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Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats
http://hdl.handle.net/10091/11094
http://hdl.handle.net/10091/1109478151bb3-7e1b-46fe-b813-635e3a86fea1
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-01-17 | |||||
タイトル | ||||||
タイトル | Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
関連識別子 | https://doi.org/10.1016/j.ejphar.2010.05.039 | |||||
関連名称 | 10.1016/j.ejphar.2010.05.039 | |||||
キーワード | ||||||
主題 | Hydrochloric acid, Acute lung injury, Acute respiratory distress syndrome, Neutrophil elastase, Protease inhibitor, Neutrophil | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yoshikawa, Sumiko
× Yoshikawa, Sumiko× Tsushima, Kenji× Koizumi, Tomonobu× Kubo, Keishi |
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信州大学研究者総覧へのリンク | ||||||
表示名 | Koizumi, Tomonobu | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WakmHhkh.html | |||||
出版者 | ||||||
出版者 | ELSEVIER SCIENCE BV | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | EUROPEAN JOURNAL OF PHARMACOLOGY. 641(2-3):220-225 (2010) | |||||
書誌情報 |
EUROPEAN JOURNAL OF PHARMACOLOGY 巻 641, 号 2-3, p. 220-225, ページ数 2-3, 発行日 2010-09 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The present study was designed to examine the combined effects of a synthetic protease inhibitor, gabexate mesilate, with a specific neutrophil elastase inhibitor, sivelestat sodium, on acid-induced lung injury. Adult male Sprague-Dawley rats weighing 300-350 g were anaesthetised intraperitoneally with pentobarbitone sodium and the right jugular vein was cannulated. Following tracheostomy, rats were ventilated mechanically and underwent intratracheal instillation of hydrochloric acid (HCl, 0.1 N 1.5 ml/kg) or normal saline. Gabexate mesilate (10 mg/kg, i.p.) and/or sivelestat sodium (10 mg/kg/h, i.v.) were administered 30 min before HCl instillation. Bronchoalveolar lavage fluid samples were obtained 5 h after HCl instillation. in bronchoalveolar lavage fluid, the HCl-induced increases in total nucleated cell counts, neutrophil counts, optical density at 412 nm as an index of pulmonary haemorrhage, concentrations of albumin and cytokine-induced neutrophil chemoattractant (CINC) were significantly attenuated by either gabexate mesilate or sivelestat sodium treatment. Gabexate mesilate or sivelestat sodium treatment also significantly attenuated the wet to dry weight ratio induced by HCl. However, combined treatment with both gabexate mesilate and sivelestat sodium did not show additive effects on HO-induced lung injury, compared with single treatments. These findings suggested that gabexate mesilate and sivelestat sodium each exhibited protective effects on acid-induced lung injury, but that synergistic effects of both agents are limited in this acid-induced lung injury model. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0014-2999 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00639687 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/20542026 | |||||
関連名称 | 20542026 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2010 Elsevier B.V. | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000279905500022 |