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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Reactive Oxygen Generated by NADPH Oxidase 1 (Nox1) Contributes to Cell Invasion by Regulating Matrix Metalloprotease-9 Production and Cell Migration

http://hdl.handle.net/10091/11060
http://hdl.handle.net/10091/11060
566ef8ad-bbfc-4685-8bb4-091494e464a6
名前 / ファイル ライセンス アクション
Reactive_Oxygen_Generated_NADPH_Oxidase1.pdf Reactive_Oxygen_Generated_NADPH_Oxidase1.pdf (1.2 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2011-01-11
タイトル
タイトル Reactive Oxygen Generated by NADPH Oxidase 1 (Nox1) Contributes to Cell Invasion by Regulating Matrix Metalloprotease-9 Production and Cell Migration
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1074/jbc.M109.071779
関連名称 10.1074/jbc.M109.071779
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Shinohara, Masahiro

× Shinohara, Masahiro

en Shinohara, Masahiro

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Adachi, Yoshifumi

× Adachi, Yoshifumi

en Adachi, Yoshifumi

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Mitsushita, Junji

× Mitsushita, Junji

en Mitsushita, Junji

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Kuwabara, Mitsuhiro

× Kuwabara, Mitsuhiro

en Kuwabara, Mitsuhiro

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Nagasawa, Atsushi

× Nagasawa, Atsushi

en Nagasawa, Atsushi

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Harada, Saori

× Harada, Saori

en Harada, Saori

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Furuta, Shuichi

× Furuta, Shuichi

en Furuta, Shuichi

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Zhang, Yugen

× Zhang, Yugen

en Zhang, Yugen

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Seheli, Kajla

× Seheli, Kajla

en Seheli, Kajla

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Miyazaki, Hitoshi

× Miyazaki, Hitoshi

en Miyazaki, Hitoshi

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Kamata, Tohru

× Kamata, Tohru

en Kamata, Tohru

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出版者
出版者 AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
引用
内容記述 JOURNAL OF BIOLOGICAL CHEMISTRY. 285(7):4481-4488 (2010)
書誌情報 JOURNAL OF BIOLOGICAL CHEMISTRY

巻 285, 号 7, p. 4481-4488, 発行日 2010-02-12
内容記述
内容記述タイプ Other
内容記述 This research was originally published in J. Biol. Chem. Masahiro Shinohara, Yoshifumi Adachi, Junji Mitsushita, Mitsuhiro Kuwabara, Atsushi Nagasawa, Saori Harada, Shuichi Furuta, Yugen Zhang, Kajla Seheli, Hitoshi Miyazaki and Tohru Kamata. Enhancement of Reactive Oxygen Species Production and Chlamydial Infection by the Mitochondrial Nod-like Family Member NLRX1 . J. Biol. Chem. 2010 285: 41637-41645. Copyright (c) the American Society for Biochemistry and Molecular Biology
抄録
内容記述 A mediating role of the reactive oxygen species-generating enzyme Nox1 has been suggested for Ras oncogene transformation phenotypes including anchorage-independent cell growth, augmented angiogenesis, and tumorigenesis. However, little is known about whether Nox1 signaling regulates cell invasiveness. Here, we report that the cell invasion activity was augmented in K-Ras-transformed normal rat kidney cells and attenuated by transfection of Nox1 small interference RNAs(siRNAs) into the cells. Diphenyleneiodonium (DPI) or Nox1 siRNAs blocked up-regulation of matrix metalloprotease-9 at both protein and mRNA levels in K-Ras-transformed normal rat kidney cells. Furthermore, DPI and Nox1 siRNAs inhibited the activation of IKK alpha kinase and the degradation of I kappa B alpha, suppressing the NF kappa B-dependent matrix metalloprotease-9 promoter activity. Additionally, epidermal growth factor-stimulated migration of CaCO-2 cells was abolished by DPI and Nox1 siRNAs, indicating the requirement of Nox1 activity for the motogenic effect of epidermal growth factor. This Nox1 action was mediated by down-regulation of the Rho activity through the low molecular weight protein-tyrosine phosphatase-p190RhoGAP-dependent mechanism. Taken together, our findings define a mediating role of Nox1-generated reactive oxygen species in cell invasion processes, most notably metalloprotease production and cell motile activity.
ISSN
収録物識別子タイプ PISSN
収録物識別子 0021-9258
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00251083
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/20018867
関連名称 20018867
権利
権利情報 Copyright (c) 2010 The American Society for Biochemistry and Molecular Biology, Inc.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000275274800026
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