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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

A Novel Heterophilic Antibody Interaction Involves IgG4

http://hdl.handle.net/10091/11105
e7234328-d5ac-405b-83e7-ad91e7631466
名前 / ファイル ライセンス アクション
Novel_heterophilic_antibody_interaction.pdf Novel_heterophilic_antibody_interaction.pdf (380.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2011-01-19
タイトル
言語 en
タイトル A Novel Heterophilic Antibody Interaction Involves IgG4
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Ito, T

× Ito, T

WEKO 7596

en Ito, T

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Kitahara, K

× Kitahara, K

WEKO 7597

en Kitahara, K

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Umemura, T

× Umemura, T

WEKO 7598

en Umemura, T

Search repository
Ota, M

× Ota, M

WEKO 7599

en Ota, M

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Shimozuru, Y

× Shimozuru, Y

WEKO 7600

en Shimozuru, Y

Search repository
Kawa, S

× Kawa, S

WEKO 7601

en Kawa, S

Search repository
Bahram, S

× Bahram, S

WEKO 7602

en Bahram, S

Search repository
信州大学研究者総覧へのリンク
氏名 Umemura, T
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html
信州大学研究者総覧へのリンク
氏名 Ota, M
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html
信州大学研究者総覧へのリンク
氏名 Kawa, S
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakeOVkh.html
出版者
出版者 WILEY-BLACKWELL PUBLISHING, INC
引用
内容記述タイプ Other
内容記述 SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 71(2):109-114 (2010)
書誌情報 SCANDINAVIAN JOURNAL OF IMMUNOLOGY

巻 71, 号 2, p. 109-114, 発行日 2010-02
抄録
内容記述タイプ Abstract
内容記述 IgG4 has been implicated in a diverse set of complex pathologies - e.g. autoimmune pancreatitis (AIP), idiopathic membranous nephropathy - and carries unique features including lack of activation of the classical complement pathway and a dynamic Fab-arm exchange. We recently showed that the rheumatoid factor (RF)-like activity of IgG4 is achieved through a hitherto unknown, Fc-Fc (and not Fab-Fc as is the case in classical RF; CRF) interaction; hence the name, novel RF (NRF). Here, we further explore the resemblance/difference between CRF and NRF. As heterophilic interactions of human IgM RF (CRF) are well known, we checked whether this is the case for IgG4. Human IgG4 showed variable reactivity to animal IgGs: reacting intensely with rabbit and mouse IgGs, but weakly with others. The binding to rabbit IgG was not through the Fab (as in CRF) but via the Fc piece, as was recently shown for human IgG (NRF). This binding correlates with the IgG4 concentration per se and could therefore be of diagnostic usage and incidentally explain some observed interferences in biological assays. In conclusion, here is defined a novel heterophilic antibody interaction and is established the universality of the unique Fc-Fc binding, both involving IgG4.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0300-9475
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00833566
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/20384862
関連名称
関連名称 20384862
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/j.1365-3083.2009.02353.x
関連名称
関連名称 10.1111/j.1365-3083.2009.02353.x
権利
権利情報 The definitive version is available at www.blackwell-synergy.com
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000273688300006
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