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A Novel Immunoglobulin-Immunoglobulin Interaction in Autoimmunity
http://hdl.handle.net/10091/11106
http://hdl.handle.net/10091/111061a0f0eb8-261c-4ae6-a2bd-9ef7949d09d6
名前 / ファイル | ライセンス | アクション |
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Novel_Immunoglobulin-Immunoglobulin_Interaction.pdf (318.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-01-19 | |||||
タイトル | ||||||
タイトル | A Novel Immunoglobulin-Immunoglobulin Interaction in Autoimmunity | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1371/journal.pone.0001637 | |||||
関連名称 | 10.1371/journal.pone.0001637 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kawa, Shigeyuki
× Kawa, Shigeyuki× Kitahara, Kei× Hamano, Hideaki× Ozaki, Yayoi× Arakura, Norikazu× Yoshizawa, Kaname× Umemura, Takeji× Ota, Masao× Mizoguchi, Sadaaki× Shimozuru, Yasunori× Bahram, Seiamak |
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信州大学研究者総覧へのリンク | ||||||
表示名 | Kawa, Shigeyuki | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakeOVkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
表示名 | Umemura, Takeji | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
表示名 | Ota, Masao | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html | |||||
出版者 | ||||||
出版者 | PUBLIC LIBRARY SCIENCE | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PLOS ONE. 3(2):e1637 (2008) | |||||
書誌情報 |
PLOS ONE 巻 3, 号 2, 発行日 2008-02 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Well over six decades since its first description, the Rheumatoid Factor (RF)-autoantibodies recognizing Fc (constant) portion of IgG through their own Fab (antigen binding variable segments)-is believed to have come of age. Autoimmune pancreatitis is a unique form of pancreatitis, biologically characterized by an elevated serum IgG4 concentration. Given the fact that IgG4 myeloma proteins can act as RF, we initially hypothesized that IgG4 in autoimmune pancreatitis might do likewise, hence potentially contributing to disease pathogenesis. Indeed Western blotting clearly showed that IgG4 binds to IgG1 kappa, IgG2 kappa, IgG3 kappa myeloma proteins, as well as to IgG Fc, in line with a typical RF activity. Further experiments however unraveled the unexpected fact that unlike hitherto known RF, IgG4 does not engage IgG Fc through its Fab, but its very own Fc. These data therefore collectively describe a Novel RF (NRF) in autoimmune pancreatitis. In the future, the relevance of NRF, beyond autoimmune pancreatitis, in both diagnosis/prognosis as well as pathophysiology of autoimmune and other systemic diseases where IgG4's role seems paramount, needs to be systematically assessed. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1932-6203 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/18297131 | |||||
関連名称 | 18297131 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2008 Kawa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000260586400030 |