{"_buckets": {"deposit": "cd4639eb-808c-4f28-938e-cef3860e1f96"}, "_deposit": {"id": "4038", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "4038"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00004038", "sets": ["462"]}, "author_link": ["8766", "8767", "8768", "8769", "8770", "8771", "8772", "8773", "8774"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-05-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "1048", "bibliographicPageStart": "1037", "bibliographicVolumeNumber": "57", "bibliographic_titles": [{"bibliographic_title": "Advanced Drug Delivery Reviews"}]}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット：mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Advanced Drug Delivery Reviews. 57(7): 1037-1048 (2005)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Saito, N", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html"}, {"subitem_link_text": "Takahashi, J", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.jeAhuakh.html"}, {"subitem_link_text": "Kato, H", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000229404300008"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier Science BV"}]}, "item_6_relation_46": {"attribute_name": "他の資源との関係：URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://www.elsevier.com/locate/issn/0169409X"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.elsevier.com/locate/issn/0169409X", "subitem_relation_type_select": "URI"}}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "15876402"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/15876402", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.addr.2004.12.016"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.addr.2004.12.016", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0169-409X", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0169-409X", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10689127", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "bone formation; bone repair; fracture; bone defect; recombinant human bone morphogenetic protein-2; tissue engineering"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "HUMAN OSTEOGENIC PROTEIN-1; EXPERIMENTAL SPINAL-FUSION; SEGMENTAL DEFECTS; GROWTH-FACTORS; BMP CARRIERS; STEM-CELLS; REPAIR; RHBMP-2; REGENERATION; IMPLANTS"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Bone morphogenetic proteins (BMP) induce bone formation in vivo, and clinical application in repair of bone fractures and defects is expected. However, appropriate systems to deliver BMP for clinical use need to be developed. We synthesized a new synthetic biodegradable polymer, pOly-D,L-lactic acid-para-dioxanone-polyethylene glycol block copolymer (PLA-DX-PEG), to serve as a biocompatible, biodegradable polymer for recombinant human (rh) BMP-2 delivery systems. In animal experiments, new bone was efficiently formed and a large bone defect was repaired using PLA-DX-PEG/rhBMP-2 composites. In addition, this new polymer could be used as an injectable delivery system for rhBMP-2. The rhBMP-2/PLA-DX-PEG composites also could be combined with other materials such as hydroxyapatite or titanium. This new synthetic polymer might be used for rhBMP-2 delivery in various clinical situations involving repair of bone, leading to great changes in orthopedic treatment. (c) 2005 Elsevier B.V. All rights reserved."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Saito,  N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8766", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murakami,  N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8767", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi,  J", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8768", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Horiuchi,  H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8769", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ota,  H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8770", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato,  H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8771", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okada,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8772", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nozaki,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8773", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takaoka,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8774", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Drug delivery for bone proteins.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "Drug delivery for bone proteins.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4038/files/Drug delivery for bone proteins.pdf"}, "version_id": "229f600b-a479-4f3c-b231-4dd1504e32c9"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/238", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-06-06"}, "publish_date": "2007-06-06", "publish_status": "0", "recid": "4038", "relation": {}, "relation_version_is_last": true, "title": ["Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins"], "weko_shared_id": -1}