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The present authors have previously reported that expression of RhoA is significantly increased in advanced ovarian carcinomas and also in the peritoneal disseminated lesions. The present study investigated whether overexpression of RhoA could alter the progressive behavior of ovarian cancer cells. The effect of various Rho inhibitors on the biological behavior of ovarian cancer cells in vitro and in vivo was also examined. A stable RhoA-transfectant of an ovarian cancer cell line SKOV3 was generated and examined in vitro for alterations of proliferative activity and invasiveness, and also in the nude mice model for peritoneal dissemination. In addition, the effect of a specific Rho inhibitor (C3 exoenzyme), Rho kinase inhibitor (Y27632) and hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (Lovastatin and Pravastatin) were studied in vitro and in vivo. 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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer

http://hdl.handle.net/10091/3211
82b64373-7dee-42f9-b214-dcfd992ff2b6
名前 / ファイル ライセンス アクション
Overexpression_of_RhoA.pdf Overexpression_of_RhoA.pdf (142.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2009-07-17
タイトル
言語 en
タイトル Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Horiuchi, A

× Horiuchi, A

WEKO 8068

en Horiuchi, A

Search repository
Kikuchi, N

× Kikuchi, N

WEKO 8069

en Kikuchi, N

Search repository
Osada, R

× Osada, R

WEKO 8070

en Osada, R

Search repository
Wang, C

× Wang, C

WEKO 8071

en Wang, C

Search repository
Hayashi, A

× Hayashi, A

WEKO 8072

en Hayashi, A

Search repository
Nikaido, T

× Nikaido, T

WEKO 8073

en Nikaido, T

Search repository
Konishi, I

× Konishi, I

WEKO 8074

en Konishi, I

Search repository
出版者
出版者 BLACKWELL PUBLISHING
引用
内容記述タイプ Other
内容記述 CANCER SCIENCE. 99(12):2532-2539 (2008)
書誌情報 CANCER SCIENCE

巻 99, 号 12, p. 2532-2539, 発行日 2008-12
内容記述
内容記述タイプ Other
内容記述 The definitive version is available at www.blackwell-synergy.com
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1347-9032
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11808050
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/j.1349-7006.2008.00977.x
関連名称
関連名称 10.1111/j.1349-7006.2008.00977.x
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000261395300025
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