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Since gammaArg275His mutations have also been reported in 10 families, we synthesized recombinant gamma275His fibrinogen and gamma275Ala fibrinogen (as a control) and analyzed and compared them with gamma275Cys and gamma275Arg. Methods: A variant gamma-chain expression plasmid was transfected into Chinese hamster ovary cells expressing normal human fibrinogen Aalpha- and Bbeta-chains. After purification of the recombinant variant fibrinogens, we performed functional analyzes for thrombin-catalyzed fibrin polymerization and factor XIIIa (FXIIIa)-catalyzed gamma-gamma dimer formation from fibrin or fibrinogen and also ultrastructural analysis of fibrin clots and bundles. Results: By comparison with both gamma275His and gamma275Ala fibrinogens, recombinant gamma275Cys fibrinogen exhibited a more impaired gamma-gamma dimer formation from fibrin or fibrinogen, a more aberrant fibrin clot structure, and thicker fibers in fibrin bundles. In 1:1 mixtures of gamma275Arg and gamma275Cys fibrinogens or gamma275Arg and gamma275His fibrinogens, thrombin-catalyzed fibrin polymerization and both fibrin clot and fiber structures showed some compensation (as compared with gamma275Cys or gamma275His alone). Conclusion: These results strongly suggest that an amino acid substitution of gamma275Arg alone disrupts D:D interactions in thrombin -catalyzed fibrin polymerization and the formation of fibrin bundles and fibrin clots. Moreover, the existence of a subsequent disulfide-linked Cys in gamma275C fibrinogen augments the impairment caused by a His or Ala substitution."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hirota-Kawadobora, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8459", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Terasawa, F", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8460", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8461", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tozuka, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8462", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sano, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8463", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okumura, N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8464", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "rr275CHA-FIG.pdf", "filesize": [{"value": "2.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 2200000.0, "url": {"label": "rr275CHA-FIG.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3989/files/rr275CHA-FIG.pdf"}, "version_id": "bb5816e3-1567-4241-88d0-3e08cb99ff0e"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Comparison of thrombin-catalyzed fibrin polymerization and Factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma 275C, gamma 275H, and gamma 275A", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Comparison of thrombin-catalyzed fibrin polymerization and Factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma 275C, gamma 275H, and gamma 275A", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/1010", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-03-27"}, "publish_date": "2008-03-27", "publish_status": "0", "recid": "3989", "relation": {}, "relation_version_is_last": true, "title": ["Comparison of thrombin-catalyzed fibrin polymerization and Factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma 275C, gamma 275H, and gamma 275A"], "weko_shared_id": -1}
Comparison of thrombin-catalyzed fibrin polymerization and Factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma 275C, gamma 275H, and gamma 275A
http://hdl.handle.net/10091/1010
http://hdl.handle.net/10091/1010b4bb21a1-897b-48c3-8dc8-bb91c6690355
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-03-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Comparison of thrombin-catalyzed fibrin polymerization and Factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma 275C, gamma 275H, and gamma 275A | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Hirota-Kawadobora, M
× Hirota-Kawadobora, M× Terasawa, F× Suzuki, T× Tozuka, M× Sano, K× Okumura, N |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Suzuki, T | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HaLpuUkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Okumura, N | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OVnmgCkh.html | |||||
出版者 | ||||||
出版者 | BLACKWELL PUBL LTD | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2(8): 1359-1367 (2004) | |||||
書誌情報 |
JOURNAL OF THROMBOSIS AND HAEMOSTASIS 巻 2, 号 8, p. 1359-1367, 発行日 2004-08 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | This is an electronic version of an Article published in Journal of Thrombosis and Haemostasis 2004; 2(8): 1359-1367 | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1538-7933 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11811179 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/j.1538-7836.2004.00844.x | |||||
関連名称 | 10.1111/j.1538-7836.2004.00844.x | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000223286700025 |