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In guinea pig ventricular myocytes, partial block of one of the channels with complete block of the other reproducibly induced EADs. Complete block of both I-Kr and I-Ks channels depolarized the take-off potential and reduced the amplitude of EADs, which in some cases were not clearly separated from the preceding action potentials. A selective L-type Ca2+ (I-Ca,I-L) channel blocker, nifedipine, effectively suppressed EADs at submicromolar concentrations. As examined with the action potential-clamp method, I-Ca,I-L channels mediated inward currents with a spike and dome shape during action potentials. I-Ca,I-L currents decayed mainly due to inactivation in phase 2 and deactivation in phase 3 repolarization. When EADs were induced by complete block of I-Kr channels with partial block of I-Ks channels, repolarization of the action potential prior to EAD take-off failed to increase I-K1 currents and thus failed to completely deactivate I-Ca,I-L channels, which reactivated and mediated inward currents during EADs. When both I-Kr and I-Ks channels were completely blocked, I-Ca,I-L channels were not deactivated and mediated sustained inward currents until the end of EADs. Under this condition, the recovery and reactivation of I (Ca,L) channels were absent before EADs. Therefore, an essential mechanism underlying EADs caused by suppression of the delayed rectifiers is the failure to completely deactivate I-Ca,I-L channels."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamada,  M"}], "nameIdentifiers": [{"nameIdentifier": "8357", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohta,  K"}], "nameIdentifiers": [{"nameIdentifier": "8358", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niwa,  A"}], "nameIdentifiers": [{"nameIdentifier": "8359", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsujino,  N"}], "nameIdentifiers": [{"nameIdentifier": "8360", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakada,  T"}], "nameIdentifiers": [{"nameIdentifier": "8361", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirose,  M"}], "nameIdentifiers": [{"nameIdentifier": "8362", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "\u5c71\u7530\u5145\u5f66.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "\u5c71\u7530\u5145\u5f66.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3974/files/\u5c71\u7530\u5145\u5f66.pdf"}, "version_id": "ccdb5e1f-9953-4ca4-a1aa-0d22e66d6d54"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I-Kr and I-Ks channel suppression in guinea pig ventricular myocytes", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I-Kr and I-Ks channel suppression in guinea pig ventricular myocytes"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/1122", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2008-08-08"}, "publish_date": "2008-08-08", "publish_status": "0", "recid": "3974", "relation": {}, "relation_version_is_last": true, "title": ["Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I-Kr and I-Ks channel suppression in guinea pig ventricular myocytes"], "weko_shared_id": null}