{"_buckets": {"deposit": "eef8efba-1618-4fe5-a880-d0cb827bd881"}, "_deposit": {"id": "3979", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3979"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003979", "sets": ["462"]}, "author_link": ["8403", "8404", "8405"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-05-16", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "1143", "bibliographicPageStart": "1139", "bibliographicVolumeNumber": "369", "bibliographic_titles": [{"bibliographic_title": "BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"}]}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット：mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 369(4): 1139-1143 (2008)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Nakajima, S", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.OhnFjeyh.html"}, {"subitem_link_text": "Taki, S", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.OhnFjeyh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000254864700029"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "ACADEMIC PRESS INC ELSEVIER SCIENCE"}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.bbrc.2008.03.004"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.bbrc.2008.03.004", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0006-291X", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0006-291X", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00564395", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "natural killer cells; interferon-gamma; type 1 interferons; pre-B cells; interleukin-7; interleukin-15; hematopoiesis"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "NATURAL-KILLER-CELLS; BONE-MARROW; DENDRITIC CELLS; INTERFERON; MICE; DIFFERENTIATION; EXPRESSION; INDUCTION; INTERLEUKIN-15; STIMULATION"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Natural killer (NK) cells are the cells critical for inhibition of repopulation of allogenic bone marrow cells. However, it is not well known if NK cells affect autologous lymphopoiesis. Here, we observed that NK cells could inhibit pre-B cell proliferation in vitro driven by interleukin (IL)-7 in a manner dependent on IL-15. Interestingly, the great majority of expanding NK cells were Mac-1(+)B220(+), a recently identified potent interferon (IFN)-7 producer. Indeed, IFN-gamma was produced in those cultures, and pre-B cells lacking IFN-gamma receptors, but not those lacking type 1 IFN receptors, were resistant to such an inhibition. Furthermore, even NK cells from mice lacking beta 2-microglobulin, which were known to be functionally dampened, inhibited pre-B cell proliferation as well. Thus, activated NK cells, which were expanded selectively by IL-15, could potentially regulate B lymphopoiesis through IFN-gamma beyond the selection imposed upon self-recognition. (C) 2008 Elsevier Inc. All rights reserved."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakajima,  S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8403", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hida,  S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8404", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Taki,  S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8405", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "IL-15 inhibits pre-B cell proliferation.pdf", "filesize": [{"value": "990.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 990900.0, "url": {"label": "IL-15 inhibits pre-B cell proliferation.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3979/files/IL-15 inhibits pre-B cell proliferation.pdf"}, "version_id": "9bfd70b2-5239-49b0-bd70-1365721dbd15"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1(+)B220(+) NK cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1(+)B220(+) NK cells", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/1090", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-06-25"}, "publish_date": "2008-06-25", "publish_status": "0", "recid": "3979", "relation": {}, "relation_version_is_last": true, "title": ["IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1(+)B220(+) NK cells"], "weko_shared_id": -1}