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We seeded embryoid bodies (EBs) originating from mouse ES cells onto mono-layered collagen membranes and cultured them in four different media. Group 1 was grown in a mixed medium of keratinocyte serum-free medium (KSFM) and Medium 199, Group 2 in a mixed medium of KSFM and conditioned medium collected from 3T3 fibroblasts, Group 3 in an EB formation medium (control group), and Group 4 in KSFM only (control group). After 28 days, cultured tissues were transplanted into nude mice. Cultured tissues from Groups 1 and 2 formed four-layered structures comprising a stratified epithelium, a submucosal loose connective tissue layer, a smooth muscle cell layer identified immunohistochemically by alpha-smooth muscle actin, and a deep loose connective tissue layer identical to the adventitia. Immunohistochemistry showed that the epithelia were positive for cytokeratins. Tissues also expressed uroplakin as detected by reverse transcription/polymerase chain reaction. In contrast, specimens from Groups 3 and 4 demonstrated necrotic features. Uroplakin-positive (i.e., urothelium-like) cells developed only in Group 2 in the transplanted culture tissues in nude mice. In addition to inducing organized layered tissues from mouse ES cells directly in vitro, these findings demonstrate that tissues cultured in KSFM plus conditioned medium from 3T3 fibroblasts differentiate into luminal walls similar to those of urinary tract in vivo. These findings suggest a new approach to urinary tract regeneration."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kinebuchi, Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8422", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Johkura, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8423", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasaki, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8424", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Imamura, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8425", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mimura, Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8426", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishizawa, O", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8427", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "杵渕 芳明.pdf", "filesize": [{"value": "269.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 269400.0, "url": {"label": "杵渕 芳明.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3983/files/杵渕 芳明.pdf"}, "version_id": "72258a40-ccc9-4300-9c7a-fbbbd38aa900"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Direct induction of layered tissues from mouse embryonic stem cells: potential for differentiation into urinary tract tissue", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Direct induction of layered tissues from mouse embryonic stem cells: potential for differentiation into urinary tract tissue", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/1058", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-05-29"}, "publish_date": "2008-05-29", "publish_status": "0", "recid": "3983", "relation": {}, "relation_version_is_last": true, "title": ["Direct induction of layered tissues from mouse embryonic stem cells: potential for differentiation into urinary tract tissue"], "weko_shared_id": -1}
Direct induction of layered tissues from mouse embryonic stem cells: potential for differentiation into urinary tract tissue
http://hdl.handle.net/10091/1058
http://hdl.handle.net/10091/10589d830450-9aef-4198-879e-490d412aed09
名前 / ファイル | ライセンス | アクション |
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杵渕 芳明.pdf (269.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-05-29 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Direct induction of layered tissues from mouse embryonic stem cells: potential for differentiation into urinary tract tissue | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s00441-007-0553-9 | |||||
関連名称 | 10.1007/s00441-007-0553-9 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Kinebuchi, Y
× Kinebuchi, Y× Johkura, K× Sasaki, K× Imamura, T× Mimura, Y× Nishizawa, O |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Johkura, K | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OeTUuUkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Nishizawa, O | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html | |||||
出版者 | ||||||
出版者 | SPRINGER | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | CELL AND TISSUE RESEARCH. 331(3): 605-615 (2008) | |||||
書誌情報 |
CELL AND TISSUE RESEARCH 巻 331, 号 3, p. 605-615, 発行日 2008-03 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The original publication is available at http://link.springer-ny.com. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0302-766X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00600105 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000253128300004 |