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Patients and Methods Subjects comprised 95 stable COPD patients, 52 never-smoker asthma patients and 29 healthy never-smokers \u003e 60 years old, all matched for age, in whom respiratory impedance was examined by IOS. Results In both asthma and COPD patients, a significant increase in respiratory resistance (Rrs5) and more negative value of respiratory reactance (Xrs5) at 5 Hz of oscillatory frequency with an increase in resonant frequency (fres) were observed when compared with healthy never-smokers. In asthma, a significant increase in respiratory resistance at 20 Hz (Rrs20) was also observed when compared with healthy never-smokers and COPD. The increases in Rrs5 and relative changes of Xrs5 to more negative were remarkable with increasing severity of COPD. On the other hand, among patients with asthma, these changes in Rrs5 and Xrs5 were also observed in asthmatics with normal FEV1/FVC. 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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Evaluation of Respiratory Impedance in Asthma and COPD by an Impulse Oscillation System

http://hdl.handle.net/10091/11076
http://hdl.handle.net/10091/11076
eb6d8147-df5c-4d04-af82-8400f61a7eca
名前 / ファイル ライセンス アクション
Evaluation_Respiratory_Impedance_Asthma_COPD.pdf Evaluation_Respiratory_Impedance_Asthma_COPD.pdf (390.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2011-01-13
タイトル
言語 en
タイトル Evaluation of Respiratory Impedance in Asthma and COPD by an Impulse Oscillation System
言語
言語 eng
キーワード
主題Scheme Other
主題 asthma
キーワード
主題Scheme Other
主題 COPD
キーワード
主題Scheme Other
主題 impulse oscillometry
キーワード
主題Scheme Other
主題 resistance
キーワード
主題Scheme Other
主題 reactance
キーワード
主題Scheme Other
主題 expiratory airflow obstruction
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Kanda, Shintarou

× Kanda, Shintarou

WEKO 7782

en Kanda, Shintarou

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Fujimoto, Keisaku

× Fujimoto, Keisaku

WEKO 7783

en Fujimoto, Keisaku

Search repository
Komatsu, Yoshimichi

× Komatsu, Yoshimichi

WEKO 7784

en Komatsu, Yoshimichi

Search repository
Yasuo, Masanori

× Yasuo, Masanori

WEKO 7785

en Yasuo, Masanori

Search repository
Hanaoka, Masayuki

× Hanaoka, Masayuki

WEKO 7786

en Hanaoka, Masayuki

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Kubo, Keishi

× Kubo, Keishi

WEKO 7787

en Kubo, Keishi

Search repository
信州大学研究者総覧へのリンク
氏名 Fujimoto, Keisaku
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.yFfaHFkh.html
信州大学研究者総覧へのリンク
氏名 Yasuo, Masanori
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ypnegpkh.html
信州大学研究者総覧へのリンク
氏名 Hanaoka, Masayuki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.yCLmHVkh.html
出版者
出版者 JAPAN SOC INTERNAL MEDICINE
引用
内容記述タイプ Other
内容記述 INTERNAL MEDICINE. 49(1):23-30 (2010)
書誌情報 INTERNAL MEDICINE

巻 49, 号 1, p. 23-30, 発行日 2010-01
抄録
内容記述タイプ Abstract
内容記述 Objective The purpose of this study was to clarify the differences in physiological properties of the airways between asthma and COPD using an impulse oscillation system (IOS). Patients and Methods Subjects comprised 95 stable COPD patients, 52 never-smoker asthma patients and 29 healthy never-smokers > 60 years old, all matched for age, in whom respiratory impedance was examined by IOS. Results In both asthma and COPD patients, a significant increase in respiratory resistance (Rrs5) and more negative value of respiratory reactance (Xrs5) at 5 Hz of oscillatory frequency with an increase in resonant frequency (fres) were observed when compared with healthy never-smokers. In asthma, a significant increase in respiratory resistance at 20 Hz (Rrs20) was also observed when compared with healthy never-smokers and COPD. The increases in Rrs5 and relative changes of Xrs5 to more negative were remarkable with increasing severity of COPD. On the other hand, among patients with asthma, these changes in Rrs5 and Xrs5 were also observed in asthmatics with normal FEV1/FVC. Interestingly, Xrs5 showed further changes to more negative in expiration of tidal breath in severe COPD, whereas no significant changes in Xrs5 to more negative in expiration was observed in healthy never-smokers and asthmatics with and without normal FEV1/FVC. Conclusion IOS may be useful for detecting pathophysiological changes of respiratory system in accordance with severity of COPD and even in asthmatics with normal FEV1/FVC. The larger within-breath changes of Xrs5 to more negative in severe COPD may represent easy collapsibility of small airways in expiration of tidal breath. These properties may help to analyze airway mechanics and to identify abnormalities of the airways that cannot be found by spirometry alone.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0918-2918
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10827774
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/20045997
関連名称 20045997
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.2169/internalmedicine.49.2191
関連名称 10.2169/internalmedicine.49.2191
権利
権利情報 Copyright (c) 2010 The Japanese Society of Internal Medicine
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000273363000004
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