ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "9fe5a40b-72d3-46e9-813f-7a4b5b2cc4b5"}, "_deposit": {"id": "3934", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3934"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003934", "sets": ["462"]}, "author_link": ["8110", "8111", "8112", "8113", "8114", "8115", "8116", "8117", "8118", "8119", "8120"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "582", "bibliographicPageStart": "577", "bibliographicVolumeNumber": "44", "bibliographic_titles": [{"bibliographic_title": "Journal of Gastroenterology"}]}]}, "item_6_description_19": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "The original publication is available at www.springerlink.com", "subitem_description_type": "Other"}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background: Hepatoprotective therapies that include regular glycyrrhizin injection (GI) are beneficial for chronic hepatitis C patients, but are sometimes unable to normalize serum alanine aminotransferase (ALT) levels. Here, we evaluated whether the addition of minor bloodletting, named petit phlebotomy (PP), prior to each GI could further reduce serum ALT concentrations in such patients. Methods: Seventy-six HCV-infected patients receiving regular GI with persistently abnormal serum ALT levels were randomly divided into GI+PP or GI groups and monitored for 12 months. PP was performed before every GI to a total 60 ml of blood a week. The primary PP endpoint was serum ferritin levels of less than 20 ng/ml. PP was suspended upon reaching the endpoint, but was resumed as needed. The efficacy of the addition of PP was evaluated by measuring changes in serum ALT levels. Results: Two patients in each group dropped out because of apparition of hepatocellular carcinoma. The remainder completed the 12-month treatment with no serious adverse events. Serum ALT and ferritin levels were significantly decreased in the GI+PP group (from 67 + 34 to 44 + 14 U/l and from 163 + 127 to 25 + 21 ng/ml, respectively, both P\u003c0.001), but these changes were not seen in the GI group. Although twenty patients in the GI+PP group had compensated cirrhosis, no significant reductions in serum albumin concentrations were observed. Conclusions: The addition of PP is effective and safe for improving serum aminotransferase levels in HCV-infected patients receiving regular GI, even in those with compensated cirrhosis.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ(コンテンツの種類)", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット:mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Journal of Gastroenterology 44(6): 577-582(2009)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Tanaka, Eiji", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000266924600009"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer Japan"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "19352587"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/19352587", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1007/s00535-009-0034-x"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s00535-009-0034-x", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0944-1174", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0944-1174", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10988015", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "Petit phlebotomy; Hepatitis C; Liver cirrhosis; Glycyrrhizin injection; Ferritin; Albumin"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "ALANINE AMINOTRANSFERASE LEVELS; IRON REDUCTION THERAPY; HEPATOCELLULAR-CARCINOMA; NONALCOHOLIC STEATOHEPATITIS; SERUM AMINOTRANSFERASE; LIVER-CIRRHOSIS; DIET"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Hepatoprotective therapies that include regular glycyrrhizin injections (GIs) are beneficial for chronic hepatitis C patients, but are sometimes insufficient for normalizing serum alanine aminotransferase (ALT) levels. Here, we evaluated whether the addition of minor bloodletting, named petit phlebotomy (PP), prior to each GI could further reduce serum ALT concentrations in such patients. Seventy-six hepatitis C virus (HCV)-infected patients receiving regular GI, with persistently abnormal serum ALT levels, were randomly divided into GI + PP and GI groups and monitored for 12 months. PP was performed before every GI to a total 60 ml of blood a week. The primary PP endpoint was a serum ferritin level of less than 20 ng/ml. PP was suspended upon reaching the endpoint, but was resumed as needed. The efficacy of the addition of PP was evaluated by measuring changes in serum ALT levels. Two patients in each group dropped out because of the appearance of hepatocellular carcinoma. The remainder completed the 12-month treatment with no serious adverse events. Serum ALT and ferritin levels were significantly decreased in the GI + PP group (from 67 +/- A 34 to 44 +/- A 14 U/l and from 163 +/- A 127 to 25 +/- A 21 ng/ml, respectively, both P \u003c 0.001), but these changes were not seen in the GI group. Although 20 patients in the GI + PP group had compensated cirrhosis, no significant reductions in serum albumin concentrations were observed. The addition of PP is effective and safe for improving serum aminotransferase levels in HCV-infected patients receiving regular GI, even in those with compensated cirrhosis."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tanaka,  Naoki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8110", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Horiuchi,  Akira", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8111", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamaura,  Takahiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8112", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Komatsu,  Michiharu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8113", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yokoyama,  Takahide", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8114", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okaniwa,  Shinji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8115", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagaya,  Tadanobu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8116", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshizawa,  Kaname", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8117", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyosawa,  Kendo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8118", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aoyama,  Toshifumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8119", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka,  Eiji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8120", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PetitPhlebotomyJG-R2.pdf", "filesize": [{"value": "103.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 103600.0, "url": {"label": "PetitPhlebotomyJG-R2.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3934/files/PetitPhlebotomyJG-R2.pdf"}, "version_id": "b41d5784-e897-430b-929c-d89fb83cc08f"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Petit phlebotomy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Hepatitis C", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Liver cirrhosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Glycyrrhizin injection", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ferritin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Albumin", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/3111", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2009-06-18"}, "publish_date": "2009-06-18", "publish_status": "0", "recid": "3934", "relation": {}, "relation_version_is_last": true, "title": ["Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections"], "weko_shared_id": -1}
  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections

http://hdl.handle.net/10091/3111
http://hdl.handle.net/10091/3111
538eb48c-a471-452f-8678-fd3f4fc803e1
名前 / ファイル ライセンス アクション
PetitPhlebotomyJG-R2.pdf PetitPhlebotomyJG-R2.pdf (103.6 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2009-06-18
タイトル
言語 en
タイトル Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections
言語
言語 eng
キーワード
主題Scheme Other
主題 Petit phlebotomy
キーワード
主題Scheme Other
主題 Hepatitis C
キーワード
主題Scheme Other
主題 Liver cirrhosis
キーワード
主題Scheme Other
主題 Glycyrrhizin injection
キーワード
主題Scheme Other
主題 Ferritin
キーワード
主題Scheme Other
主題 Albumin
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tanaka, Naoki

× Tanaka, Naoki

WEKO 8110

en Tanaka, Naoki

Search repository
Horiuchi, Akira

× Horiuchi, Akira

WEKO 8111

en Horiuchi, Akira

Search repository
Yamaura, Takahiro

× Yamaura, Takahiro

WEKO 8112

en Yamaura, Takahiro

Search repository
Komatsu, Michiharu

× Komatsu, Michiharu

WEKO 8113

en Komatsu, Michiharu

Search repository
Yokoyama, Takahide

× Yokoyama, Takahide

WEKO 8114

en Yokoyama, Takahide

Search repository
Okaniwa, Shinji

× Okaniwa, Shinji

WEKO 8115

en Okaniwa, Shinji

Search repository
Nagaya, Tadanobu

× Nagaya, Tadanobu

WEKO 8116

en Nagaya, Tadanobu

Search repository
Yoshizawa, Kaname

× Yoshizawa, Kaname

WEKO 8117

en Yoshizawa, Kaname

Search repository
Kiyosawa, Kendo

× Kiyosawa, Kendo

WEKO 8118

en Kiyosawa, Kendo

Search repository
Aoyama, Toshifumi

× Aoyama, Toshifumi

WEKO 8119

en Aoyama, Toshifumi

Search repository
Tanaka, Eiji

× Tanaka, Eiji

WEKO 8120

en Tanaka, Eiji

Search repository
信州大学研究者総覧へのリンク
氏名 Tanaka, Eiji
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html
出版者
出版者 Springer Japan
引用
内容記述タイプ Other
内容記述 Journal of Gastroenterology 44(6): 577-582(2009)
書誌情報 Journal of Gastroenterology

巻 44, 号 6, p. 577-582, 発行日 2009-06
内容記述
内容記述タイプ Other
内容記述 The original publication is available at www.springerlink.com
抄録
内容記述タイプ Abstract
内容記述 Background: Hepatoprotective therapies that include regular glycyrrhizin injection (GI) are beneficial for chronic hepatitis C patients, but are sometimes unable to normalize serum alanine aminotransferase (ALT) levels. Here, we evaluated whether the addition of minor bloodletting, named petit phlebotomy (PP), prior to each GI could further reduce serum ALT concentrations in such patients. Methods: Seventy-six HCV-infected patients receiving regular GI with persistently abnormal serum ALT levels were randomly divided into GI+PP or GI groups and monitored for 12 months. PP was performed before every GI to a total 60 ml of blood a week. The primary PP endpoint was serum ferritin levels of less than 20 ng/ml. PP was suspended upon reaching the endpoint, but was resumed as needed. The efficacy of the addition of PP was evaluated by measuring changes in serum ALT levels. Results: Two patients in each group dropped out because of apparition of hepatocellular carcinoma. The remainder completed the 12-month treatment with no serious adverse events. Serum ALT and ferritin levels were significantly decreased in the GI+PP group (from 67 + 34 to 44 + 14 U/l and from 163 + 127 to 25 + 21 ng/ml, respectively, both P<0.001), but these changes were not seen in the GI group. Although twenty patients in the GI+PP group had compensated cirrhosis, no significant reductions in serum albumin concentrations were observed. Conclusions: The addition of PP is effective and safe for improving serum aminotransferase levels in HCV-infected patients receiving regular GI, even in those with compensated cirrhosis.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0944-1174
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10988015
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/19352587
関連名称 19352587
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s00535-009-0034-x
関連名称 10.1007/s00535-009-0034-x
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000266924600009
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 07:49:51.764892
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3