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Since gammaArg275His mutations have also been reported in 10 families, we synthesized recombinant gamma275His fibrinogen and gamma275Ala fibrinogen (as a control) and analyzed and compared them with gamma275Cys and gamma275Arg. Methods: A variant gamma-chain expression plasmid was transfected into Chinese hamster ovary cells expressing normal human fibrinogen Aalpha- and Bbeta-chains. After purification of the recombinant variant fibrinogens, we performed functional analyzes for thrombin-catalyzed fibrin polymerization and factor XIIIa (FXIIIa)-catalyzed gamma-gamma dimer formation from fibrin or fibrinogen and also ultrastructural analysis of fibrin clots and bundles. Results: By comparison with both gamma275His and gamma275Ala fibrinogens, recombinant gamma275Cys fibrinogen exhibited a more impaired gamma-gamma dimer formation from fibrin or fibrinogen, a more aberrant fibrin clot structure, and thicker fibers in fibrin bundles. In 1:1 mixtures of gamma275Arg and gamma275Cys fibrinogens or gamma275Arg and gamma275His fibrinogens, thrombin-catalyzed fibrin polymerization and both fibrin clot and fiber structures showed some compensation (as compared with gamma275Cys or gamma275His alone). Conclusion: These results strongly suggest that an amino acid substitution of gamma275Arg alone disrupts D:D interactions in thrombin -catalyzed fibrin polymerization and the formation of fibrin bundles and fibrin clots. Moreover, the existence of a subsequent disulfide-linked Cys in gamma275C fibrinogen augments the impairment caused by a His or Ala substitution."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hirota-Kawadobora,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8459", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Terasawa,  F", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8460", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8461", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tozuka,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8462", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sano,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8463", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okumura,  N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8464", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "\uff52\uff52275CHA-FIG.pdf", "filesize": [{"value": "2.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 2200000.0, "url": {"label": "\uff52\uff52275CHA-FIG.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3989/files/\uff52\uff52275CHA-FIG.pdf"}, "version_id": "bb5816e3-1567-4241-88d0-3e08cb99ff0e"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Comparison of thrombin-catalyzed fibrin polymerization and Factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma 275C, gamma 275H, and gamma 275A", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Comparison of thrombin-catalyzed fibrin polymerization and Factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma 275C, gamma 275H, and gamma 275A", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/1010", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-03-27"}, "publish_date": "2008-03-27", "publish_status": "0", "recid": "3989", "relation": {}, "relation_version_is_last": true, "title": ["Comparison of thrombin-catalyzed fibrin polymerization and Factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma 275C, gamma 275H, and gamma 275A"], "weko_shared_id": -1}
  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Comparison of thrombin-catalyzed fibrin polymerization and Factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma 275C, gamma 275H, and gamma 275A

http://hdl.handle.net/10091/1010
b4bb21a1-897b-48c3-8dc8-bb91c6690355
名前 / ファイル ライセンス アクション
rr275CHA-FIG.pdf rr275CHA-FIG.pdf (2.2 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2008-03-27
タイトル
言語 en
タイトル Comparison of thrombin-catalyzed fibrin polymerization and Factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma 275C, gamma 275H, and gamma 275A
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Hirota-Kawadobora, M

× Hirota-Kawadobora, M

WEKO 8459

en Hirota-Kawadobora, M

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Terasawa, F

× Terasawa, F

WEKO 8460

en Terasawa, F

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Suzuki, T

× Suzuki, T

WEKO 8461

en Suzuki, T

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Tozuka, M

× Tozuka, M

WEKO 8462

en Tozuka, M

Search repository
Sano, K

× Sano, K

WEKO 8463

en Sano, K

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Okumura, N

× Okumura, N

WEKO 8464

en Okumura, N

Search repository
信州大学研究者総覧へのリンク
氏名 Suzuki, T
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HaLpuUkh.html
信州大学研究者総覧へのリンク
氏名 Okumura, N
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OVnmgCkh.html
出版者
出版者 BLACKWELL PUBL LTD
引用
内容記述タイプ Other
内容記述 JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2(8): 1359-1367 (2004)
書誌情報 JOURNAL OF THROMBOSIS AND HAEMOSTASIS

巻 2, 号 8, p. 1359-1367, 発行日 2004-08
内容記述
内容記述タイプ Other
内容記述 This is an electronic version of an Article published in Journal of Thrombosis and Haemostasis 2004; 2(8): 1359-1367
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1538-7933
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11811179
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/j.1538-7836.2004.00844.x
関連名称
関連名称 10.1111/j.1538-7836.2004.00844.x
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000223286700025
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