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These nodules fluctuated in parallel with myelopathy, and were diagnosed as lupus erythematosus profundus (LEP) based on histopathological findings. The patient showed no relapse of either neurological symptoms or subcutaneous nodules after cessation of (IFN)-beta-1b. This agent can cause induration and necrosis in the sites of injection but also systemic skin lesions such as LEP ascribable to its immunomodulatory effects. (c) 2006 Elsevier Ltd. All rights reserved."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Gono,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8596", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuda,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8597", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimojima,  Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8598", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kaneko,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8599", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murata,  H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8600", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikeda,  S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8601", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Lupus erythematosus profundus induced by interferon-b.pdf", "filesize": [{"value": "131.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 131200.0, "url": {"label": "Lupus erythematosus profundus induced by interferon-b.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4013/files/Lupus erythematosus profundus induced by interferon-b.pdf"}, "version_id": "d0bd0c16-45df-49f1-8837-48d903a23a8c"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Lupus erythematosus profundus (lupus panniculitis) induced by interferon-beta in a multiple sclerosis patient", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Lupus erythematosus profundus (lupus panniculitis) induced by interferon-beta in a multiple sclerosis patient", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/753", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-12-18"}, "publish_date": "2007-12-18", "publish_status": "0", "recid": "4013", "relation": {}, "relation_version_is_last": true, "title": ["Lupus erythematosus profundus (lupus panniculitis) induced by interferon-beta in a multiple sclerosis patient"], "weko_shared_id": -1}