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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

A2BP1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients

http://hdl.handle.net/10091/11072
http://hdl.handle.net/10091/11072
4435fc2f-5843-4636-b76c-37a54416daa3
名前 / ファイル ライセンス アクション
A2BP1_novel_susceptible_gene.pdf A2BP1_novel_susceptible_gene.pdf (405.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2011-01-12
タイトル
タイトル A2BP1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1016/j.humimm.2010.02.009
関連名称 10.1016/j.humimm.2010.02.009
キーワード
主題 Primary biliary cirrhosis, Microsatellite, HLA, Ataxin 2-binding protein 1 gene
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Joshita, Satoru

× Joshita, Satoru

en Joshita, Satoru

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Umemura, Takeji

× Umemura, Takeji

en Umemura, Takeji

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Yoshizawa, Kaname

× Yoshizawa, Kaname

en Yoshizawa, Kaname

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Katsuyama, Yoshihiko

× Katsuyama, Yoshihiko

en Katsuyama, Yoshihiko

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Tanaka, Eiji

× Tanaka, Eiji

en Tanaka, Eiji

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Ota, Masao

× Ota, Masao

en Ota, Masao

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信州大学研究者総覧へのリンク
氏名 Joshita, Satoru
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.PeLNbVym.html
信州大学研究者総覧へのリンク
氏名 Umemura, Takeji
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html
信州大学研究者総覧へのリンク
氏名 Tanaka, Eiji
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html
信州大学研究者総覧へのリンク
氏名 Ota, Masao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html
出版者
出版者 ELSEVIER SCIENCE INC
引用
内容記述 HUMAN IMMUNOLOGY. 71(5):520-524 (2010)
書誌情報 HUMAN IMMUNOLOGY

巻 71, 号 5, p. 520-524, 発行日 2010-05
抄録
内容記述 Primary biliary cirrhosis (PBC) is a complex autoimmune liver disease with an etiology that remains to be conclusively elucidated. As such, we screened the human genome for genes that might influence PBC susceptibility or resistance using 400 microsatellite markers. A strong candidate gene indicated by susceptibility microsatellite markers was further evaluated by association analysis using single nucleotide polymorphisms (SNPs). A total of 126 patients with PBC and 95 healthy Japanese controls were enrolled. Four candidate susceptible regions and seven candidate protective regions were statistically associated with PBC. Because the D16S423 marker on chromosome 16p showed the strongest evidence of linkage, the protein-coding gene ataxin 2-binding protein 1 (A2BP1) lying 27 kb on the centromeric side of D16S423 was targeted as a candidate susceptible gene. Seven SNPs (rs17139207, rs12926282, rs17139244, rs6500742, rs4146812, rs4124065, and rs889699) in the A2BP1 gene were genotyped in patients and controls. The rs17139244 SNP was found to be weakly associated with PBC in an additive model. The genotype frequency of the major C allele at rs6500742 was significantly associated with PBC, compared with healthy controls. This study showed a total of 11 candidate PBC susceptibility or resistance regions. In particular, the A2BP1 gene might play a pivotal role for susceptibility to PBC.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 0198-8859
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00214087
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/20153395
関連名称 20153395
権利
権利情報 Copyright (c) 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000277089300014
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Cite as

Joshita, Satoru, Umemura, Takeji, Yoshizawa, Kaname, Katsuyama, Yoshihiko, Tanaka, Eiji, Ota, Masao, 2010, A2BP1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients: ELSEVIER SCIENCE INC, 520–524 p.

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