{"_buckets": {"deposit": "56808a03-5c30-4d5b-84fa-a938570bbbb8"}, "_deposit": {"id": "3966", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3966"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003966", "sets": ["462"]}, "author_link": ["8298", "8299", "8300", "8301", "8302"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2007", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "15", "bibliographicPageEnd": "1249", "bibliographicPageStart": "1247", "bibliographicVolumeNumber": "46", "bibliographic_titles": [{"bibliographic_title": "INTERNAL MEDICINE"}]}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット：mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "INTERNAL MEDICINE. 46(15):1247-1249(2007)", "subitem_description_type": "Other"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000258844500017"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "JAPAN SOC INTERNAL MEDICINE"}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.2169/internalmedicine.46.0064"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.2169/internalmedicine.46.0064", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0918-2918", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0918-2918", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10827774", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "familial Mediterranean fever; infliximab; methotrexate; tumor necrosis factor-alpha"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "ATTACKS; VARIANT; PYRIN; ALPHA"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "We report a Japanese patient with familial Mediterranean fever (FMF) who was successfully treated with the anti-tumor necrosis factor (TNF)-alpha monoclonal antibody, infliximab, and low-dose methotrexate. This patient was diagnosed as having FMF based on periodic fever with polyarthralgia typical of this disease and heterozygous mutations in the MEFV gene. Conventional treatment, such as colchicine and reserpine, failed to sufficiently control the FMF attacks. After starting infliximab (3 mg/kg) and low-dose methotrexate (6 mg/week), the frequency of the FMF attacks dramatically decreased and the clinical effect has remained unchanged for longer than 1 year. Combination therapy with infliximab and low-dose methotrexate may be a potent therapeutic option for FMF patients, particularly when conventional treatment is ineffective or cannot be employed because of adverse events."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakamura,  A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8298", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuda,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8299", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tazawa,  KI", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8300", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimojima,  Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8301", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikeda,  SI", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8302", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Infliximab-FMF[1]..pdf", "filesize": [{"value": "87.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 87100.0, "url": {"label": "Infliximab-FMF[1]..pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3966/files/Infliximab-FMF[1]..pdf"}, "version_id": "d4eb4602-e34c-435e-91b4-4858ea6594b8"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Successful treatment with infliximab and low-dose methotrexate in a Japanese patient with familial Mediterranean fever", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Successful treatment with infliximab and low-dose methotrexate in a Japanese patient with familial Mediterranean fever", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/1188", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-10-22"}, "publish_date": "2008-10-22", "publish_status": "0", "recid": "3966", "relation": {}, "relation_version_is_last": true, "title": ["Successful treatment with infliximab and low-dose methotrexate in a Japanese patient with familial Mediterranean fever"], "weko_shared_id": -1}