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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections

http://hdl.handle.net/10091/3111
http://hdl.handle.net/10091/3111
538eb48c-a471-452f-8678-fd3f4fc803e1
名前 / ファイル ライセンス アクション
PetitPhlebotomyJG-R2.pdf PetitPhlebotomyJG-R2.pdf (103.6 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2009-06-18
タイトル
タイトル Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1007/s00535-009-0034-x
関連名称 10.1007/s00535-009-0034-x
キーワード
主題 Petit phlebotomy, Hepatitis C, Liver cirrhosis, Glycyrrhizin injection, Ferritin, Albumin
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tanaka, Naoki

× Tanaka, Naoki

en Tanaka, Naoki

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Horiuchi, Akira

× Horiuchi, Akira

en Horiuchi, Akira

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Yamaura, Takahiro

× Yamaura, Takahiro

en Yamaura, Takahiro

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Komatsu, Michiharu

× Komatsu, Michiharu

en Komatsu, Michiharu

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Yokoyama, Takahide

× Yokoyama, Takahide

en Yokoyama, Takahide

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Okaniwa, Shinji

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en Okaniwa, Shinji

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Nagaya, Tadanobu

× Nagaya, Tadanobu

en Nagaya, Tadanobu

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Yoshizawa, Kaname

× Yoshizawa, Kaname

en Yoshizawa, Kaname

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Kiyosawa, Kendo

× Kiyosawa, Kendo

en Kiyosawa, Kendo

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Aoyama, Toshifumi

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en Aoyama, Toshifumi

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Tanaka, Eiji

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信州大学研究者総覧へのリンク
氏名 Tanaka, Eiji
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html
出版者
出版者 Springer Japan
引用
内容記述 Journal of Gastroenterology 44(6): 577-582(2009)
書誌情報 Journal of Gastroenterology

巻 44, 号 6, p. 577-582, 発行日 2009-06
内容記述
内容記述タイプ Other
内容記述 The original publication is available at www.springerlink.com
抄録
内容記述 Background: Hepatoprotective therapies that include regular glycyrrhizin injection (GI) are beneficial for chronic hepatitis C patients, but are sometimes unable to normalize serum alanine aminotransferase (ALT) levels. Here, we evaluated whether the addition of minor bloodletting, named petit phlebotomy (PP), prior to each GI could further reduce serum ALT concentrations in such patients. Methods: Seventy-six HCV-infected patients receiving regular GI with persistently abnormal serum ALT levels were randomly divided into GI+PP or GI groups and monitored for 12 months. PP was performed before every GI to a total 60 ml of blood a week. The primary PP endpoint was serum ferritin levels of less than 20 ng/ml. PP was suspended upon reaching the endpoint, but was resumed as needed. The efficacy of the addition of PP was evaluated by measuring changes in serum ALT levels. Results: Two patients in each group dropped out because of apparition of hepatocellular carcinoma. The remainder completed the 12-month treatment with no serious adverse events. Serum ALT and ferritin levels were significantly decreased in the GI+PP group (from 67 + 34 to 44 + 14 U/l and from 163 + 127 to 25 + 21 ng/ml, respectively, both P<0.001), but these changes were not seen in the GI group. Although twenty patients in the GI+PP group had compensated cirrhosis, no significant reductions in serum albumin concentrations were observed. Conclusions: The addition of PP is effective and safe for improving serum aminotransferase levels in HCV-infected patients receiving regular GI, even in those with compensated cirrhosis.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 0944-1174
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10988015
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/19352587
関連名称 19352587
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000266924600009
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Cite as

Tanaka, Naoki, Horiuchi, Akira, Yamaura, Takahiro, Komatsu, Michiharu, Yokoyama, Takahide, Okaniwa, Shinji, Nagaya, Tadanobu, Yoshizawa, Kaname, Kiyosawa, Kendo, Aoyama, Toshifumi, Tanaka, Eiji, 2009, Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections: Springer Japan, 577–582 p.

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