WEKO3
-
RootNode
アイテム
Exogenous surfactant instillation attenuates inflammatory response to acid-induced lung injury in rat
http://hdl.handle.net/10091/11095
http://hdl.handle.net/10091/11095fcb25882-492b-4f8c-9634-282454b51118
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Exogenous_surfactant_instillation_attenuates_inflammatory.pdf (474.2 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2011-01-17 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Exogenous surfactant instillation attenuates inflammatory response to acid-induced lung injury in rat | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.pupt.2009.10.004 | |||||||||||||||||
| 関連名称 | 10.1016/j.pupt.2009.10.004 | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Cytokine-induced neutrophil chemoattractant, Bronchoalveolar lavage fluid, Acute lung injury, Pulmonary edema | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| タイプ | journal article | |||||||||||||||||
| 著者 |
Jian, Ming-Yuan
× Jian, Ming-Yuan
× Koizumi, Tomonobu
× Tsushima, Kenji
× Yokoyama, Toshiki
× Kubo, Keishi
× Baba, Atsushi
|
|||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||
| 氏名 | Koizumi, Tomonobu | |||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WakmHhkh.html | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | |||||||||||||||||
| 引用 | ||||||||||||||||||
| 内容記述 | PULMONARY PHARMACOLOGY & THERAPEUTICS. 23(1):43-47 (2010) | |||||||||||||||||
| 書誌情報 |
PULMONARY PHARMACOLOGY & THERAPEUTICS 巻 23, 号 1, p. 43-47, 発行日 2010-10 |
|||||||||||||||||
| 抄録 | ||||||||||||||||||
| 内容記述 | The present study was performed to investigate the role of exogenous surfactant on hydrochloric acid (HCL) - induced lung injury in rats. Six-week-old male Sprague-Dawley rats were anesthetized by intraperitoneal injection of pentobarbital sodium (40 mg/kg) and HCL (0.1 N, 2 mL/kg) or normal saline (NS, 2 mL/kg) was instilled into the trachea. Thirty minutes after HCL instillation, surfactant at a dose of 60 mg (=2 mL)/body or NS (2 mL) was instilled into the rat lungs. Animals in another experimental group were also treated with the same dose of surfactant supplement 2 hours after the first administration. Bronchoalveolar lavage fluid (BALF) was obtained 5 hours after HCL instillation. In BALF, increases in total nuclear cell counts, neutrophil counts, optical density at 412 nm as an indicator Of Pulmonary hemorrhage, neutrophil elastase activity, concentrations of albumin and cytokine-induced neutrophil chemoattractant (CINC) induced by HCL instillation were significantly attenuated by surfactant treatment. The wet-to-dry weight (W/D) ratio in the lung and partial oxygen tension (P-O2) were also estimated; surfactant treatment significantly attenuated the W/D ratio and improved deteriorated P-O2 induced by HCL Additional surfactant supplementation did not show further beneficial effects on HCL-induced lung injury compared with a single treatment. These results suggest that surfactant shows an anti-inflammatory effect on acid lung injury in rats but the beneficial effects may be dose limited. | |||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||
| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||
| 収録物識別子 | 1094-5539 | |||||||||||||||||
| 書誌レコードID | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA1115999X | |||||||||||||||||
| PubMed | ||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/19835974 | |||||||||||||||||
| 関連名称 | 19835974 | |||||||||||||||||
| 権利 | ||||||||||||||||||
| 権利情報 | Copyright (c) 2010 Elsevier Ltd. | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
| WoS | ||||||||||||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000274968400007 | |||||||||||||||||
Share
Cite as
Jian, Ming-Yuan, Koizumi, Tomonobu, Tsushima, Kenji, Yokoyama, Toshiki, Kubo, Keishi, Baba, Atsushi, 2010, Exogenous surfactant instillation attenuates inflammatory response to acid-induced lung injury in rat: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 43–47 p.
Loading...
