{"_buckets": {"deposit": "b4c82a4f-6dcb-4d37-af13-8fd6ccda48f7"}, "_deposit": {"id": "3972", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3972"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003972", "sets": ["462"]}, "author_link": ["8338", "8339", "8340", "8341", "8342", "8343", "8344", "8345", "8346", "8347", "8348"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-07-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "119", "bibliographicPageStart": "108", "bibliographicVolumeNumber": "76", "bibliographic_titles": [{"bibliographic_title": "BIOCHEMICAL PHARMACOLOGY"}]}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット：mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "BIOCHEMICAL PHARMACOLOGY. 76(1):108-119(2008)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Kamijo, Y", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.gCTFuakh.html"}, {"subitem_link_text": "Nakamura, K", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.upyCPUkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000257847200012"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "PERGAMON-ELSEVIER SCIENCE LTD"}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.bcp.2008.04.001"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.bcp.2008.04.001", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0006-2952", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0006-2952", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00564486", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "bezafibrate; peroxisome proliferator-activated receptor (PPAR); Ppara-null mice; cholesterol metabolism; sterol regulatory element-binding protein (SREBP) 2"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "PRIMARY BILIARY-CIRRHOSIS; ACID-BINDING PROTEIN; ALPHA PPAR-ALPHA; BILE-ACID; HDL CHOLESTEROL; RAT-LIVER; LIPOPROTEIN METABOLISM; GLUCOSE-METABOLISM; LIPID-SYNTHESIS; HEPATIC ABCA1"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "The hypocholesterolemic potential of peroxisome proliferator-activated receptor (PPAR) pan-activator bezafibrate has been documented. However, in addition to uncertainty about the contribution of PPAR alpha to its effect, there is a marked discrepancy in bezafibrate dosages used in previous rodent experiments (\u003e= 50 mg/kg/day) and those in clinical use (\u003c= 10 mg/kg/ day). To investigate the association between bezafibrate-induced cholesterol reduction and PPARa activation, wild-type and Ppara-null mice were treated with bezafibrate at high (100 mg/kg/day) or low (10 mg/kg/day) doses and analyzed. High-dose treatment decreased hepatic cholesterol content in wild-type mice, but increased serum cholesterol concentration. In liver samples, simultaneous increases in the expression of numerous proteins involved in cholesterol biosynthesis and catabolism, as well as cholesterol influx and efflux, were observed, which made interpretation of phenotype changes subtle. These complicated responses were believed to be associated with intensive PPAR activation and accompanying up-regulation of liver X receptor a, farnesoid X receptor, and sterol regulatory element-binding protein 2 (SREBP2). In contrast, low-dose bezafibrate treatment decreased serum and hepatic cholesterol concentrations in a PPAR alpha-independent manner, probably from suppression of SREBP2-regulated cholesterogenesis and enhancement of cholesterol catabolism due to elevated 7 alpha-hydroxylase levels. Interestingly, the low-dose treatment did not affect the expression of PPAR target genes or number of peroxisomes, suggesting the absence of PPAR activation. These results demonstrate that the action of bezafibrate on cholesterol metabolism may vary with dosage, and that the cholesterol-reducing effect found in mice at dosages similar to those administered to humans is independent of significant PPAR activation. (c) 2008 Elsevier Inc. All rights reserved."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakajima,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8338", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka,  N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8339", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugiyama,  E", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8340", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamijo,  Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8341", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hara,  A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8342", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hu,  R", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8343", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Li,  G", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8344", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Li,  YF", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8345", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8346", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Gonzalez,  FJ", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8347", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aoyama,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8348", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Beza-cholesterolBP-R1[1].pdf", "filesize": [{"value": "149.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 149600.0, "url": {"label": "Beza-cholesterolBP-R1[1].pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3972/files/Beza-cholesterolBP-R1[1].pdf"}, "version_id": "c86f0f4a-0611-4935-a196-d87ee4cf0438"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/1135", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-09-04"}, "publish_date": "2008-09-04", "publish_status": "0", "recid": "3972", "relation": {}, "relation_version_is_last": true, "title": ["Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice"], "weko_shared_id": -1}