{"_buckets": {"deposit": "f7f74cce-45c5-44dd-a7ba-af5d2d76ec2f"}, "_deposit": {"id": "3995", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3995"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003995", "sets": ["462"]}, "author_link": ["8489", "8490", "8491", "8492", "8493", "8494"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2007-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "894", "bibliographicPageStart": "885", "bibliographicVolumeNumber": "21", "bibliographic_titles": [{"bibliographic_title": "Molecular endocrinology"}]}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット：mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "MOLECULAR ENDOCRINOLOGY. 21(4): 885-894 (2007)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Usami, S", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.ZmAUHUSC.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000245227100008"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "ENDOCRINE SOC"}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1210/me.2006-0403"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1210/me.2006-0403", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0888-8809", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0888-8809", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10668896", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "CYTOSOLIC 3,5,3\u0027-TRIIODO-L-THYRONINE-BINDING PROTEIN; HORMONE-BINDING PROTEIN; RAT-KIDNEY; NADPH; IDENTIFICATION; PURIFICATION; MICE; TRANSPORTERS; SPECIFICITY; EXPRESSION"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Previously, we identified reduced nicotinamide adenine dinucleotide phosphate-dependent cytosolic T-3 binding protein in rat cytosol. Cytosolic T-3-binding protein is identical to mu-crystallin (CRYM). Recently, CRYM mutations were found in patients with nonsyndromic hereditary deafness. Although it has been established that CRYM plays pivotal roles in reserving and transporting T-3 into the nuclei in vitro and has a clinical impact on hearing ability, the precise functions of CRYM remain to be elucidated in vivo. To further investigate the in vivo functions of CRYM gene products, we have generated mice with targeted disruption of the CRYM gene, which abrogates the production of CRYM. CRYM knockout loses the reduced nicotinamide adenine dinucleotide phosphate-dependent T-3 binding activity in the cytosol of the brain, kidney, heart, and liver. At the euthyroid state, knockout significantly suppresses the serum concentration of T-3 and T-4 despite normal growth, heart rate, and hearing ability. The disruption of the gene does not alter the expression of TSH beta mRNA in the pituitary gland or glutathione-S-transferase alpha 2 and deiodinase 1 mRNAs in either the liver or kidney. When radiolabeled T-3 is injected intravenously, labeled T-3 rapidly enters into and then escapes from the tissues in CRYM-knockout mice. These data suggest that because of rapid T-3 turnover, disruption of the CRYM gene decreases T-3 concentrations in tissues and serum without alteration of peripheral T-3 action in vivo."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Suzuki,  S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8489", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki,  N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8490", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mori,  J", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8491", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oshima,  A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8492", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Usami,  S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8493", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashizume,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8494", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "in_vivo_function_of_CRYM.pdf", "filesize": [{"value": "501.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 501500.0, "url": {"label": "in_vivo_function_of_CRYM.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3995/files/in_vivo_function_of_CRYM.pdf"}, "version_id": "25d83363-5a86-4104-afa7-7b492db7c999"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "mu-Crystallin as an intracellular 3,5,3 \u0027-triiodothyronine holder in vivo", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "mu-Crystallin as an intracellular 3,5,3 \u0027-triiodothyronine holder in vivo", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/979", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-02-07"}, "publish_date": "2008-02-07", "publish_status": "0", "recid": "3995", "relation": {}, "relation_version_is_last": true, "title": ["mu-Crystallin as an intracellular 3,5,3 \u0027-triiodothyronine holder in vivo"], "weko_shared_id": -1}