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Unusual Clinical and Pathological Presentation of a Neuroendocrine Tumor in a Patient with Multiple Endocrine Neoplasia Type 1
http://hdl.handle.net/10091/10786
http://hdl.handle.net/10091/1078680d611c6-90ef-45fe-86b3-f86168c629e3
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-11-17 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Unusual Clinical and Pathological Presentation of a Neuroendocrine Tumor in a Patient with Multiple Endocrine Neoplasia Type 1 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Loss of heterozygosity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Two hit theory | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p27 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tumor suppressor | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Sakurai, Akihiro
× Sakurai, Akihiro× Murakami, Akiko× Sano, Kenji× Uchino, Shinya× Fukushima, Yoshimitsu |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Fukushima, Yoshimitsu | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OUnVuUkh.html | |||||
出版者 | ||||||
出版者 | JAPAN ENDOCRINE SOC | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | ENDOCRINE JOURNAL. 56(7):887-895 (2009) | |||||
書誌情報 |
ENDOCRINE JOURNAL 巻 56, 号 7, p. 887-895, 発行日 2009-10 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Neuroendocrine tumors develop in various organs in patients with multiple endocrine neoplasia type 1 (MEN 1). Among those, tumors developed in upper gastrointestinal tract, thymus and bronchus have historically been called "carcinoid tumor". Occurrence of "carcinoid tumor" in other region is very rare and molecular pathogenesis of such tumors is unknown. We have experienced a patient with MEN1 who have developed an "ectopic" retroperitoneal neuroendocrine tumor. Genetic analysis of the MEN1 gene in tumor cells revealed a somatic mutation in exon 9 as well as a germline mutation in exon 10. Allele-specific amplification followed by sequence analysis revealed these two mutations exist on the different allele, indicating both alleles are functionally inactivated. Immunohistochemical staining with an anti-menin antibody revealed that wild-type menin is not expressed in tumor cells. Expression of p27(Kip1) protein is not observed in tumor cells, either. These results confirmed the inactivation of the MEN1 gene as a genetic cause of an ectopically developed neuroendocrine tumor in a patient with MEN1. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0918-8959 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10901436 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/19564705 | |||||
関連名称 | 19564705 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1507/endocrj.K09E-126 | |||||
関連名称 | 10.1507/endocrj.K09E-126 | |||||
権利 | ||||||
権利情報 | Copyright (c)The Japan Endocrine Society | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000271260400008 |