WEKO3
アイテム
{"_buckets": {"deposit": "21a022e8-0aa3-4514-85fc-8896d48028e1"}, "_deposit": {"id": "3962", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3962"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003962", "sets": ["462"]}, "author_link": ["8274", "8275", "8276", "8277", "8278", "8279", "8280", "8281", "8282", "8283"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "17", "bibliographicPageEnd": "1522", "bibliographicPageStart": "1517", "bibliographicVolumeNumber": "47", "bibliographic_titles": [{"bibliographic_title": "INTERNAL MEDICINE"}]}]}, "item_6_description_30": {"attribute_name": "資源タイプ(コンテンツの種類)", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット:mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "INTERNAL MEDICINE. 47(17):1517-1522(2008)", "subitem_description_type": "Other"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000259221300004"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "JAPAN SOC INTERNAL MEDICINE"}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.2169/internalmedicine.47.0949"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.2169/internalmedicine.47.0949", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0918-2918", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0918-2918", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10827774", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "primary systemic AL amyloidosis; cyclic VAD (vincristine, doxorubicin and dexamethasone); plasma cell dyscrasia; nephrotic syndrome"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "STEM-CELL TRANSPLANTATION; HIGH-DOSE MELPHALAN; LIGHT-CHAIN AMYLOIDOSIS; NEPHROTIC SYNDROME; MULTIPLE-MYELOMA; SUPPORT; CHEMOTHERAPY; CRITERIA"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Objective Intensive chemotherapy targeting plasma cell dyscrasia has been recently employed for the treatment of primary systemic AL amyloidosis. We prospectively studied the clinical usefulness of cyclic VAD (vincristine, doxorubicin and dexamethasone) in patients with primary systemic AL amyloidosis who were ineligible for high-dose melphalan with autologous stem cell support. Patients and Methods Eight patients (mean age, 60.4+/-8.8 years) were treated with cyclic VAD until the disappearance of M-protein from both serum and urine. Of these, seven showed nephrotic syndrome before the start of VAD irrespective of a decrease in creatinine clearance. Serial follow-up studies after VAD evaluated hematological status and organ function. Results Four patients (50%) showed a marked decrease in abnormal plasma cells in the bone marrow and normalized kappa/lambda ratios of serum free light chain in conjunction with disappearance of M-protein after 1 to 3 courses of VAD. There were no serious adverse events, and nephrotic syndrome gradually improved with no hematological relapse in the follow-up period of 3 to 5 years. The remaining 4 patients showed worsening of congestive heart failure and/or systemic edema ascribable to dexamethasone, resulting in cessation of cyclic VAD before disappearance of M-protein. All of these patients died of multiple organ failure or required permanent hemodialysis within 1 year after the start of cyclic VAD. Conclusion Cyclic VAD is a potent therapeutic option in primary systemic AL amyloidosis, but in patients with renal or cardiac dysfunction careful management for adverse events, especially body fluid retention, is necessary."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tazawa, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8274", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuda, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8275", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshida, T"}], "nameIdentifiers": [{"nameIdentifier": "8276", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Gono, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8277", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Katoh, N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8278", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimojima, Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8279", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishii, W", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8280", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fushimi, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8281", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koyama, J", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8282", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikeda, SI", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8283", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "VAD-IM.pdf", "filesize": [{"value": "207.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 207900.0, "url": {"label": "VAD-IM.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3962/files/VAD-IM.pdf"}, "version_id": "5c34843e-8752-46d3-8c97-90d4241f0b9f"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Therapeutic outcome of cyclic VAD (vincristine, doxorubicin and dexamethasone) therapy in primary systemic AL amyloidosis patients", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Therapeutic outcome of cyclic VAD (vincristine, doxorubicin and dexamethasone) therapy in primary systemic AL amyloidosis patients", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/1386", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-10-30"}, "publish_date": "2008-10-30", "publish_status": "0", "recid": "3962", "relation": {}, "relation_version_is_last": true, "title": ["Therapeutic outcome of cyclic VAD (vincristine, doxorubicin and dexamethasone) therapy in primary systemic AL amyloidosis patients"], "weko_shared_id": -1}
Therapeutic outcome of cyclic VAD (vincristine, doxorubicin and dexamethasone) therapy in primary systemic AL amyloidosis patients
http://hdl.handle.net/10091/1386
http://hdl.handle.net/10091/1386381d57f3-2590-4687-9101-10c4a844b504
名前 / ファイル | ライセンス | アクション |
---|---|---|
![]() |
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2008-10-30 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Therapeutic outcome of cyclic VAD (vincristine, doxorubicin and dexamethasone) therapy in primary systemic AL amyloidosis patients | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Tazawa, K
× Tazawa, K× Matsuda, M× Yoshida, T× Gono, T× Katoh, N× Shimojima, Y× Ishii, W× Fushimi, T× Koyama, J× Ikeda, SI |
|||||
出版者 | ||||||
出版者 | JAPAN SOC INTERNAL MEDICINE | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | INTERNAL MEDICINE. 47(17):1517-1522(2008) | |||||
書誌情報 |
INTERNAL MEDICINE 巻 47, 号 17, p. 1517-1522, 発行日 2008 |
|||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0918-2918 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10827774 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.2169/internalmedicine.47.0949 | |||||
関連名称 | 10.2169/internalmedicine.47.0949 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000259221300004 |