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Methods: Fifty-nine patients with COPD, 20 ex-smokers without COPD and 20 healthy subjects who had never smoked were examined for dynamic hyperinflation by metronome-paced hyperventilation with respiratory rate increasing from 20 to 30 and 40 tidal breaths/min. Dynamic hyperinflation was evaluated as the decrease in inspiratory capacity (IC) following hyperventilation, and the effects of SAAC and SABA on dynamic hyperinflation were assessed. Results: COPD patients showed a significant increase in end-expiratory lung volume and a decrease in IC following hyperventilation, and ex-smokers without COPD also showed mild but significant dynamic hyperinflation. Multiple stepwise linear regression analysis revealed that the carbon monoxide transfer coefficient (DLco/V-A) and RV/TLC were significant and independent determinants of dynamic hyperinflation in COPD. Treatment with SAAC and SABA significantly increased IC at each respiratory rate, independently of the increases in FEV1. Furthermore, SABA significantly inhibited the decrease in IC due to hyperventilation. Conclusions: These findings suggest that lung hyperinflation following hyperventilation may be a useful method for detecting dynamic hyperinflation observed not only in patients with COPD but also in ex-smokers without COPD, and both SAAC and SABA are effective in reducing dynamic hyperinflation in COPD."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Fujimoto,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8672", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshiike,  F", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8673", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yasuo,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8674", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitaguchi,  Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8675", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Urushihata,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8676", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kubo,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8677", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Honda,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8678", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "bronchodoilators.pdf", "filesize": [{"value": "234.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 234000.0, "url": {"label": "bronchodoilators.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4024/files/bronchodoilators.pdf"}, "version_id": "cd9d7c20-ffe4-4344-91aa-e210f417be42"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Effects of bronchodilators on dynamic hyperinflation following hyperventilation in patients with COPD", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Effects of bronchodilators on dynamic hyperinflation following hyperventilation in patients with COPD", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/425", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-11-08"}, "publish_date": "2007-11-08", "publish_status": "0", "recid": "4024", "relation": {}, "relation_version_is_last": true, "title": ["Effects of bronchodilators on dynamic hyperinflation following hyperventilation in patients with COPD"], "weko_shared_id": -1}
  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Effects of bronchodilators on dynamic hyperinflation following hyperventilation in patients with COPD

http://hdl.handle.net/10091/425
http://hdl.handle.net/10091/425
6d58b6e1-663a-4901-96ac-9ae04e94c3b0
名前 / ファイル ライセンス アクション
bronchodoilators.pdf bronchodoilators.pdf (234.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-11-08
タイトル
言語 en
タイトル Effects of bronchodilators on dynamic hyperinflation following hyperventilation in patients with COPD
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Fujimoto, K

× Fujimoto, K

WEKO 8672

en Fujimoto, K

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Yoshiike, F

× Yoshiike, F

WEKO 8673

en Yoshiike, F

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Yasuo, M

× Yasuo, M

WEKO 8674

en Yasuo, M

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Kitaguchi, Y

× Kitaguchi, Y

WEKO 8675

en Kitaguchi, Y

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Urushihata, K

× Urushihata, K

WEKO 8676

en Urushihata, K

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Kubo, K

× Kubo, K

WEKO 8677

en Kubo, K

Search repository
Honda, T

× Honda, T

WEKO 8678

en Honda, T

Search repository
信州大学研究者総覧へのリンク
氏名 Fujimoto, K
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.yFfaHFkh.html
信州大学研究者総覧へのリンク
氏名 Yasuo, M
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ypnegpkh.html
信州大学研究者総覧へのリンク
氏名 Urushihata, K
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakhHVkh.html
信州大学研究者総覧へのリンク
氏名 Honda, T
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WeDUHFkh.html
出版者
出版者 Blackwell Publishing
引用
内容記述タイプ Other
内容記述 Respirology. 12(1): 93-99 (2007)
書誌情報 en : Respirology

巻 12, 号 1, p. 93-99, 発行日 2007-01
内容記述
内容記述タイプ Other
内容記述 ‘The definitive version is available at www.blackwell-synergy.com '.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1323-7799
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/j.1440-1843.2006.00963.x
関連名称 10.1111/j.1440-1843.2006.00963.x
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000242907000016
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