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HCV core protein plays important roles in HCV-related hepatocarcinogenesis, because mice carrying the core protein exhibit multicentric HCCs without hepatic inflammation and fibrosis. However, the precise mechanism of hepatocarcinogenesis in these transgenic mice remains unclear. To evaluate whether the core protein modulates hepatocyte proliferation and apoptosis in vivo, we examined these parameters in 9- and 22-month-old transgenic mice. Although the numbers of apoptotic hepatocytes and hepatic caspase 3 activities were similar between transgenic and nontransgenic mice, the numbers of proliferating hepatocytes and the levels of numerous proteins such as cyclin D1, cyclin-dependent kinase 4 and c-Myc, were markedly increased in an age-dependent manner in the transgenic mice. This increase was correlated with the activation of peroxisome proliferator-activated receptor alpha (PPAR alpha). 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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: Implications for HCV-associated hepatocarcinogenesis

http://hdl.handle.net/10091/930
eb88dbb5-bc56-428c-83c6-813eebc3d089
名前 / ファイル ライセンス アクション
ManuscriptR200705.pdf ManuscriptR200705.pdf (309.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2008-01-21
タイトル
言語 en
タイトル Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: Implications for HCV-associated hepatocarcinogenesis
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tanaka, N

× Tanaka, N

WEKO 8508

en Tanaka, N

Search repository
Moriya, K

× Moriya, K

WEKO 8509

en Moriya, K

Search repository
Kiyosawa, K

× Kiyosawa, K

WEKO 8510

en Kiyosawa, K

Search repository
Koike, K

× Koike, K

WEKO 8511

en Koike, K

Search repository
Aoyama, T

× Aoyama, T

WEKO 8512

en Aoyama, T

Search repository
出版者
出版者 WILEY-LISS
引用
内容記述タイプ Other
内容記述 INTERNATIONAL JOURNAL OF CANCER. 122(1): 124-131
書誌情報 INTERNATIONAL JOURNAL OF CANCER

巻 122, 号 1, p. 124-131, 発行日 2008-01-01
内容記述
内容記述タイプ Other
内容記述 This is a preprint of an article published in INTERNATIONAL JOURNAL OF CANCER. Copyright (c) 2008 Wiley-Liss, Inc., A Wiley Company
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0020-7136
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00680002
他の資源との関係:URI
関連識別子
識別子タイプ URI
関連識別子 http://www3.interscience.wiley.com/cgi-bin/jhome/29331
関連名称
関連名称 http://www3.interscience.wiley.com/cgi-bin/jhome/29331
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/ijc.23056
関連名称
関連名称 10.1002/ijc.23056
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000251193700016
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