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Cytosolic T-3-binding protein is identical to mu-crystallin (CRYM). Recently, CRYM mutations were found in patients with nonsyndromic hereditary deafness. Although it has been established that CRYM plays pivotal roles in reserving and transporting T-3 into the nuclei in vitro and has a clinical impact on hearing ability, the precise functions of CRYM remain to be elucidated in vivo. To further investigate the in vivo functions of CRYM gene products, we have generated mice with targeted disruption of the CRYM gene, which abrogates the production of CRYM. CRYM knockout loses the reduced nicotinamide adenine dinucleotide phosphate-dependent T-3 binding activity in the cytosol of the brain, kidney, heart, and liver. At the euthyroid state, knockout significantly suppresses the serum concentration of T-3 and T-4 despite normal growth, heart rate, and hearing ability. The disruption of the gene does not alter the expression of TSH beta mRNA in the pituitary gland or glutathione-S-transferase alpha 2 and deiodinase 1 mRNAs in either the liver or kidney. When radiolabeled T-3 is injected intravenously, labeled T-3 rapidly enters into and then escapes from the tissues in CRYM-knockout mice. These data suggest that because of rapid T-3 turnover, disruption of the CRYM gene decreases T-3 concentrations in tissues and serum without alteration of peripheral T-3 action in vivo."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Suzuki, S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8489", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8490", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mori, J", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8491", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oshima, A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8492", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Usami, S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8493", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashizume, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8494", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "in_vivo_function_of_CRYM.pdf", "filesize": [{"value": "501.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 501500.0, "url": {"label": "in_vivo_function_of_CRYM.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3995/files/in_vivo_function_of_CRYM.pdf"}, "version_id": "25d83363-5a86-4104-afa7-7b492db7c999"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "mu-Crystallin as an intracellular 3,5,3 \u0027-triiodothyronine holder in vivo", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "mu-Crystallin as an intracellular 3,5,3 \u0027-triiodothyronine holder in vivo", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/979", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-02-07"}, "publish_date": "2008-02-07", "publish_status": "0", "recid": "3995", "relation": {}, "relation_version_is_last": true, "title": ["mu-Crystallin as an intracellular 3,5,3 \u0027-triiodothyronine holder in vivo"], "weko_shared_id": -1}
mu-Crystallin as an intracellular 3,5,3 '-triiodothyronine holder in vivo
http://hdl.handle.net/10091/979
http://hdl.handle.net/10091/979d40fd421-8af8-4dd0-bdad-3b2020aa3dec
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-02-07 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | mu-Crystallin as an intracellular 3,5,3 '-triiodothyronine holder in vivo | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Suzuki, S
× Suzuki, S× Suzuki, N× Mori, J× Oshima, A× Usami, S× Hashizume, K |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Usami, S | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ZmAUHUSC.html | |||||
出版者 | ||||||
出版者 | ENDOCRINE SOC | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | MOLECULAR ENDOCRINOLOGY. 21(4): 885-894 (2007) | |||||
書誌情報 |
Molecular endocrinology 巻 21, 号 4, p. 885-894, 発行日 2007-04 |
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資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0888-8809 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10668896 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1210/me.2006-0403 | |||||
関連名称 | 10.1210/me.2006-0403 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
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