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The number of deaths and death rate of HCC began to increase sharply in 1975. These numbers peaked at 34 510 and 27.4/100 000, respectively, in 2004, but decreased to 33 662 annual deaths and a 26.7/100 000 death rate in 2006. Although hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are both major causes of HCC, HCV-related HCC represents 70% of all cases. The incidence of HCC without hepatitis B surface antigen (HBsAg) or antibodies to HCV (anti-HCV) accounts for 8%-15% of HCC patients nationwide. Geographically, HCC is more frequent in western than eastern Japan, and death rates of HCC in each prefecture correlate with anti-HCV, but not HBsAg, prevalence. Interferon therapy for chronic hepatitis C reduces the risk of development of HCC, especially among patients with sustained virological response. Further research should focus on the mechanisms of carcinogenesis by HCV and HBV, development of more effective treatments, and establishment of early detection and preventative approaches. 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Epidemiology of hepatocellular carcinoma in Japan
http://hdl.handle.net/10091/3206
http://hdl.handle.net/10091/32061eb592b8-5d04-476b-b7f0-d5bbe91ba052
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-07-17 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Epidemiology of hepatocellular carcinoma in Japan | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Umemura, T
× Umemura, T× Ichijo, T× Yoshizawa, K× Tanaka, E× Kiyosawa, K |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Umemura, T | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Tanaka, E | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html | |||||
出版者 | ||||||
出版者 | SPRINGER TOKYO | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JOURNAL OF GASTROENTEROLOGY. 44:102-107 (2009) | |||||
書誌情報 |
JOURNAL OF GASTROENTEROLOGY 巻 44, p. 102-107, 発行日 2009-01 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The original publication is available at www.springerlink.com | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0944-1174 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10988015 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/19148802 | |||||
関連名称 | 19148802 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s00535-008-2251-0 | |||||
関連名称 | 10.1007/s00535-008-2251-0 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
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