrils_Deposited.pdf", "filesize": [{"value": "2.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 2800000.0, "url": {"label": "Mouse_Senile_Amyloid_Fibrils_Deposited.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3844/files/Mouse_Senile_Amyloid_Fibrils_Deposited.pdf"}, "version_id": "34ef82fa-22d3-4869-ac6f-b33d64ab3025"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "APOLIPOPROTEIN-A-II", "subitem_subject_scheme": "Other"}, {"subitem_subject": "PATHOLOGICAL PRION PROTEIN", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CREUTZFELDT-JAKOB-DISEASE", "subitem_subject_scheme": "Other"}, {"subitem_subject": "SENESCENCE-ACCELERATED MOUSE", "subitem_subject_scheme": "Other"}, {"subitem_subject": "INCLUSION-BODY MYOSITIS", "subitem_subject_scheme": "Other"}, {"subitem_subject": "AAPOAII AMYLOIDOSIS", "subitem_subject_scheme": "Other"}, {"subitem_subject": "PRPSC ACCUMULATION", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TRANSGENIC MICE", "subitem_subject_scheme": "Other"}, {"subitem_subject": "INBRED STRAINS", "subitem_subject_scheme": "Other"}, {"subitem_subject": "APOA-II", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Mouse Senile Amyloid Fibrils Deposited in Skeletal Muscle Exhibit Amyloidosis-Enhancing Activity", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Mouse Senile Amyloid Fibrils Deposited in Skeletal Muscle Exhibit Amyloidosis-Enhancing Activity", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/15958", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2012-09-11"}, "publish_date": "2012-09-11", "publish_status": "0", "recid": "3844", "relation": {}, "relation_version_is_last": true, "title": ["Mouse Senile Amyloid Fibrils Deposited in Skeletal Muscle Exhibit Amyloidosis-Enhancing Activity"], "weko_shared_id": -1}