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In guinea pig ventricular myocytes, partial block of one of the channels with complete block of the other reproducibly induced EADs. Complete block of both I-Kr and I-Ks channels depolarized the take-off potential and reduced the amplitude of EADs, which in some cases were not clearly separated from the preceding action potentials. A selective L-type Ca2+ (I-Ca,I-L) channel blocker, nifedipine, effectively suppressed EADs at submicromolar concentrations. As examined with the action potential-clamp method, I-Ca,I-L channels mediated inward currents with a spike and dome shape during action potentials. I-Ca,I-L currents decayed mainly due to inactivation in phase 2 and deactivation in phase 3 repolarization. When EADs were induced by complete block of I-Kr channels with partial block of I-Ks channels, repolarization of the action potential prior to EAD take-off failed to increase I-K1 currents and thus failed to completely deactivate I-Ca,I-L channels, which reactivated and mediated inward currents during EADs. When both I-Kr and I-Ks channels were completely blocked, I-Ca,I-L channels were not deactivated and mediated sustained inward currents until the end of EADs. Under this condition, the recovery and reactivation of I (Ca,L) channels were absent before EADs. Therefore, an essential mechanism underlying EADs caused by suppression of the delayed rectifiers is the failure to completely deactivate I-Ca,I-L channels."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamada, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8357", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohta, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8358", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niwa, A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8359", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsujino, N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8360", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakada, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8361", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirose, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8362", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "山田充彦.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "山田充彦.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3974/files/山田充彦.pdf"}, "version_id": "ccdb5e1f-9953-4ca4-a1aa-0d22e66d6d54"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I-Kr and I-Ks channel suppression in guinea pig ventricular myocytes", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I-Kr and I-Ks channel suppression in guinea pig ventricular myocytes", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/1122", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-08-08"}, "publish_date": "2008-08-08", "publish_status": "0", "recid": "3974", "relation": {}, "relation_version_is_last": true, "title": ["Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I-Kr and I-Ks channel suppression in guinea pig ventricular myocytes"], "weko_shared_id": -1}
Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I-Kr and I-Ks channel suppression in guinea pig ventricular myocytes
http://hdl.handle.net/10091/1122
http://hdl.handle.net/10091/1122a977dfec-78d0-4946-95f3-fef0786544d1
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-08-08 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I-Kr and I-Ks channel suppression in guinea pig ventricular myocytes | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Yamada, M
× Yamada, M× Ohta, K× Niwa, A× Tsujino, N× Nakada, T× Hirose, M |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Yamada, M | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jhSCupca.html | |||||
出版者 | ||||||
出版者 | SPRINGER | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JOURNAL OF MEMBRANE BIOLOGY. 222(3): 151-166(2008) | |||||
書誌情報 |
JOURNAL OF MEMBRANE BIOLOGY 巻 222, 号 3, p. 151-166, 発行日 2008-04 |
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資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0022-2631 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00702466 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s00232-008-9113-9 | |||||
関連名称 | 10.1007/s00232-008-9113-9 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
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