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To analyse the molecular mechanisms regulating p27 protein, we examined immunohistochemical expression of the SCF\u003cSUSkp2\u003c/SU (Skp1-Cullin-F-box protein) complex factors, i.e. Skp1, Cul1 and Skp2, and compared them with that of p27, steroid receptors and Ki-67. In normal endometrial glands, the expression of Skp2 was observed in the proliferative phase, whereas that of p27 was observed in the secretory phase. Cultured normal endometrial glandular cells showed that progesterone induced the down-regulation of Skp2 along with up-regulation of p27. In endometrial carcinomas, the inverse topological correlation between Skp2 and p27 was evident in 39/66 (59%) cases, and the expression of Skp2 showed a strong correlation with Ki-67. 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Inverse correlation between Skp2 and p27(Kip1) in normal endometrium and endometrial carcinoma
http://hdl.handle.net/10091/10792
http://hdl.handle.net/10091/10792eac9f9c2-4e38-4388-b795-51585586f25e
名前 / ファイル | ライセンス | アクション |
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Inverse_correlation_Skp2_p27.pdf (1.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-11-22 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Inverse correlation between Skp2 and p27(Kip1) in normal endometrium and endometrial carcinoma | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3109/09513590903215482 | |||||
関連名称 | 10.3109/09513590903215482 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Miyamoto, Tsutomu
× Miyamoto, Tsutomu× Horiuchi, Akiko× Kashima, Hiroyasu× Suzuki, Akihisa× Yamada, Tomoko× Kurai, Miyuki× Konishi, Ikuo× Shiozawa, Tanri |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Miyamoto, Tsutomu | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HmfpHVkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Shiozawa, Tanri | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jmyCupkh.html | |||||
出版者 | ||||||
出版者 | INFORMA HEALTHCARE | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | GYNECOLOGICAL ENDOCRINOLOGY. 26(3):220-229 (2010) | |||||
書誌情報 |
GYNECOLOGICAL ENDOCRINOLOGY 巻 26, 号 3, p. 220-229, 発行日 2010-03 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Copyright (c) 2010 Taylor & Francis. This is an electronic version of an article published in "GYNECOLOGICAL ENDOCRINOLOGY, Volume 26, Issue 3, pages 220-229 (2010)". GYNECOLOGICAL ENDOCRINOLOGY is available online at: https://doi.org/10.3109/09513590903215482 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cyclin-dependent-kinase (cdk) inhibitor, p27<SUKip1</SU (p27), has been shown to participate in progestin-induced growth suppression of normal endometrial glands. To analyse the molecular mechanisms regulating p27 protein, we examined immunohistochemical expression of the SCF<SUSkp2</SU (Skp1-Cullin-F-box protein) complex factors, i.e. Skp1, Cul1 and Skp2, and compared them with that of p27, steroid receptors and Ki-67. In normal endometrial glands, the expression of Skp2 was observed in the proliferative phase, whereas that of p27 was observed in the secretory phase. Cultured normal endometrial glandular cells showed that progesterone induced the down-regulation of Skp2 along with up-regulation of p27. In endometrial carcinomas, the inverse topological correlation between Skp2 and p27 was evident in 39/66 (59%) cases, and the expression of Skp2 showed a strong correlation with Ki-67. These findings suggest that the expression of SCF<SUSkp2</SU complex changes during the menstrual cycle in normal endometrium and the SCF<SUSkp2</SU ubiquitin-proteasome pathway may also work in endometrial carcinomas.</. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0951-3590 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10839977 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/19724954 | |||||
関連名称 | 19724954 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000274856700014 |