WEKO3
アイテム
{"_buckets": {"deposit": "f086b6fa-cb8d-4beb-b6b9-98bda5bf4976"}, "_deposit": {"id": "3932", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3932"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003932", "sets": ["462"]}, "author_link": ["8102", "8103", "8104", "8105", "8106"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "868", "bibliographicPageStart": "862", "bibliographicVolumeNumber": "124", "bibliographic_titles": [{"bibliographic_title": "INTERNATIONAL JOURNAL OF CANCER"}]}]}, "item_6_description_30": {"attribute_name": "資源タイプ(コンテンツの種類)", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット:mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "INTERNATIONAL JOURNAL OF CANCER. 124(4):862-868 (2009)", "subitem_description_type": "Other"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000262618400014"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "WILEY-LISS"}]}, "item_6_relation_46": {"attribute_name": "他の資源との関係:URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://www3.interscience.wiley.com/journal/29331/home"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www3.interscience.wiley.com/journal/29331/home", "subitem_relation_type_select": "URI"}}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "19035443"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/19035443", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1002/ijc.24048"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1002/ijc.24048", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0020-7136", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0020-7136", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00680002", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "melanoma; skin; mucous membrane; oncogene mutation; molecular targets"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "GASTROINTESTINAL STROMAL TUMORS; CELL LUNG-CANCER; C-KIT; MALIGNANT-MELANOMA; IMATINIB MESYLATE; CLINICAL-EFFICACY; FACTOR-RECEPTOR; GROWTH-FACTOR; TYROSINE KINASE; PROTEIN-KINASE"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Recent studies showed KIT gene aberrations in a substantial number of melanomas on acral skin and mucosa, suggesting the therapeutic benefit of tyrosine kinase inhibitors\u0027, such as imatinib. We therefore examined the expression and mutations of KIT in 4 primary and 24 metastatic acral and mucosal melanomas. Immunohistochemistry revealed moderate or strong KIT protein expression in 13 (48%) tumors. Sequence analysis revealed K642E and D820Y mutations in two metastases. Amplification of KIT was identified by real-time PCR in 4 tumors, including one that had K642E. Western blot analysis showed phosphorylation of(he K IT receptor in 8 (62%) of 13 cryopreserved samples. indicating the frequent pathological activation of the receptor in vivo. Phosphorylation of KIT protein was detected in 2 tumors harboring KIT mutations, as well as in one tumor with KIT gene amplification. Furthermore, 5 tumors without detectable KIT gene aberrations showed phosphorylation of the KIT receptor. Expression of stein cell factor (SCF) in melanoma cells as well as stromal cells suggests SCF/KIT autocrine and paracrine activation in these tumors. Finally, we found significant growth suppressive effects of sunitinib in two acral melanoma cell lines; one harboring the D820Y mutation and one showing SCF-dependent KIT activation. These results show pathological activation of KIT in it substantial number of metastatic tumors of acral and mucosal melanomas. and suggest a potential therapeutic benefit of sunitinib for these melanomas. (c) 2008 Wiley-Liss, Inc."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ashida, A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8102", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takata, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8103", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murata, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8104", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kido, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8105", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saida, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8106", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Pathological_activation_of_KIT.pdf", "filesize": [{"value": "268.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 268200.0, "url": {"label": "Pathological_activation_of_KIT.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3932/files/Pathological_activation_of_KIT.pdf"}, "version_id": "a0b724ae-4107-4698-a4dc-932dca4dcff8"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Pathological activation of KIT in metastatic tumors of acral and mucosal melanomas", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Pathological activation of KIT in metastatic tumors of acral and mucosal melanomas", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/3113", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2009-06-19"}, "publish_date": "2009-06-19", "publish_status": "0", "recid": "3932", "relation": {}, "relation_version_is_last": true, "title": ["Pathological activation of KIT in metastatic tumors of acral and mucosal melanomas"], "weko_shared_id": -1}
Pathological activation of KIT in metastatic tumors of acral and mucosal melanomas
http://hdl.handle.net/10091/3113
http://hdl.handle.net/10091/31138d9026c5-9ea0-4df6-bf02-f96c52ffcdaa
名前 / ファイル | ライセンス | アクション |
---|---|---|
Pathological_activation_of_KIT.pdf (268.2 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2009-06-19 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Pathological activation of KIT in metastatic tumors of acral and mucosal melanomas | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1002/ijc.24048 | |||||
関連名称 | 10.1002/ijc.24048 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Ashida, A
× Ashida, A× Takata, M× Murata, H× Kido, K× Saida, T |
|||||
出版者 | ||||||
出版者 | WILEY-LISS | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | INTERNATIONAL JOURNAL OF CANCER. 124(4):862-868 (2009) | |||||
書誌情報 |
INTERNATIONAL JOURNAL OF CANCER 巻 124, 号 4, p. 862-868, 発行日 2009-02 |
|||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0020-7136 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00680002 | |||||
他の資源との関係:URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www3.interscience.wiley.com/journal/29331/home | |||||
関連名称 | http://www3.interscience.wiley.com/journal/29331/home | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/19035443 | |||||
関連名称 | 19035443 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000262618400014 |