ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "dbd1104e-c518-43df-ba07-0bd461ff0228"}, "_deposit": {"id": "3866", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3866"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003866", "sets": ["462"]}, "author_link": ["7637", "7638", "7639", "7640", "7641", "7642", "7643", "7644"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "553", "bibliographicPageStart": "548", "bibliographicVolumeNumber": "41", "bibliographic_titles": [{"bibliographic_title": "HORMONE AND METABOLIC RESEARCH"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "μ-Crystallin is an NADPH-dependent cytosolic T3-binding protein. A knockout study in mice showed that μ-crystallin has a physiological function as a reservoir of T3 in the cytoplasm in vivo. Patients with nonsyndromic deafness were reported to have point mutations in the μ-crystallin gene. The expression of μ-crystallin is regulated by multiple factors. The present study was performed to determine whether thyroid function is related to the expression of μ-crystallin mRNA in peripheral mononuclear cells. We examined 23 normal healthy male and female subjects and 15 patients with Graves\u0027 disease. μ-Crystallin protein expression was determined immunohistochemically in peripheral mononuclear cells. The expression of μ-crystallin mRNA was assessed by reverse transcription of total RNA from peripheral mononuclear cells followed by quantitative PCR. μ-Crystallin protein was detected in peripheral mononuclear cells. The mRNA expression was negatively correlated with age in normal female subjects. The values in female subjects were significantly higher than those in males. The values were positively correlated with serum TSH concentration. The values of the thyrotoxic patients with Graves\u0027 disease were lower than those in healthy subjects. A transient increase in μ-crystallin expression was observed within 14-42 days after the initial treatment with antithyroid medication. Thyroid hormone inversely relates to the expression of μ-crystallin mRNA in euthyroid mononuclear cells. Abrupt suppression of thyroid function leads to overexpression of μ-crystallin mRNA in thyrotoxic mononuclear cells. Thyroid hormone-regulated μ-crystallin expression may control thyroid hormone action via the intracytoplasmic T? capacity.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ(コンテンツの種類)", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット:mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "HORMONE AND METABOLIC RESEARCH. 41(7):548-553 (2009)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Yamazaki, M", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.WUTFHVkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000268640200007"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "GEORG THIEME VERLAG KG"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "19280551"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/19280551", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1055/s-0029-1202865"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1055/s-0029-1202865", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright (c) Georg Thieme Verlag KG Stuttgart ・ New York"}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0018-5043", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0018-5043", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00665337", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "CRYM; thyroid hormone; thyroid hormone binding protein; mu-crystallin; hyperthyroidism"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "PROTEIN P38CTBP; BINDING-PROTEIN; CRYM; DELETION; DEAFNESS; COCHLEA; CELLS; GENE"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "mu-Crystallin is an NADPH-dependent cytosolic T3-binding protein. A knockout study in mice showed that mu-crystallin has a physiological function as a reservoir of T3 in the cytoplasm in vivo. Patients with nonsyndromic deafness were reported to have point mutations in the mu-crystallin gene. The expression of mu-crystallin is regulated by multiple factors. The present study was performed to determine whether thyroid function is related to the expression of mu-crystallin mRNA in peripheral mononuclear cells. We examined 23 normal healthy male and female subjects and 15 patients with Graves\u0027 disease. mu-Crystallin protein expression was determined immunohistochemically in peripheral mononuclear cells. The expression of mu-crystallin mRNA was assessed by reverse transcription of total RNA from peripheral mononuclear cells followed by quantitative PCR. mu-Crystallin protein was detected in peripheral mononuclear cells. The mRNA expression was negatively correlated with age in normal female subjects. The values in female subjects were significantly higher than those in males. The values were positively correlated with serum TSH concentration. The values of the thyrotoxic patients with Graves\u0027 disease were lower than those in healthy subjects. A transient increase in mu-crystallin expression was observed within 14-42 days after the initial treatment with antithyroid medication. Thyroid hormone inversely relates to the expression of mu-crystallin mRNA in euthyroid mononuclear cells. Abrupt suppression of thyroid function leads to overexpression of mu-crystallin mRNA in thyrotoxic mononuclear cells. Thyroid hormone-regulated mu-crystallin expression may control thyroid hormone action via the intracytoplasmic T3 capacity."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Suzuki,  S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7637", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takei,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7638", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishio,  S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7639", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inaba,  H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7640", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sato,  A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7641", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamazaki,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7642", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shinomiya,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7643", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashizume,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7644", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Spiking_expression_mu-Crystallin_mRNA.pdf", "filesize": [{"value": "568.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 568500.0, "url": {"label": "Spiking_expression_mu-Crystallin_mRNA.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3866/files/Spiking_expression_mu-Crystallin_mRNA.pdf"}, "version_id": "851987de-02eb-4913-8c9f-9d00306b0177"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "CRYM", "subitem_subject_scheme": "Other"}, {"subitem_subject": "thyroid hormone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "thyroid hormone binding protein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mu-crystallin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "hyperthyroidism", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Spiking Expression of μ-Crystallin mRNA during Treatment with Methimazole in Patients with Graves\u0027 Hyperthyroidism", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Spiking Expression of μ-Crystallin mRNA during Treatment with Methimazole in Patients with Graves\u0027 Hyperthyroidism", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/11101", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2011-01-19"}, "publish_date": "2011-01-19", "publish_status": "0", "recid": "3866", "relation": {}, "relation_version_is_last": true, "title": ["Spiking Expression of μ-Crystallin mRNA during Treatment with Methimazole in Patients with Graves\u0027 Hyperthyroidism"], "weko_shared_id": -1}
  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Spiking Expression of μ-Crystallin mRNA during Treatment with Methimazole in Patients with Graves' Hyperthyroidism

http://hdl.handle.net/10091/11101
http://hdl.handle.net/10091/11101
5301d3d8-4f3d-4250-bce5-079f34f79f55
名前 / ファイル ライセンス アクション
Spiking_expression_mu-Crystallin_mRNA.pdf Spiking_expression_mu-Crystallin_mRNA.pdf (568.5 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2011-01-19
タイトル
言語 en
タイトル Spiking Expression of μ-Crystallin mRNA during Treatment with Methimazole in Patients with Graves' Hyperthyroidism
言語
言語 eng
キーワード
主題Scheme Other
主題 CRYM
キーワード
主題Scheme Other
主題 thyroid hormone
キーワード
主題Scheme Other
主題 thyroid hormone binding protein
キーワード
主題Scheme Other
主題 mu-crystallin
キーワード
主題Scheme Other
主題 hyperthyroidism
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Suzuki, S

× Suzuki, S

WEKO 7637

en Suzuki, S

Search repository
Takei, M

× Takei, M

WEKO 7638

en Takei, M

Search repository
Nishio, S

× Nishio, S

WEKO 7639

en Nishio, S

Search repository
Inaba, H

× Inaba, H

WEKO 7640

en Inaba, H

Search repository
Sato, A

× Sato, A

WEKO 7641

en Sato, A

Search repository
Yamazaki, M

× Yamazaki, M

WEKO 7642

en Yamazaki, M

Search repository
Shinomiya, K

× Shinomiya, K

WEKO 7643

en Shinomiya, K

Search repository
Hashizume, K

× Hashizume, K

WEKO 7644

en Hashizume, K

Search repository
信州大学研究者総覧へのリンク
氏名 Yamazaki, M
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WUTFHVkh.html
出版者
出版者 GEORG THIEME VERLAG KG
引用
内容記述タイプ Other
内容記述 HORMONE AND METABOLIC RESEARCH. 41(7):548-553 (2009)
書誌情報 HORMONE AND METABOLIC RESEARCH

巻 41, 号 7, p. 548-553, 発行日 2009-07
抄録
内容記述タイプ Abstract
内容記述 μ-Crystallin is an NADPH-dependent cytosolic T3-binding protein. A knockout study in mice showed that μ-crystallin has a physiological function as a reservoir of T3 in the cytoplasm in vivo. Patients with nonsyndromic deafness were reported to have point mutations in the μ-crystallin gene. The expression of μ-crystallin is regulated by multiple factors. The present study was performed to determine whether thyroid function is related to the expression of μ-crystallin mRNA in peripheral mononuclear cells. We examined 23 normal healthy male and female subjects and 15 patients with Graves' disease. μ-Crystallin protein expression was determined immunohistochemically in peripheral mononuclear cells. The expression of μ-crystallin mRNA was assessed by reverse transcription of total RNA from peripheral mononuclear cells followed by quantitative PCR. μ-Crystallin protein was detected in peripheral mononuclear cells. The mRNA expression was negatively correlated with age in normal female subjects. The values in female subjects were significantly higher than those in males. The values were positively correlated with serum TSH concentration. The values of the thyrotoxic patients with Graves' disease were lower than those in healthy subjects. A transient increase in μ-crystallin expression was observed within 14-42 days after the initial treatment with antithyroid medication. Thyroid hormone inversely relates to the expression of μ-crystallin mRNA in euthyroid mononuclear cells. Abrupt suppression of thyroid function leads to overexpression of μ-crystallin mRNA in thyrotoxic mononuclear cells. Thyroid hormone-regulated μ-crystallin expression may control thyroid hormone action via the intracytoplasmic T? capacity.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0018-5043
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00665337
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/19280551
関連名称 19280551
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1055/s-0029-1202865
関連名称 10.1055/s-0029-1202865
権利
権利情報 Copyright (c) Georg Thieme Verlag KG Stuttgart ・ New York
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000268640200007
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 14:16:05.963695
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3