WEKO3
アイテム
Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus
http://hdl.handle.net/10091/10785
http://hdl.handle.net/10091/107858b58ab4b-57b3-4ccc-9841-4fecdb17f8de
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Identification_high_incidence_region.pdf (333.1 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-11-16 | |||||
| タイトル | ||||||
| タイトル | Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 関連識別子 | https://doi.org/10.1186/1742-4690-6-79 | |||||
| 関連名称 | 10.1186/1742-4690-6-79 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yamada, Koichiro
× Yamada, Koichiro× Tsukahara, Tomonori× Yoshino, Kazuhisa× Kojima, Katsuhiko× Agawa, Hideyuki× Yamashita, Yuki× Amano, Yuji× Hatta, Mariko× Matsuzaki, Yasunori× Kurotori, Naoki× Wakui, Keiko× Fukushima, Yoshimitsu× Osada, Ryosuke× Shiozawa, Tanri× Sakashita, Kazuo× Koike, Kenichi× Kumaki, Satoru× Tanaka, Nobuyuki× Takeshita, Toshikazu |
|||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Yoshino, Kazuhisa | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WhfFuNkh.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Kojima, Katsuhiko | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OCcFuakh.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Wakui, Keiko | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gVymuakh.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Fukushima, Yoshimitsu | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OUnVuUkh.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Shiozawa, Tanri | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jmyCupkh.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Takeshita, Toshikazu | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.uVLaOmSF.html | |||||
| 出版者 | ||||||
| 出版者 | BIOMED CENTRAL LTD | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Retrovirology. 6:79 (2009) | |||||
| 書誌情報 |
Retrovirology 巻 6, 発行日 2009-09-02 |
|||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | (c) 2009 Yamada et al; licensee BioMed Central Ltd. / This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Therapeutic retroviral vector integration near the oncogene LMO2 is thought to be a cause of leukemia in X-SCID gene therapy trials. However, no published studies have evaluated the frequency of vector integrations near exon 1 of the LMO2 locus. We identified a high incidence region (HIR) of vector integration using PCR techniques in the upstream region close to the LMO2 transcription start site in the TPA-Mat T cell line. The integration frequency of the HIR was one per 4.46 x 10(4) cells. This HIR was also found in Jurkat T cells but was absent from HeLa cells. Furthermore, using human cord blood-derived CD34(+) cells we identified a HIR in a similar region as the TPA-Mat T cell line. One of the X-linked severe combined immunodeficiency (X-SCID) patients that developed leukemia after gene therapy had a vector integration site in this HIR. Therefore, the descriptions of the location and the integration frequency of the HIR presented here may help us to better understand vector-induced leukemogenesis. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1742-4690 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12051445 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/19725963 | |||||
| 関連名称 | 19725963 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000270145800001 | |||||
