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Vitamin D-3 induces expression of human cathelicidin antimicrobial peptide 18 in newborns
http://hdl.handle.net/10091/10808
http://hdl.handle.net/10091/10808b76943d5-bda8-4736-99a2-049967ee5ecf
| 名前 / ファイル | ライセンス | アクション |
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Vitamin_D-3_induces_expression.pdf (490.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2010-11-30 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Vitamin D-3 induces expression of human cathelicidin antimicrobial peptide 18 in newborns | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| DOI | ||||||||||||||||
| 関連識別子 | https://doi.org/10.1007/s12185-009-0452-9 | |||||||||||||||
| 関連名称 | 10.1007/s12185-009-0452-9 | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | Human, Neutrophils, Phagocytosis | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| タイプ | journal article | |||||||||||||||
| 著者 |
Misawa, Yuka
× Misawa, Yuka
× Baba, Atsushi
× Ito, Susumu
× Tanaka, Miyuki
× Shiohara, Masaaki
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| 出版者 | ||||||||||||||||
| 出版者 | SPRINGER TOKYO | |||||||||||||||
| 引用 | ||||||||||||||||
| 内容記述 | INTERNATIONAL JOURNAL OF HEMATOLOGY. 90(5):561-570 (2009) | |||||||||||||||
| 書誌情報 |
INTERNATIONAL JOURNAL OF HEMATOLOGY 巻 90, 号 5, p. 561-570, 発行日 2009-12 |
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| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | This research was originally published in International Journal of Hematology. Authors. Misawa, Y; Baba, A; Ito, S; Tanaka, M; Shiohara, Title. Vitamin D-3 induces expression of human cathelicidin antimicrobial peptide 18 in newborns, IJH. Year 2009;Vol. 90, Issue. 5:pp561-pp570. Copyright (c) 2009 by The Japanese Society of Hematology. | |||||||||||||||
| 抄録 | ||||||||||||||||
| 内容記述 | Bactericidal activities of neutrophils occur by two distinctive mechanisms that are oxygen-dependent and -independent. Human cathelicidin antimicrobial peptide 18 (hCAP18), also known as LL-37/FALL-39, is a neutrophil-specific granule protein. We compared the content of hCAP18 and neutrophil gelatinase-associated lipocalin (NGAL), another neutrophil-specific granule protein, in neutrophils of both neonates and adults by flow cytometry. The percentage as well as fluorescence intensity ratio of hCAP18 and NGAL expression in neonate neutrophils were significantly lower than in adults. Expression of hCAP18 in monocytes, however, was not significantly different between neonates and adults. Both hCAP18 and NGAL expression increased in an age-dependent fashion. Plasma concentration of these peptides measured by enzyme-linked immunosorbent assay was not significantly different between neonates and adults. Oral intake of 1 alpha hydroxy vitamin D-3 (1 alpha(OH)D-3) in rickets patients for 4 weeks significantly increased hCAP18 expression in neutrophils compared to age-matched healthy controls without 1 alpha(OH)D-3, indicating the potential of vitamin D-3 as a regulator of the innate immune response of neonates. | |||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 0925-5710 | |||||||||||||||
| 書誌レコードID | ||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AA10797094 | |||||||||||||||
| PubMed | ||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/19943126 | |||||||||||||||
| 関連名称 | 19943126 | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
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| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000272640100004 | |||||||||||||||
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Cite as
Misawa, Yuka, Baba, Atsushi, Ito, Susumu, Tanaka, Miyuki, Shiohara, Masaaki, 2009, Vitamin D-3 induces expression of human cathelicidin antimicrobial peptide 18 in newborns: SPRINGER TOKYO, 561–570 p.
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