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We prospectively studied the clinical usefulness of cyclic VAD (vincristine, doxorubicin and dexamethasone) in patients with primary systemic AL amyloidosis who were ineligible for high-dose melphalan with autologous stem cell support. Patients and Methods Eight patients (mean age, 60.4+/-8.8 years) were treated with cyclic VAD until the disappearance of M-protein from both serum and urine. Of these, seven showed nephrotic syndrome before the start of VAD irrespective of a decrease in creatinine clearance. Serial follow-up studies after VAD evaluated hematological status and organ function. Results Four patients (50%) showed a marked decrease in abnormal plasma cells in the bone marrow and normalized kappa/lambda ratios of serum free light chain in conjunction with disappearance of M-protein after 1 to 3 courses of VAD. There were no serious adverse events, and nephrotic syndrome gradually improved with no hematological relapse in the follow-up period of 3 to 5 years. The remaining 4 patients showed worsening of congestive heart failure and/or systemic edema ascribable to dexamethasone, resulting in cessation of cyclic VAD before disappearance of M-protein. All of these patients died of multiple organ failure or required permanent hemodialysis within 1 year after the start of cyclic VAD. Conclusion Cyclic VAD is a potent therapeutic option in primary systemic AL amyloidosis, but in patients with renal or cardiac dysfunction careful management for adverse events, especially body fluid retention, is necessary."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tazawa,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8274", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuda,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8275", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshida,  T"}], "nameIdentifiers": [{"nameIdentifier": "8276", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Gono,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8277", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Katoh,  N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8278", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimojima,  Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8279", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishii,  W", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8280", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fushimi,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8281", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koyama,  J", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8282", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikeda,  SI", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8283", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "VAD-IM.pdf", "filesize": [{"value": "207.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 207900.0, "url": {"label": "VAD-IM.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3962/files/VAD-IM.pdf"}, "version_id": "5c34843e-8752-46d3-8c97-90d4241f0b9f"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Therapeutic outcome of cyclic VAD (vincristine, doxorubicin and dexamethasone) therapy in primary systemic AL amyloidosis patients", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Therapeutic outcome of cyclic VAD (vincristine, doxorubicin and dexamethasone) therapy in primary systemic AL amyloidosis patients", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/1386", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-10-30"}, "publish_date": "2008-10-30", "publish_status": "0", "recid": "3962", "relation": {}, "relation_version_is_last": true, "title": ["Therapeutic outcome of cyclic VAD (vincristine, doxorubicin and dexamethasone) therapy in primary systemic AL amyloidosis patients"], "weko_shared_id": -1}
  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Therapeutic outcome of cyclic VAD (vincristine, doxorubicin and dexamethasone) therapy in primary systemic AL amyloidosis patients

http://hdl.handle.net/10091/1386
381d57f3-2590-4687-9101-10c4a844b504
名前 / ファイル ライセンス アクション
VAD-IM.pdf VAD-IM.pdf (207.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2008-10-30
タイトル
言語 en
タイトル Therapeutic outcome of cyclic VAD (vincristine, doxorubicin and dexamethasone) therapy in primary systemic AL amyloidosis patients
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tazawa, K

× Tazawa, K

WEKO 8274

en Tazawa, K

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Matsuda, M

× Matsuda, M

WEKO 8275

en Matsuda, M

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Yoshida, T

× Yoshida, T

WEKO 8276

Yoshida, T

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Gono, T

× Gono, T

WEKO 8277

en Gono, T

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Katoh, N

× Katoh, N

WEKO 8278

en Katoh, N

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Shimojima, Y

× Shimojima, Y

WEKO 8279

en Shimojima, Y

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Ishii, W

× Ishii, W

WEKO 8280

en Ishii, W

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Fushimi, T

× Fushimi, T

WEKO 8281

en Fushimi, T

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Koyama, J

× Koyama, J

WEKO 8282

en Koyama, J

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Ikeda, SI

× Ikeda, SI

WEKO 8283

en Ikeda, SI

Search repository
出版者
出版者 JAPAN SOC INTERNAL MEDICINE
引用
内容記述タイプ Other
内容記述 INTERNAL MEDICINE. 47(17):1517-1522(2008)
書誌情報 INTERNAL MEDICINE

巻 47, 号 17, p. 1517-1522, 発行日 2008
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0918-2918
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10827774
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.2169/internalmedicine.47.0949
関連名称
関連名称 10.2169/internalmedicine.47.0949
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000259221300004
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