{"_buckets": {"deposit": "abb05017-61dd-4758-b9ff-f367e2b9e9bc"}, "_deposit": {"id": "3928", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3928"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003928", "sets": ["461:462"]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "222", "bibliographicPageStart": "214", "bibliographicVolumeNumber": "10", "bibliographic_titles": [{"bibliographic_title": "NATURE IMMUNOLOGY"}]}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8\uff1amime\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "NATURE IMMUNOLOGY. 10(2):214-222 (2009)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Takamoto, M", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.ZUSCupkh.html"}, {"subitem_link_text": "Taki, S", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.OhnFjeyh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000263178500015"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "NATURE PUBLISHING GROUP"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "19098920"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=19098920", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1038/ni.1686"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.1038/ni.1686", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1529-2908", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1529-2908", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11466707", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "PROTEIN-TYROSINE KINASES; SIGNAL-TRANSDUCTION; IN-VIVO; MAST-CELLS; BETA-CHAIN; EPSILON-RI; T-CELLS; CYTOKINE; SYK; MECHANISM"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "The Fc receptor common gamma-chain (FcR gamma) is a widely expressed adaptor bearing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. We show here that basophils lacking FcR gamma developed normally and proliferated efficiently in response to interleukin 3 (IL-3) but were very impaired in IL-3-induced production of IL-4 and in supporting T helper type 2 differentiation. Through its transmembrane portion, FcR gamma associated constitutively with the common beta-chain of the IL-3 receptor and signaled by recruiting the kinase Syk. Retrovirus-mediated complementation demonstrated the essential function of the ITAM of FcR gamma in IL-3 signal transduction. Our results identify a previously unknown mechanism whereby FcR gamma functions to \u0027route\u0027 selective cytokine-triggered signals into the ITAM-mediated IL-4 production pathway."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hida,  S"}], "nameIdentifiers": [{"nameIdentifier": "8075", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamasaki,  S"}], "nameIdentifiers": [{"nameIdentifier": "8076", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakamoto,  Y"}], "nameIdentifiers": [{"nameIdentifier": "8077", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takamoto,  M"}], "nameIdentifiers": [{"nameIdentifier": "8078", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Obata,  K"}], "nameIdentifiers": [{"nameIdentifier": "8079", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takai,  T"}], "nameIdentifiers": [{"nameIdentifier": "8080", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Karasuyama,  H"}], "nameIdentifiers": [{"nameIdentifier": "8081", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugane,  K"}], "nameIdentifiers": [{"nameIdentifier": "8082", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saito,  T"}], "nameIdentifiers": [{"nameIdentifier": "8083", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Taki,  S"}], "nameIdentifiers": [{"nameIdentifier": "8084", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Fc_receptor_gamma-.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "Fc_receptor_gamma-.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3928/files/Fc_receptor_gamma-.pdf"}, "version_id": "90d90b3f-9aff-4e0b-8bf3-c5a67c95507f"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/3210", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2009-07-17"}, "publish_date": "2009-07-17", "publish_status": "0", "recid": "3928", "relation": {}, "relation_version_is_last": true, "title": ["Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils"], "weko_shared_id": 3}