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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Polyclonality of BRAF Mutations in Acquired Melanocytic Nevi

http://hdl.handle.net/10091/11090
http://hdl.handle.net/10091/11090
58a4fae1-a5a1-4505-aeb5-ecff1e914eb5
名前 / ファイル ライセンス アクション
Polyclonality_BRAF_mutations_Acquired_Melanocytic_Nevi.pdf Polyclonality_BRAF_mutations_Acquired_Melanocytic_Nevi.pdf (750.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2011-01-17
タイトル
タイトル Polyclonality of BRAF Mutations in Acquired Melanocytic Nevi
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1093/jnci/djp309
関連名称 10.1093/jnci/djp309
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Lin, Jingrong

× Lin, Jingrong

en Lin, Jingrong

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Takata, Minoru

× Takata, Minoru

en Takata, Minoru

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Murata, Hiroshi

× Murata, Hiroshi

en Murata, Hiroshi

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Goto, Yasufumi

× Goto, Yasufumi

en Goto, Yasufumi

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Kido, Kenji

× Kido, Kenji

en Kido, Kenji

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Ferrone, Soldano

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en Ferrone, Soldano

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Saida, Toshiaki

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en Saida, Toshiaki

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出版者
出版者 OXFORD UNIV PRESS INC
引用
内容記述 JOURNAL OF THE NATIONAL CANCER INSTITUTE. 101(20):1423-1427 (2009)
書誌情報 JOURNAL OF THE NATIONAL CANCER INSTITUTE

巻 101, 号 20, p. 1423-1427, 発行日 2009-10-21
抄録
内容記述 Melanocytic nevi are thought to be senescent clones of melanocytes that have acquired an oncogenic BRAF mutation. BRAF mutation is considered to be a crucial step in the initiation of melanocyte transformation. However, using immunomagnetic separation or laser-capture microdissection, we examined BRAF mutations in sets of approximately 50 single cells isolated from acquired melanocytic nevi from 13 patients and found a substantial number of nevus cells that contained wild-type BRAF mixed with nevus cells that contained BRAF(V600E). Furthermore, we simultaneously amplified BRAF exon 15 and a neighboring single nucleotide polymorphism (SNP), rs7801086, from nevus cell samples obtained from four patients who were heterozygous for this SNP. Subcloning and sequencing of the polymerase chain reaction products showed that both SNP alleles harbored the BRAF(V600E) mutation, indicating that the same BRAF(V600E) mutation originated from different cells. The polyclonality of BRAF mutations in acquired melanocytic nevi suggests that mutation of BRAF may not be an initial event in melanocyte transformation.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 0027-8874
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00702998
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/19752400
関連名称 19752400
権利
権利情報 Copyright (c) The Author 2009. Published by Oxford University Press.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000271108300011
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