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Three patients had no or modest hepatosplenomegaly and mild leukocytosis at presentation but subsequently showed a marked increase in spleen size with or without hematologic exacerbation, for which nonintensive chemotherapy was initiated. The other three patients with NRAS or KRAS2 glycine to serine substitution received no chemotherapy, but hematologic improvement has been observed during a 2- to 4-year follow up. In the third group, all hematopoletic cell lineages analyzed had the RAS mutations at the time of hematologic improvement, whereas DNA obtained from the nails had the wild type. Additionally, numbers of circulating granulocyte-macrophage progenitors were significantly reduced during the clinical course. 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Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations
http://hdl.handle.net/10091/273
http://hdl.handle.net/10091/2736c2b4e78-664c-41d5-b95d-6a4e376468a9
名前 / ファイル | ライセンス | アクション |
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Matsuda_juvenile_myelomonocytic_leukemias.pdf (210.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-09-07 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1182/blood-2006-09-046649 | |||||
関連名称 | 10.1182/blood-2006-09-046649 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Matsuda, K
× Matsuda, K× Shimada, A× Yoshida, N× Ogawa, A× Watanabe, A× Yajima, S× Iizuka, S× Koike, K× Yanai, F× Kawasaki, K× Yanagimachi, M× Kikuchi, A× Ohtsuka, Y× Hidaka, E× Yamauchi, K× Tanaka, M× Yanagisawa, R× Nakazawa, Y× Shiohara, M× Manabe, A× Kojima, S× Koike, K |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Nakazawa, Y | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.yCSFuNkh.html | |||||
出版者 | ||||||
出版者 | AMER SOC HEMATOLOGY | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | BLOOD. 109(12): 5477-5480 (2007) | |||||
書誌情報 |
BLOOD 巻 109, 号 12, p. 5477-5480, 発行日 2007-06-15 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | This research was originally published in Blood. Authors.Matsuda, K; Shimada, A; Yoshida, N; Ogawa, A; Watanabe, A; Yajima, S; Iizuka, S; Koike, K; Yanai, F; Kawasaki, K; Yanagimachi, M; Kikuchi, A; Ohtsuka, Y; Hidaka, E; Yamauchi, K; Tanaka, M; Yanagisawa, R; Nakazawa, Y; Shiohara, M; Manabe, A; Kojima, S; Koike, K Title. Blood. 2007;109(12):5477-5480. © by the American Society of Hematology. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0006-4971 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00567156 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000247360200065 |