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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Unusual Clinical and Pathological Presentation of a Neuroendocrine Tumor in a Patient with Multiple Endocrine Neoplasia Type 1

http://hdl.handle.net/10091/10786
http://hdl.handle.net/10091/10786
80d611c6-90ef-45fe-86b3-f86168c629e3
名前 / ファイル ライセンス アクション
Unusual_Clinical_Pathological_Presentation.pdf Unusual_Clinical_Pathological_Presentation.pdf (1.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2010-11-17
タイトル
言語 en
タイトル Unusual Clinical and Pathological Presentation of a Neuroendocrine Tumor in a Patient with Multiple Endocrine Neoplasia Type 1
言語
言語 eng
キーワード
主題Scheme Other
主題 Loss of heterozygosity
キーワード
主題Scheme Other
主題 Two hit theory
キーワード
主題Scheme Other
主題 p27
キーワード
主題Scheme Other
主題 Tumor suppressor
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Sakurai, Akihiro

× Sakurai, Akihiro

WEKO 7978

en Sakurai, Akihiro

Search repository
Murakami, Akiko

× Murakami, Akiko

WEKO 7979

en Murakami, Akiko

Search repository
Sano, Kenji

× Sano, Kenji

WEKO 7980

en Sano, Kenji

Search repository
Uchino, Shinya

× Uchino, Shinya

WEKO 7981

en Uchino, Shinya

Search repository
Fukushima, Yoshimitsu

× Fukushima, Yoshimitsu

WEKO 7982

en Fukushima, Yoshimitsu

Search repository
信州大学研究者総覧へのリンク
氏名 Fukushima, Yoshimitsu
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OUnVuUkh.html
出版者
出版者 JAPAN ENDOCRINE SOC
引用
内容記述タイプ Other
内容記述 ENDOCRINE JOURNAL. 56(7):887-895 (2009)
書誌情報 ENDOCRINE JOURNAL

巻 56, 号 7, p. 887-895, 発行日 2009-10
抄録
内容記述タイプ Abstract
内容記述 Neuroendocrine tumors develop in various organs in patients with multiple endocrine neoplasia type 1 (MEN 1). Among those, tumors developed in upper gastrointestinal tract, thymus and bronchus have historically been called "carcinoid tumor". Occurrence of "carcinoid tumor" in other region is very rare and molecular pathogenesis of such tumors is unknown. We have experienced a patient with MEN1 who have developed an "ectopic" retroperitoneal neuroendocrine tumor. Genetic analysis of the MEN1 gene in tumor cells revealed a somatic mutation in exon 9 as well as a germline mutation in exon 10. Allele-specific amplification followed by sequence analysis revealed these two mutations exist on the different allele, indicating both alleles are functionally inactivated. Immunohistochemical staining with an anti-menin antibody revealed that wild-type menin is not expressed in tumor cells. Expression of p27(Kip1) protein is not observed in tumor cells, either. These results confirmed the inactivation of the MEN1 gene as a genetic cause of an ectopically developed neuroendocrine tumor in a patient with MEN1.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0918-8959
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10901436
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/19564705
関連名称 19564705
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1507/endocrj.K09E-126
関連名称 10.1507/endocrj.K09E-126
権利
権利情報 Copyright (c)The Japan Endocrine Society
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000271260400008
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