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Before the discovery of these nuclear receptors, possible major binding sites for thyroid hormones were thought to be cytosolic owing to high thyroid hormone-binding activity in crude cytosolic fractions. Several cytosolic thyroid hormone-binding proteins have been identified, including reduced nicotinamide adenine dinucleotide phosphate (NADPH)dependent 3,5,3 \u0027-triiodo-L-thyronine (T-3)-binding protein, also known as mu-crystallin, which was initially cloned as the ortholog of bacterial ornithine cyclodeaminase. The expression of mu-crystallin is developmentally regulated and cell-type specific. Recently, patients with nonsyndromic deafness were reported to have point mutations in the R-crystallin gene. Cytosolic thyroid hormone-binding proteins, especially R-crystallin, have roles in adaptation to environmental alterations by thyroid hormone, which might have a role in hearing function."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Suzuki, S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8662", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mori, JI", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8663", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashizume, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8664", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CRYM.pdf", "filesize": [{"value": "141.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 141600.0, "url": {"label": "CRYM.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4022/files/CRYM.pdf"}, "version_id": "567672fe-64da-4cce-8ec5-81dfea5e4bb2"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "μ-crystallin, a NADPH-dependent T-3-binding protein in cytosol", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "μ-crystallin, a NADPH-dependent T-3-binding protein in cytosol", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/607", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-11-21"}, "publish_date": "2007-11-21", "publish_status": "0", "recid": "4022", "relation": {}, "relation_version_is_last": true, "title": ["μ-crystallin, a NADPH-dependent T-3-binding protein in cytosol"], "weko_shared_id": -1}
μ-crystallin, a NADPH-dependent T-3-binding protein in cytosol
http://hdl.handle.net/10091/607
http://hdl.handle.net/10091/6071e8803da-4d06-4021-8d67-10f94ccd3197
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-11-21 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | μ-crystallin, a NADPH-dependent T-3-binding protein in cytosol | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Suzuki, S
× Suzuki, S× Mori, JI× Hashizume, K |
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出版者 | ||||||
出版者 | ELSEVIER SCIENCE LONDON | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | TRENDS IN ENDOCRINOLOGY AND METABOLISM. 18(7): 286-289 | |||||
書誌情報 |
TRENDS IN ENDOCRINOLOGY AND METABOLISM 巻 18, 号 7, p. 286-289, 発行日 2007-09 |
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アドレス | ||||||
内容記述タイプ | Other | |||||
内容記述 | http://www.elsevier.com/wps/find/journaldescription.cws_home/505783/description#description | http://www.elsevier.com/wps/find/journaldescription.cws_home/505783/description#description | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1043-2760 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10746118 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.tem.2007.07.002 | |||||
関連名称 | 10.1016/j.tem.2007.07.002 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000249747000006 |