{"_buckets": {"deposit": "583fa605-0fc5-44b3-bda2-7edee0846efc"}, "_deposit": {"id": "3974", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3974"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003974", "sets": ["462"]}, "author_link": ["8357", "8358", "8359", "8360", "8361", "8362"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "166", "bibliographicPageStart": "151", "bibliographicVolumeNumber": "222", "bibliographic_titles": [{"bibliographic_title": "JOURNAL OF MEMBRANE BIOLOGY"}]}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット：mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "JOURNAL OF MEMBRANE BIOLOGY. 222(3): 151-166(2008)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Yamada, M", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.jhSCupca.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000257208400005"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "SPRINGER"}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1007/s00232-008-9113-9"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s00232-008-9113-9", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0022-2631", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0022-2631", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00702466", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "early afterdepolarization; I-Kr channel; I-Ks channel; L-type; Ca2+ channel; long QT syndrome; action potential clamp; cardiac electrophysiology"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "LONG QT SYNDROME; SODIUM-CALCIUM EXCHANGER; ACTION-POTENTIAL CLAMP; RECTIFIER K+ CURRENT; CELLULAR MECHANISMS; IONIC CURRENTS; INACTIVATION; HEART; ARRHYTHMIAS; CELLS"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Early afterdepolizations (EADs) induced by suppression of cardiac delayed rectifier I-Kr and/or I-Ks channels cause fatal ventricular tachyarrhythmias. In guinea pig ventricular myocytes, partial block of one of the channels with complete block of the other reproducibly induced EADs. Complete block of both I-Kr and I-Ks channels depolarized the take-off potential and reduced the amplitude of EADs, which in some cases were not clearly separated from the preceding action potentials. A selective L-type Ca2+ (I-Ca,I-L) channel blocker, nifedipine, effectively suppressed EADs at submicromolar concentrations. As examined with the action potential-clamp method, I-Ca,I-L channels mediated inward currents with a spike and dome shape during action potentials. I-Ca,I-L currents decayed mainly due to inactivation in phase 2 and deactivation in phase 3 repolarization. When EADs were induced by complete block of I-Kr channels with partial block of I-Ks channels, repolarization of the action potential prior to EAD take-off failed to increase I-K1 currents and thus failed to completely deactivate I-Ca,I-L channels, which reactivated and mediated inward currents during EADs. When both I-Kr and I-Ks channels were completely blocked, I-Ca,I-L channels were not deactivated and mediated sustained inward currents until the end of EADs. Under this condition, the recovery and reactivation of I (Ca,L) channels were absent before EADs. Therefore, an essential mechanism underlying EADs caused by suppression of the delayed rectifiers is the failure to completely deactivate I-Ca,I-L channels."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamada,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8357", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohta,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8358", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niwa,  A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8359", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsujino,  N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8360", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakada,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8361", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirose,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8362", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "山田充彦.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "山田充彦.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3974/files/山田充彦.pdf"}, "version_id": "ccdb5e1f-9953-4ca4-a1aa-0d22e66d6d54"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I-Kr and I-Ks channel suppression in guinea pig ventricular myocytes", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I-Kr and I-Ks channel suppression in guinea pig ventricular myocytes", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/1122", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-08-08"}, "publish_date": "2008-08-08", "publish_status": "0", "recid": "3974", "relation": {}, "relation_version_is_last": true, "title": ["Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I-Kr and I-Ks channel suppression in guinea pig ventricular myocytes"], "weko_shared_id": -1}