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A Splice Variant of ASC Regulates IL-1 beta Release and Aggregates Differently from Intact ASC
http://hdl.handle.net/10091/10812
http://hdl.handle.net/10091/108122d581490-c0d6-41ee-845a-500be624c22f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Splice_Variant_ASC_Regulates.pdf (1.9 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2010-12-02 | |||||
| タイトル | ||||||
| タイトル | A Splice Variant of ASC Regulates IL-1 beta Release and Aggregates Differently from Intact ASC | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1155/2009/287387 | |||||
| 関連名称 | 10.1155/2009/287387 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Matsushita, Kazuhiko
× Matsushita, Kazuhiko× Takeoka, Michiko× Sagara, Junji× Itano, Naoki× Kurose, Yuka× Nakamura, Akihiro× Taniguchi, Shun'ichiro |
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| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Taniguchi, Shun'ichiro | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HCyUHCDV.html | |||||
| 出版者 | ||||||
| 出版者 | Hindawi Publishing Corporation | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Mediators of Inflammation. 2009:287387 (2009) | |||||
| 書誌情報 |
Mediators of Inflammation 巻 2009, 発行日 2009 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Copyright (c) 2009 Kazuhiko Matsushita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The apoptosis-associated speck-like protein containing a caspase recruit domain (ASC) is involved in apoptosis and innate immunity and is a major adaptor molecule responsible for procaspase-1 activation. ASC mRNA is encoded by three exons: exons 1 and 3 encode a pyrin domain (PYD) and caspase recruit domain (CARD), respectively, and exon 2 encodes a proline and glycine-rich (PGR) domain. Here, we identified a variant ASC protein (vASC) lacking the PGR domain that was smaller than full length ASC (fASC) derived from fully transcribed mRNA and searched for differences in biochemical and biological nature. Both fASC and vASC were found to activate procaspase-1 to a similar degree, but the efficiency of IL-1 beta excretion was significantly higher for vASC. There was also a marked structural difference observed in the fibrous aggregates formed by fASC and vASC. These results suggest that although the PGR domain is dispensable for procaspase-1 activation, it plays an important role in the regulation of the molecular structure and activity of ASC. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0962-9351 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10844172 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/19759850 | |||||
| 関連名称 | 19759850 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000270782500001 | |||||
