| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-06-18 |
| タイトル |
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|
タイトル |
Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections |
| 言語 |
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言語 |
eng |
| DOI |
|
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関連識別子 |
https://doi.org/10.1007/s00535-009-0034-x |
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関連名称 |
10.1007/s00535-009-0034-x |
| キーワード |
|
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主題 |
Petit phlebotomy, Hepatitis C, Liver cirrhosis, Glycyrrhizin injection, Ferritin, Albumin |
| 資源タイプ |
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|
資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Tanaka, Naoki
Horiuchi, Akira
Yamaura, Takahiro
Komatsu, Michiharu
Yokoyama, Takahide
Okaniwa, Shinji
Nagaya, Tadanobu
Yoshizawa, Kaname
Kiyosawa, Kendo
Aoyama, Toshifumi
Tanaka, Eiji
|
| 信州大学研究者総覧へのリンク |
|
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氏名 |
Tanaka, Eiji |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html |
| 出版者 |
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出版者 |
Springer Japan |
| 引用 |
|
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内容記述 |
Journal of Gastroenterology 44(6): 577-582(2009) |
| 書誌情報 |
Journal of Gastroenterology
巻 44,
号 6,
p. 577-582,
発行日 2009-06
|
| 内容記述 |
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内容記述タイプ |
Other |
|
内容記述 |
The original publication is available at www.springerlink.com |
| 抄録 |
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内容記述 |
Background: Hepatoprotective therapies that include regular glycyrrhizin injection (GI) are beneficial for chronic hepatitis C patients, but are sometimes unable to normalize serum alanine aminotransferase (ALT) levels. Here, we evaluated whether the addition of minor bloodletting, named petit phlebotomy (PP), prior to each GI could further reduce serum ALT concentrations in such patients. Methods: Seventy-six HCV-infected patients receiving regular GI with persistently abnormal serum ALT levels were randomly divided into GI+PP or GI groups and monitored for 12 months. PP was performed before every GI to a total 60 ml of blood a week. The primary PP endpoint was serum ferritin levels of less than 20 ng/ml. PP was suspended upon reaching the endpoint, but was resumed as needed. The efficacy of the addition of PP was evaluated by measuring changes in serum ALT levels. Results: Two patients in each group dropped out because of apparition of hepatocellular carcinoma. The remainder completed the 12-month treatment with no serious adverse events. Serum ALT and ferritin levels were significantly decreased in the GI+PP group (from 67 + 34 to 44 + 14 U/l and from 163 + 127 to 25 + 21 ng/ml, respectively, both P<0.001), but these changes were not seen in the GI group. Although twenty patients in the GI+PP group had compensated cirrhosis, no significant reductions in serum albumin concentrations were observed. Conclusions: The addition of PP is effective and safe for improving serum aminotransferase levels in HCV-infected patients receiving regular GI, even in those with compensated cirrhosis. |
| 資源タイプ（コンテンツの種類） |
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0944-1174 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10988015 |
| PubMed |
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|
識別子タイプ |
PMID |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/19352587 |
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|
関連名称 |
19352587 |
| 出版タイプ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| WoS |
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|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000266924600009 |
PetitPhlebotomyJG-R2.pdf (103.6 kB)
