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A2BP1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients
http://hdl.handle.net/10091/11072
http://hdl.handle.net/10091/110724435fc2f-5843-4636-b76c-37a54416daa3
| 名前 / ファイル | ライセンス | アクション |
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A2BP1_novel_susceptible_gene.pdf (405.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2011-01-12 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | A2BP1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| DOI | ||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.humimm.2010.02.009 | |||||||||||||||||
| 関連名称 | 10.1016/j.humimm.2010.02.009 | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | Primary biliary cirrhosis, Microsatellite, HLA, Ataxin 2-binding protein 1 gene | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| タイプ | journal article | |||||||||||||||||
| 著者 |
Joshita, Satoru
× Joshita, Satoru
× Umemura, Takeji
× Yoshizawa, Kaname
× Katsuyama, Yoshihiko
× Tanaka, Eiji
× Ota, Masao
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||
| 氏名 | Joshita, Satoru | |||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.PeLNbVym.html | |||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||
| 氏名 | Umemura, Takeji | |||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html | |||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||
| 氏名 | Tanaka, Eiji | |||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html | |||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||
| 氏名 | Ota, Masao | |||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | ELSEVIER SCIENCE INC | |||||||||||||||||
| 引用 | ||||||||||||||||||
| 内容記述 | HUMAN IMMUNOLOGY. 71(5):520-524 (2010) | |||||||||||||||||
| 書誌情報 |
HUMAN IMMUNOLOGY 巻 71, 号 5, p. 520-524, 発行日 2010-05 |
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| 抄録 | ||||||||||||||||||
| 内容記述 | Primary biliary cirrhosis (PBC) is a complex autoimmune liver disease with an etiology that remains to be conclusively elucidated. As such, we screened the human genome for genes that might influence PBC susceptibility or resistance using 400 microsatellite markers. A strong candidate gene indicated by susceptibility microsatellite markers was further evaluated by association analysis using single nucleotide polymorphisms (SNPs). A total of 126 patients with PBC and 95 healthy Japanese controls were enrolled. Four candidate susceptible regions and seven candidate protective regions were statistically associated with PBC. Because the D16S423 marker on chromosome 16p showed the strongest evidence of linkage, the protein-coding gene ataxin 2-binding protein 1 (A2BP1) lying 27 kb on the centromeric side of D16S423 was targeted as a candidate susceptible gene. Seven SNPs (rs17139207, rs12926282, rs17139244, rs6500742, rs4146812, rs4124065, and rs889699) in the A2BP1 gene were genotyped in patients and controls. The rs17139244 SNP was found to be weakly associated with PBC in an additive model. The genotype frequency of the major C allele at rs6500742 was significantly associated with PBC, compared with healthy controls. This study showed a total of 11 candidate PBC susceptibility or resistance regions. In particular, the A2BP1 gene might play a pivotal role for susceptibility to PBC. | |||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||
| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||
| 収録物識別子 | 0198-8859 | |||||||||||||||||
| 書誌レコードID | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA00214087 | |||||||||||||||||
| PubMed | ||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/20153395 | |||||||||||||||||
| 関連名称 | 20153395 | |||||||||||||||||
| 権利 | ||||||||||||||||||
| 権利情報 | Copyright (c) 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
| WoS | ||||||||||||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000277089300014 | |||||||||||||||||
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Joshita, Satoru, Umemura, Takeji, Yoshizawa, Kaname, Katsuyama, Yoshihiko, Tanaka, Eiji, Ota, Masao, 2010, A2BP1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients: ELSEVIER SCIENCE INC, 520–524 p.
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