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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Vitamin D-3 induces expression of human cathelicidin antimicrobial peptide 18 in newborns

http://hdl.handle.net/10091/10808
http://hdl.handle.net/10091/10808
b76943d5-bda8-4736-99a2-049967ee5ecf
名前 / ファイル ライセンス アクション
Vitamin_D-3_induces_expression.pdf Vitamin_D-3_induces_expression.pdf (490.8 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2010-11-30
タイトル
タイトル Vitamin D-3 induces expression of human cathelicidin antimicrobial peptide 18 in newborns
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1007/s12185-009-0452-9
関連名称 10.1007/s12185-009-0452-9
キーワード
主題 Human, Neutrophils, Phagocytosis
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Misawa, Yuka

× Misawa, Yuka

en Misawa, Yuka

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Baba, Atsushi

× Baba, Atsushi

en Baba, Atsushi

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Ito, Susumu

× Ito, Susumu

en Ito, Susumu

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Tanaka, Miyuki

× Tanaka, Miyuki

en Tanaka, Miyuki

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Shiohara, Masaaki

× Shiohara, Masaaki

en Shiohara, Masaaki

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出版者
出版者 SPRINGER TOKYO
引用
内容記述 INTERNATIONAL JOURNAL OF HEMATOLOGY. 90(5):561-570 (2009)
書誌情報 INTERNATIONAL JOURNAL OF HEMATOLOGY

巻 90, 号 5, p. 561-570, 発行日 2009-12
内容記述
内容記述タイプ Other
内容記述 This research was originally published in International Journal of Hematology. Authors. Misawa, Y; Baba, A; Ito, S; Tanaka, M; Shiohara, Title. Vitamin D-3 induces expression of human cathelicidin antimicrobial peptide 18 in newborns, IJH. Year 2009;Vol. 90, Issue. 5:pp561-pp570. Copyright (c) 2009 by The Japanese Society of Hematology.
抄録
内容記述 Bactericidal activities of neutrophils occur by two distinctive mechanisms that are oxygen-dependent and -independent. Human cathelicidin antimicrobial peptide 18 (hCAP18), also known as LL-37/FALL-39, is a neutrophil-specific granule protein. We compared the content of hCAP18 and neutrophil gelatinase-associated lipocalin (NGAL), another neutrophil-specific granule protein, in neutrophils of both neonates and adults by flow cytometry. The percentage as well as fluorescence intensity ratio of hCAP18 and NGAL expression in neonate neutrophils were significantly lower than in adults. Expression of hCAP18 in monocytes, however, was not significantly different between neonates and adults. Both hCAP18 and NGAL expression increased in an age-dependent fashion. Plasma concentration of these peptides measured by enzyme-linked immunosorbent assay was not significantly different between neonates and adults. Oral intake of 1 alpha hydroxy vitamin D-3 (1 alpha(OH)D-3) in rickets patients for 4 weeks significantly increased hCAP18 expression in neutrophils compared to age-matched healthy controls without 1 alpha(OH)D-3, indicating the potential of vitamin D-3 as a regulator of the innate immune response of neonates.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 0925-5710
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10797094
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/19943126
関連名称 19943126
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000272640100004
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Cite as

Misawa, Yuka, Baba, Atsushi, Ito, Susumu, Tanaka, Miyuki, Shiohara, Masaaki, 2009, Vitamin D-3 induces expression of human cathelicidin antimicrobial peptide 18 in newborns: SPRINGER TOKYO, 561–570 p.

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