{"_buckets": {"deposit": "1ae15cc3-434f-4401-8403-373902998ae9"}, "_deposit": {"id": "3904", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3904"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003904", "sets": ["462"]}, "author_link": ["7885", "7886", "7887", "7888", "7889", "7890", "7891", "7892", "7893"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-12-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "1388", "bibliographicPageStart": "1382", "bibliographicVolumeNumber": "390", "bibliographic_titles": [{"bibliographic_title": "BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Sulfatides, possible antithrombotic factors belonging to sphingoglycolipids, are widely distributed in mammalian tissues and serum. We recently found that the level of serum sulfatides was significantly lower in hemodialysis patients than that in normal subjects, and that the m serum level closely correlated to the incidence of cardiovascular disease. These findings suggest a relationship between the level of serum sulfatides and kidney function; however, the molecular mechanism underlying this relationship remains unclear. In the present study, the influence of kidney dysfunction on the metabolism of sulfatides was examined using an established murine model of acute kidney injury, protein-overload nephropathy in mice. Protein-overload treatment caused severe proximal tubular injuries within 4 days, and this treatment obviously decreased both serum and hepatic sulfatide levels. The sphingoid composition of serum sulfatides was very similar to that of hepatic ones at each time point, suggesting that the serum sulfatide level is dependent on the hepatic secretory ability of sulfatides. The treatment also decreased hepatic expression of cerebroside sulfotransferase (CST), a key enzyme in sulfatide metabolism, while it scarcely influenced the expression of the other sulfatide-metabolizing enzymes, including arylsulfatase A, ceramide galactosyltransferase, and galactosylceramidase. Pro-inflammatory responses were not detected in the liver of these mice: however, potential oxidative stress was increased. These results suggest that down-regulation of hepatic CST expression, probably affected by oxidative stress from kidney injury, causes reduction in liver and serum sulfatide levels. This novel mechanism, indicating the crosstalk between kidney injury and specific liver function, may prove useful for helping to understand the situation where human hemodialysis patients have low levels of serum sulfatides.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット：mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 390(4):1382-1388 (2009)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Nakajima, Takero", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.ymTNuNkh.html"}, {"subitem_link_text": "Kamijo, Yuji", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.gCTFuakh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000272650800056"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "ACADEMIC PRESS INC ELSEVIER SCIENCE"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "19895791"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/19895791", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.bbrc.2009.10.164"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.bbrc.2009.10.164", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright (c) 2009 Elsevier Inc."}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0006-291X", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0006-291X", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00564395", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "Sulfatides; Sphingoglycolipids; Acute kidney injury; Protein-overload nephropathy; Peroxisome proliferator-activated receptor; alpha (Ppara)-null mice; Cerebroside sulfotransferase (CST)"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "ACTIVATED RECEPTOR-ALPHA; CARDIOVASCULAR-DISEASE; PPAR-ALPHA; PEROXISOME PROLIFERATORS; TRANSCRIPTION FACTOR; OXIDATIVE STRESS; SULFOGLYCOLIPIDS; DEFICIENCY; RABBIT; DEHYDROGENASE"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Sulfatides, possible antithrombotic factors belonging to sphingoglycolipids, are widely distributed in mammalian tissues and serum. We recently found that the level of serum sulfatides was significantly lower in hemodialysis patients than that in normal subjects, and that the m serum level closely correlated to the incidence of cardiovascular disease. These findings suggest a relationship between the level of serum sulfatides and kidney function; however, the molecular mechanism underlying this relationship remains unclear. In the present study, the influence of kidney dysfunction on the metabolism of sulfatides was examined using an established murine model of acute kidney injury, protein-overload nephropathy in mice. Protein-overload treatment caused severe proximal tubular injuries within 4 days, and this treatment obviously decreased both serum and hepatic sulfatide levels. The sphingoid composition of serum sulfatides was very similar to that of hepatic ones at each time point, suggesting that the serum sulfatide level is dependent on the hepatic secretory ability of sulfatides. The treatment also decreased hepatic expression of cerebroside sulfotransferase (CST), a key enzyme in sulfatide metabolism, while it scarcely influenced the expression of the other sulfatide-metabolizing enzymes, including arylsulfatase A, ceramide galactosyltransferase, and galactosylceramidase. Pro-inflammatory responses were not detected in the liver of these mice: however, potential oxidative stress was increased. These results suggest that down-regulation of hepatic CST expression, probably affected by oxidative stress from kidney injury, causes reduction in liver and serum sulfatide levels. This novel mechanism, indicating the crosstalk between kidney injury and specific liver function, may prove useful for helping to understand the situation where human hemodialysis patients have low levels of serum sulfatides. (C) 2009 Elsevier Inc. All rights reserved."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Zhang,  Xiaowei", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7885", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakajima,  Takero", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7886", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamijo,  Yuji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7887", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Li,  Gang", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7888", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hu,  Rui", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7889", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kannagi,  Reiji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7890", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kyogashima,  Mamoru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7891", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aoyama,  Toshifumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7892", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hara,  Atsushi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7893", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Acute_kidney_injury.pdf", "filesize": [{"value": "721.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 721200.0, "url": {"label": "Acute_kidney_injury.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3904/files/Acute_kidney_injury.pdf"}, "version_id": "7eef9ba8-8bdf-431b-997a-2366ec700644"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Sulfatides", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Sphingoglycolipids", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Acute kidney injury", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Protein-overload nephropathy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Peroxisome proliferator-activated receptor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "alpha (Ppara)-null mice", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cerebroside sulfotransferase (CST)", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Acute kidney injury induced by protein-overload nephropathy down-regulates gene expression of hepatic cerebroside sulfotransferase in mice, resulting in reduction of liver and serum sulfatides", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Acute kidney injury induced by protein-overload nephropathy down-regulates gene expression of hepatic cerebroside sulfotransferase in mice, resulting in reduction of liver and serum sulfatides", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/10814", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2010-12-02"}, "publish_date": "2010-12-02", "publish_status": "0", "recid": "3904", "relation": {}, "relation_version_is_last": true, "title": ["Acute kidney injury induced by protein-overload nephropathy down-regulates gene expression of hepatic cerebroside sulfotransferase in mice, resulting in reduction of liver and serum sulfatides"], "weko_shared_id": -1}