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Authors.Matsuda, K; Shimada, A; Yoshida, N; Ogawa, A; Watanabe, A; Yajima, S; Iizuka, S; Koike, K; Yanai, F; Kawasaki, K; Yanagimachi, M; Kikuchi, A; Ohtsuka, Y; Hidaka, E; Yamauchi, K; Tanaka, M; Yanagisawa, R; Nakazawa, Y; Shiohara, M; Manabe, A; Kojima, S; Koike, K Title. Blood. 2007;109(12):5477-5480. \u00a9 by the American Society of Hematology.", "subitem_description_type": "Other"}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8\uff1amime\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "BLOOD. 109(12): 5477-5480 (2007)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Nakazawa, Y", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.yCSFuNkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000247360200065"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "AMER SOC HEMATOLOGY"}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1182/blood-2006-09-046649"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1182/blood-2006-09-046649", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0006-4971", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0006-4971", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00567156", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "SOMATIC PTPN11 MUTATIONS; ACUTE MYELOID-LEUKEMIA; NOONAN-SYNDROME; MYELODYSPLASTIC SYNDROMES; NEUROFIBROMATOSIS TYPE-1; CHILDHOOD; GERMLINE; CHILDREN; GENES; LEUKEMOGENESIS"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Of 11 children with juvenile myelomonocytic leukemia (JMML) carrying RAS mutations (8 with NRAS mutations, 3 with KRAS2 mutations), 5 had a profound elevation in either or both the white blood cells and spleen size at diagnosis. Three patients had no or modest hepatosplenomegaly and mild leukocytosis at presentation but subsequently showed a marked increase in spleen size with or without hematologic exacerbation, for which nonintensive chemotherapy was initiated. The other three patients with NRAS or KRAS2 glycine to serine substitution received no chemotherapy, but hematologic improvement has been observed during a 2- to 4-year follow up. In the third group, all hematopoletic cell lineages analyzed had the RAS mutations at the time of hematologic improvement, whereas DNA obtained from the nails had the wild type. Additionally, numbers of circulating granulocyte-macrophage progenitors were significantly reduced during the clinical course. Thus, some patients with JMMIL with specific RAS mutations may have spontaneously improving disease."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Matsuda,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8744", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada,  A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8745", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshida,  N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8746", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ogawa,  A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8747", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe,  A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8748", "nameIdentifierScheme": "WEKO"}]}, 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