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We show here that basophils lacking FcR gamma developed normally and proliferated efficiently in response to interleukin 3 (IL-3) but were very impaired in IL-3-induced production of IL-4 and in supporting T helper type 2 differentiation. Through its transmembrane portion, FcR gamma associated constitutively with the common beta-chain of the IL-3 receptor and signaled by recruiting the kinase Syk. Retrovirus-mediated complementation demonstrated the essential function of the ITAM of FcR gamma in IL-3 signal transduction. 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Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils
http://hdl.handle.net/10091/3210
http://hdl.handle.net/10091/321020efcf23-88b7-475b-934e-a6be0b7895e4
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-07-17 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Hida, S
× Hida, S× Yamasaki, S× Sakamoto, Y× Takamoto, M× Obata, K× Takai, T× Karasuyama, H× Sugane, K× Saito, T× Taki, S |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Takamoto, M | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ZUSCupkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Taki, S | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OhnFjeyh.html | |||||
出版者 | ||||||
出版者 | NATURE PUBLISHING GROUP | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | NATURE IMMUNOLOGY. 10(2):214-222 (2009) | |||||
書誌情報 |
NATURE IMMUNOLOGY 巻 10, 号 2, p. 214-222, 発行日 2009-02 |
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資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1529-2908 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11466707 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/19098920 | |||||
関連名称 | 19098920 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/ni.1686 | |||||
関連名称 | 10.1038/ni.1686 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000263178500015 |